Patents by Inventor Josee Laliberte

Josee Laliberte has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cytidine deaminase cDNA as a positive selectable marker for gene transfer, gene therapy and protein synthesis
    Patent number: 6083719
    Abstract: The present invention relates to a DNA sequence for the human cytidine deaminase that has been engineered into an eukaryotic expression vector, thereby permitting cytidine deaminase expression in mammalian cells. Cytidine deaminase expression confers resistance to cytosine nucleoside analogs, such as cytosine arabinoside, and can be used as a positive selectable marker. The expression of cytidine deaminase in cells protects them from the toxic effects of cytosine nucleoside analogs. Such a resistance provides applications for gene therapy of malignant, immune and viral diseases. A bacterial expression vector containing the gene can be used to produce cytidine deaminase in large quantities.
    Type: Grant
    Filed: October 27, 1997
    Date of Patent: July 4, 2000
    Assignee: Hopital Sainte-Justine
    Inventors: Richard L. Momparler, Josee Laliberte, Denis Cournoyer, Nicoletta Eliopoulos