Patents by Inventor Josee Roy

Josee Roy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10098970
    Abstract: The invention provides methods and composition developed to be used with imaging techniques and useful for diagnosis and monitoring the pain generator(s) of axial pain with or without radiculopathy and methods for screening therapeutic compounds potentially useful for treating axial pain with or without radiculopathy. Alternatively, degenerated discs can be monitored and treated before occurrence of a pathological pain condition. Pain markers and markers of degeneration include markers of neuronal, vascular, immune and matrix elements.
    Type: Grant
    Filed: April 11, 2017
    Date of Patent: October 16, 2018
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: William F. McKay, Jeffrey M. Gross, Hai Trieu, Josee Roy, Susan J. Drapeau, Michael J. Schendel, Andrew J. Lowenthal Walsh
  • Patent number: 9968572
    Abstract: Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of clonidine and a gamma-aminobutyric acid compound at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: May 15, 2018
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Jared T. Wilsey, Danielle L. Clay, Jeffrey C. Marx, William F. McKay, Josee Roy, John Myers Zanella
  • Patent number: 9950005
    Abstract: The invention provides compositions, kits, and methods for treatment of neuronal injury. In one embodiment, the composition comprises a biomembrane sealing agent, such as PEG, and a bioactive agent, such as a magnesium compound. The biomembrane sealing agent and/or the bioactive agent an intravenous administration, an intramuscular administration, an intrathecal administration, a subcutaneous administration, an epidural administration, a parenteral administration, a direct application onto or adjacent to a site of the pathological condition, and any combinations thereof. Alternatively, the biomembrane sealing agent and/or the bioactive agent may be delivered from a pump or an implant.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: April 24, 2018
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Josee Roy, William F. McKay, Jeffrey C. Marx
  • Publication number: 20180021406
    Abstract: The invention provides a method for alleviating discogenic pain by administering a therapeutic agent that disrupts neuronal and/or vascular elements in the disc, which is typically a degenerated disc. Disruption of neuronal elements in the disk includes destroying nerve endings without substantially affecting the central body of the nerve, suppressing activation of the nerve endings, and inhibiting the growth of nerve endings into the disk. Disruption of vascular elements includes causing the vascular extensions to retract from the disk, or suppressing the formation of such extensions. The therapeutic agent may be administered locally via an interbody pump, a bolus or a depot, or may be administered systemically.
    Type: Application
    Filed: September 29, 2017
    Publication date: January 25, 2018
    Inventors: Josee Roy, Susan J. Drapeau, Jeffrey C. Marx
  • Patent number: 9789161
    Abstract: The invention provides a method for alleviating discogenic pain by administering a therapeutic agent that disrupts neuronal and/or vascular elements in the disc, which is typically a degenerated disc. Disruption of neuronal elements in the disk includes destroying nerve endings without substantially affecting the central body of the nerve, suppressing activation of the nerve endings, and inhibiting the growth of nerve endings into the disk. Disruption of vascular elements includes causing the vascular extensions to retract from the disk, or suppressing the formation of such extensions. The therapeutic agent may be administered locally via an interbody pump, a bolus or a depot, or may be administered systemically.
    Type: Grant
    Filed: April 28, 2006
    Date of Patent: October 17, 2017
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Josee Roy, Susan J. Drapeau, Jeffrey C. Marx
  • Patent number: 9757476
    Abstract: The invention provides methods and composition developed to be used with imaging techniques and useful for diagnosis and monitoring the pain generator(s) of axial pain with or without radiculopathy and methods for screening therapeutic compounds potentially useful for treating axial pain with or without radiculopathy. Alternatively, degenerated discs can be monitored and treated before occurrence of a pathological pain condition. Pain markers and markers of degeneration include markers of neuronal, vascular, immune and matrix elements.
    Type: Grant
    Filed: June 8, 2006
    Date of Patent: September 12, 2017
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: William F. McKay, Jeffrey M. Gross, Hai Trieu, Josee Roy, Susan J. Drapeau, Michael J. Schendel, Andrew J. Lowenthal Walsh
  • Patent number: 9737071
    Abstract: Disclosed are compositions and methods for the preservation, storage, and transport of living biological tissues, organs, and populations of isolated cells. In particular, the disclosed compositions and processes permit mammalian cells, tissues, and organs to be harvested from suitable donor animals, stored for prolonged periods, and transported to the site of recipient implantation, all without significant loss of cell viability, biological activity, and/or tissue integrity.
    Type: Grant
    Filed: December 24, 2014
    Date of Patent: August 22, 2017
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Daniel Andrew Shimko, Scott P. Noel, Susan J. Drapeau, Josee Roy
  • Patent number: 9730986
    Abstract: The invention provides a method for alleviating discogenic pain by administering a therapeutic agent that disrupts neuronal and/or vascular elements in the disc, which is typically a degenerated disc. Disruption of neuronal elements in the disk includes destroying nerve endings without substantially affecting the central body of the nerve, suppressing activation of the nerve endings, and inhibiting the growth of nerve endings into the disk. Disruption of vascular elements includes causing the vascular extensions to retract from the disk, or suppressing the formation of such extensions. The therapeutic agent may be administered locally via an interbody pump, a bolus or a depot, or may be administered systemically.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: August 15, 2017
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Josee Roy, Susan J. Drapeau, Jeffrey C. Marx
  • Publication number: 20170216459
    Abstract: The invention provides methods and composition developed to be used with imaging techniques and useful for diagnosis and monitoring the pain generator(s) of axial pain with or without radiculopathy and methods for screening therapeutic compounds potentially useful for treating axial pain with or without radiculopathy. Alternatively, degenerated discs can be monitored and treated before occurrence of a pathological pain condition. Pain markers and markers of degeneration include markers of neuronal, vascular, immune and matrix elements.
    Type: Application
    Filed: April 11, 2017
    Publication date: August 3, 2017
    Inventors: William F. McKay, Jeffrey M. Gross, Hai Trieu, Josee Roy, Susan J. Drapeau, Michael J Schendel, Andrew J. Lowenthal Walsh
  • Patent number: 9717756
    Abstract: The invention provides methods and kits for treatment of pain or inflammation. In one embodiment, the kit comprises a biomembrane sealing agent, such as PEG, and a bioactive agent, such as a magnesium compound. The biomembrane sealing agent and/or the bioactive agent an intravenous administration, an intramuscular administration, an intrathecal administration, a subcutaneous administration, an epidural administration, a parenteral administration, an intra-articular administration, a direct application onto or adjacent to a site of the pathological condition, and any combinations thereof. Alternatively, the biomembrane sealing agent and/or the bioactive agent may be delivered from a pump or an implant.
    Type: Grant
    Filed: September 22, 2014
    Date of Patent: August 1, 2017
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Josee Roy, William F. McKay, Jeffrey C. Marx
  • Patent number: 9610243
    Abstract: Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of clonidine in a drug depot at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain. When appropriate drug depot formulations are provided within biodegradable polymers, this pain relief can be continued for at least fourteen days.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: April 4, 2017
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Danielle L. Clay, Josee Roy, William F. McKay
  • Patent number: 9597352
    Abstract: In the present invention, Applicants demonstrate the effect of a biomembrane sealing agent on the development of chronic pain following tissue injury as well as acute pain in a model of acute inflammation. Applicants demonstrate the ability of this class of agents referred to as “biomembrane sealing agents” to reduce the severity of hyperalgesia and allodynia following mechanical insult to the nervous system as well as their ability to reduce acute pain in a model of acute inflammation. Applicant describes the use of injectable or depot formulations of biomembrane sealing agent(s) for prophylactic treatment such as they could be administered after the insult (i.e. post-injury or post-surgery) but before the onset of acute or chronic pain. Alternatively, biomembrane sealing agents could be used to reduce the severity of acute or chronic pain after onset.
    Type: Grant
    Filed: May 31, 2006
    Date of Patent: March 21, 2017
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Josee Roy, Jeffrey C. Marx
  • Patent number: 9486478
    Abstract: Compositions are provided for preferential distribution of active agents to injury sites. Such compositions may comprise a ligand with hydrophilic properties and one or more active agents, such as compounds comprising hydrophilic metal ions. Because the delivery ligand and the active agent are specifically selected so the interactions between them are mainly of an ionic nature so that binding of the active agent to the delivery ligand and release of the active agent into the target site are not dependent on enzymatic activity. Methods of using such compositions are also disclosed.
    Type: Grant
    Filed: October 3, 2014
    Date of Patent: November 8, 2016
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Josee Roy, Toya Kimble
  • Publication number: 20160296647
    Abstract: Methods are provided that better describe, and localize the pain generator or suspected pain generator in and around spinal discs in relation to neck or back pain so as to improve the diagnosis of degenerative disc disease. In some embodiments, there are methods for diagnosing a pain generator or a suspected pain generator in a patient suffering from back pain, the methods comprise labeling an inflammatory, vascular, neuronal, and/or metabolic pain marker at a location inside of or adjacent to an intervertebral disc in the patient suffering from back pain to increase an image of the pain marker with an imaging procedure; and imaging the labeled inflammatory, vascular, neuronal, and/or metabolic pain marker in a manner sufficient to diagnose the pain generator or suspected pain generator.
    Type: Application
    Filed: June 13, 2016
    Publication date: October 13, 2016
    Inventor: Josee Roy
  • Patent number: 9452183
    Abstract: Methods of treating hemorrhage are provided, comprising diagnosing one or more hemorrhaging or potentially hemorrhaging vessels in a patient and administering to the patient a therapeutically effective amount of a composition comprising a vessel closing compound at a concentration between about 0.1% and about 45%. The vessel closing compound may comprise a polymer with hydrophilic properties, such as polyethylene glycol (PEG). The composition may also comprise one or more active agent such as a blood flow modifier with a potential to form ionic bonds with the vessel closing agent.
    Type: Grant
    Filed: October 10, 2014
    Date of Patent: September 27, 2016
    Assignee: Warsaw Orthopedic, Inc.
    Inventor: Josee Roy
  • Publication number: 20160213630
    Abstract: Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of clonidine and a gamma-aminobutyric acid compound at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.
    Type: Application
    Filed: March 31, 2016
    Publication date: July 28, 2016
    Inventors: Jared T. Wilsey, Danielle L. Clay, Jeffrey C. Marx, William F. McKay, Josee Roy, John Myers Zanella
  • Patent number: 9364568
    Abstract: Methods are provided that better describe, and localize the pain generator or suspected pain generator in and around spinal discs in relation to neck or back pain so as to improve the diagnosis of degenerative disc disease. In some embodiments, there are methods for diagnosing a pain generator or a suspected pain generator in a patient suffering from back pain, the methods comprise labeling an inflammatory, vascular, neuronal, and/or metabolic pain marker at a location inside of or adjacent to an intervertebral disc in the patient suffering from back pain to increase an image of the pain marker with an imaging procedure; and imaging the labeled inflammatory, vascular, neuronal, and/or metabolic pain marker in a manner sufficient to diagnose the pain generator or suspected pain generator.
    Type: Grant
    Filed: July 15, 2010
    Date of Patent: June 14, 2016
    Assignee: Warsaw Orthopedic, Inc.
    Inventor: Josee Roy
  • Patent number: 9301946
    Abstract: Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of clonidine and a gamma-aminobutyric acid compound at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.
    Type: Grant
    Filed: December 2, 2011
    Date of Patent: April 5, 2016
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Jared T. Wilsey, Danielle L. Biggs, Jeffrey C. Marx, William F. McKay, Josee Roy, John Myers Zanella
  • Patent number: 9244060
    Abstract: Methods for identifying defects in blood vessels and treating such defects are provided. The methods comprise administering to a patient a composition comprising a labeled delivery ligand capable of preferentially accumulating at or near blood vessels defects. In some embodiments, the delivery ligand may carry one or more active agents to the defect.
    Type: Grant
    Filed: March 26, 2009
    Date of Patent: January 26, 2016
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Josee Roy, Roger Harrington
  • Publication number: 20150342964
    Abstract: A biodegradable drug implant for reducing, preventing or treating pain and/or inflammation in a patient is provided. The biodegradable drug implant comprises dexamethasone and a polylactic acid polyglycolic acid (PLGA) copolymer matrix, wherein the dexamethasone comprises from about 50% to about 80% by weight of the drug implant. Methods of treating pain in a patient are also provided.
    Type: Application
    Filed: May 30, 2014
    Publication date: December 3, 2015
    Applicant: Warsaw Orthopedic, Inc.
    Inventors: Jonathan Gray, Jeffrey C. Marx, William F. McKay, Josee Roy, Jared T. Wilsey