Patents by Inventor Jose William Saldanha

Jose William Saldanha has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FAP&agr;-specific antibody with improved producibility
    Patent number: 6455677
    Abstract: Recombinant antibody proteins are provided that specifically bind fibroblast activation protein alpha (FAP&agr;) and comprise framework modifications resulting in the improved producibility in host cells. The invention also relates to the use of said antibodies for diagnostic and therapeutic purposes and methods of producing said antibodies.
    Type: Grant
    Filed: April 29, 1999
    Date of Patent: September 24, 2002
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: John Edward Park, Pilar Garin-Chesa, Uwe Bamberger, Wolfgang J. Rettig, Olivier Lèger, Jose William Saldanha
  • FAPALPHA-SPECIFIC ANTIBODY WITH IMPROVED PRODUCIBILITY
    Publication number: 20020052480
    Abstract: Recombinant antibody proteins are provided that specifically bind fibroblast activation protein alpha (FAP&agr;) and comprise framework modifications resulting in the improved producibility in host cells. The invention also relates to the use of said antibodies for diagnostic and therapeutic purposes and methods of producing said antibodies.
    Type: Application
    Filed: April 29, 1999
    Publication date: May 2, 2002
    Inventors: JOHN EDWARD PARK, PILAR GARIN-CHESA, UWE BAMBERGER, WOLFGANG J. RETTIG, OLIVIER LEGER, JOSE WILLIAM SALDANHA
  • Reshaped human antibody to human interleukin-6 receptor
    Patent number: 5817790
    Abstract: A reshaped human antibody to the human IL-6R, comprising:(A) an L chain comprising,(1) a human L chain C region, and(2) an L chain V region comprising human L chain framework regions (FRs), and mouse L chain complementary determination regions (CDRs) of a monoclonal antibody to the IL-6 receptor (IL-6R); and(B) an H chain comprising,(1) a human H chain C region, and(2) an H chain V region comprising human H chain FRs, and mouse H chain CDRs of a monoclonal antibody to the IL-6R.Since major portion of the reshaped human antibody is derived from a human antibody and the mouse CDRs which are less immunogenic, the present reshaped human antibody is less immunogenic to human, and therefor is promised for therapeutic uses.
    Type: Grant
    Filed: May 8, 1995
    Date of Patent: October 6, 1998
    Assignee: Chugai Seiyaku Kabushiki
    Inventors: Masayuki Tsuchiya, Koh Sato, Mary Margaret Bendig, Steven Tarran Jones, Jose William Saldanha
  • Reshaped human to human interleukin-6 receptor
    Patent number: 5795965
    Abstract: A reshaped human antibody to the human IL-6R, comprising:(A) an L chain comprising,(1) a human L chain C region, and(2) an L chain V region comprising human L chain framework regions (FRs), and mouse L chain complementary determination regions (CDRS) of a momoclonal antibody to the IL-6 receptor (IL-6R); and(B) an H chain comprising,(1) a human H chain C region, and(2) an H chain V region comprising human H chain FRs, and mouse H chain CDRs of a monoclonal antibody to the IL-6R.Since major portion of the reshaped human antibody is derived from a human antibody and the mouse CDRs which are less immunogenic, the present reshaped human antibody is less immunogenic to human, and therefor is promised for therapeutic uses.
    Type: Grant
    Filed: December 20, 1993
    Date of Patent: August 18, 1998
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Masayuki Tsuchiya, Koh Sato, Mary Margaret Bendig, Steven Tarran Jones, Jose William Saldanha