Abstract: A circuit includes an error amplifier including a reference input, a feedback input, and an error output. A compensation network has a frequency input and a compensation output, in which the compensation output is coupled to the error output. The compensation network configured to provide a variable capacitance between the compensation output and a ground terminal based on a frequency signal at the frequency input having a value representative of a frequency of a clock signal.

Abstract: A method for measuring a temperature and/or a strain in an optical fiber includes calibrating the optical fiber by measuring a signal sensitive to an intensity and a phase of a Rayleigh backscattering signal of the optical fiber at a known state of temperature and a known state of strain, for various conditions of frequencies or wavelengths or wavenumbers of the backscattered signal and/or of known states of temperature and/or known states of strain, and for at least one longitudinal position inside the fiber.

Abstract: A dendrimer including a ring core moiety, a paramagnetic group, a linking moiety and a branching moiety for continuously probing and quantifying an analyte is provided together with methods, kits and devices for performing sensitive, accurate and durable measurements.

Abstract: A converter control circuit includes a terminal to be coupled to a switch node. The control circuit includes a valley sensing circuit coupled to the terminal and detects valleys in an oscillating voltage on the switch node. The valley sensing circuit has a first output and asserts a first control signal on the first output indicative of occurrence of a valley. A logic gate has a second output and asserts a second control signal on the second output to turn on a switching transistor. A switch-on control circuit has a first input and a second input. The first input couples to the first output. The second input couples to the second output. The switch-on control circuit asserts a third control signal to turn on the switching transistor responsive to the second control signal indicating that the switching transistor is to be on while the first control indicates a valley.

Abstract: A converter control circuit includes a terminal to be coupled to a switch node. The control circuit includes a valley sensing circuit coupled to the terminal and detects valleys in an oscillating voltage on the switch node. The valley sensing circuit has a first output and asserts a first control signal on the first output indicative of occurrence of a valley. A logic gate has a second output and asserts a second control signal on the second output to turn on a switching transistor. A switch-on control circuit has a first input and a second input. The first input couples to the first output. The second input couples to the second output. The switch-on control circuit asserts a third control signal to turn on the switching transistor responsive to the second control signal indicating that the switching transistor is to be on while the first control indicates a valley.

Abstract: A dendrimer including a ring core moiety, a paramagnetic group, a linking moiety and a branching moiety for continuously probing and quantifying an analyte is provided together with methods, kits and devices for performing sensitive, accurate and durable measurements.

Abstract: A volumetric radiation dose detector provides radiation sensors distributed along a closed surface presenting surface normals that vary over a range of azimuth and altitude angles to provide accurate dose modeling for radiation received at a comparable range of angles. Concentric layers of surfaces provide volumetric dose information that can be used to directly produce useful dose maps and assessments.

Abstract: A volumetric radiation dose detector provides radiation sensors distributed along a closed surface presenting surface normals that vary over a range of azimuth and altitude angles to provide accurate dose modeling for radiation received at a comparable range of angles. Concentric layers of surfaces provide volumetric dose information that can be used to directly produce useful dose maps and assessments.

Abstract: In operation of a flybuck converter, a first output capacitor is charged and, after this charging, charge is transferred from the first output capacitor to a second output capacitor. The charge transferring includes closing a switch to establish a first current path through which the first output capacitor discharges current that induces, in a second current path, current that charges the second output capacitor. While the switch is closed during the charge transfer, a current limit condition in the switch is detected. In response to detection of the current limit condition, the switch is opened, and is thereafter closed again before attempting to charge the first output capacitor again, thereby to resume transferring charge from the first output capacitor to the second output capacitor.

Abstract: In operation of a flybuck converter, a first output capacitor is charged and, after this charging, charge is transferred from the first output capacitor to a second output capacitor. The charge transferring includes closing a switch to establish a first current path through which the first output capacitor discharges current that induces, in a second current path, current that charges the second output capacitor. While the switch is closed during the charge transfer, a current limit condition in the switch is detected. In response to detection of the current limit condition, the switch is opened, and is thereafter closed again before attempting to charge the first output capacitor again, thereby to resume transferring charge from the first output capacitor to the second output capacitor.

Abstract: A technique for determining conditions downhole in a well, particularly load conditions acting on a well tool, e.g. a bottom hole assembly. The loads acting on a bottom hole assembly or other well tool during a well related operation are measured. Load data is collected and may be transmitted uphole in real time for evaluation at a surface control unit. Based on the load data and other possible data related to the downhole operation, corrective actions can be taken to improve the operation.

Abstract: A technique for determining conditions downhole in a well, particularly load conditions acting on a well tool, e.g. a bottom hole assembly. The loads acting on a bottom hole assembly or other well tool during a well related operation are measured. Load data is collected and may be transmitted uphole in real time for evaluation at a surface control unit. Based on the load data and other possible data related to the downhole operation, corrective actions can be taken to improve the operation.

Abstract: A fiber optic based logging assembly deliverable via coiled tubing. The downhole portion of the assembly is directed to develop a logging profile of a well by way of the fiber optic line. Thus, a downhole battery may be provided with the tool. Further, opto-electric interfaces may be provided with the assembly to convert between electrical and optical communication signals. Additionally, with the reduced profile of an optical communication line through the coiled tubing portion of the assembly, an operator may elect to perform treatment applications in real-time. That is, in certain circumstances, the operator may direct a treatment application utilizing the downhole assembly in response to the developing well profile (i.e. without first requiring that the assembly be withdrawn and replaced with a solely dedicated treatment assembly).

Abstract: An anti-HIV vaccine composition is disclosed. The vaccine comprises an combination of immunogenic peptide mixtures, which mixtures may be prepared in a single synthesis. The composition collectively represents the in vivo variability seen in immunogenic epitopes from highly variable regions of HIV. Immunization with the vaccine elicits broadly reactive immunity (CTL and T helper cell responses) against the divergent strains of HIV upon which it is based. The vaccine may be formulated to target regionally distinct variability based on an HIV clade predominant in a geographical region.

Abstract: A process is disclosed for preparation of a immunogenic peptide mixture in a single synthesis. The peptide mixture collectively represents the in vivo variability seen in immunogenic epitopes from an HIV pathogen. The mixture is termed a hypervariable epitope construct (HEC). Immunization with a HEC evokes broadly reactive immunity against divergent strains of a pathogen upon which the HEC is based.

Abstract: A fiber optic based logging assembly deliverable via coiled tubing. The downhole portion of the assembly is directed to develop a logging profile of a well by way of the fiber optic line. Thus, a downhole battery may be provided with the tool. Further, opto-electric interfaces may be provided with the assembly to convert between electrical and optical communication signals. Additionally, with the reduced profile of an optical communication line through the coiled tubing portion of the assembly, an operator may elect to perform treatment applications in real-time. That is, in certain circumstances, the operator may direct a treatment application utilizing the downhole assembly in response to the developing well profile (i.e. without first requiring that the assembly be withdrawn and replaced with a solely dedicated treatment assembly).

Abstract: An anti-HIV vaccine composition is disclosed. The vaccine comprises an combination of immunogenic peptide mixtures, which mixtures may be prepared in a single synthesis. The composition collectively represents the in vivo variability seen in immunogenic epitopes from highly variable regions of HIV. Immunization with the vaccine elicits broadly reactive immunity (CTL and T helper cell responses) against the divergent strains of HIV upon which it is based. The vaccine may be formulated to target regionally distinct variability based on an HIV clade predominant in a geographical region.

Abstract: Peptide-based anti-influenza formulations against influenza A and B are disclosed. The peptides are derived from influenza-based epitopes. The formulations are based on peptide mixtures which may be formulated so that variability is present at particular residues. The formulations can be used to prepare vaccines for preventing influenza in human, avian, murine or equine animals.

Abstract: A technique for determining conditions downhole in a well, particularly load conditions acting on a well tool, e.g. a bottom hole assembly. The loads acting on a bottom hole assembly or other well tool during a well related operation are measured. Load data is collected and may be transmitted uphole in real time for evaluation at a surface control unit. Based on the load data and other possible data related to the downhole operation, corrective actions can be taken to improve the operation.

Abstract: A process is disclosed for preparation of a immunogenic peptide mixture in a single synthesis. The peptide mixture collectively represents the in vivo variability seen in immunogenic epitopes from a pathogen. The mixture is termed a hypervariable epitope construct (HEC). Immunization with a HEC evokes broadly reactive immunity against divergent strains of a pathogen upon which the HEC is based.