Patents by Inventor Josef A. Rechka

Josef A. Rechka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PREPARATION OF C-PYRAZINE-METHYLAMINES
    Publication number: 20130261306
    Abstract: A process for preparing a compound of formula (I) or a salt thereof: (I) wherein R1 is H or optionally substituted aryl or heteroaryl; comprising reacting 2,3-dichloropyrazine with a suitable diaryl imine followed by hydrolysis.
    Type: Application
    Filed: May 23, 2013
    Publication date: October 3, 2013
    Applicant: OSI Pharmaceuticals, LLC
    Inventors: Yunyu Mao, Kristen Michelle Mulvihill, Josef A. Rechka, Paula A. Tavares-Greco
  • Preparation of -pyrazine-methylamines
    Patent number: 8513415
    Abstract: A process for preparing a compound of formula (I) or a salt thereof: (I) wherein R1 is H or optionally substituted aryl or heteroaryl; comprising reacting 2,3-dichloropyrazine with a suitable diaryl imine followed by hydrolysis.
    Type: Grant
    Filed: April 19, 2010
    Date of Patent: August 20, 2013
    Assignee: OSI Pharmaceuticals, LLC
    Inventors: Yunyu Mao, Josef A. Rechka, Paula A. Tavares-Greco
  • Polymorphs of OSI-906
    Publication number: 20130158264
    Abstract: Polymorphic forms of the tyrosine kinase inhibitor OSI-906, preparation, pharmaceutical compositions, and uses thereof. The invention includes methods of treating diseases such as cancer, including cancer mediated at least in part by IGF-1 R and/or IR, with the polymorphs and compositions. This Abstract is not limiting of the invention.
    Type: Application
    Filed: June 23, 2011
    Publication date: June 20, 2013
    Inventors: Arlindo L. Castelhano, David A. Enger, Jason A. Hanko, Josef A. Rechka, Jing Teng, Yonglai Yang
  • PROCESS FOR THE PREPARATION OF THE COMPOUND OSI-906
    Publication number: 20130123501
    Abstract: Process for preparing the tyrosine kinase inhibitor OSI-906 comprises coupling Compound (2) with Compound (6) under specified conditions.
    Type: Application
    Filed: July 29, 2011
    Publication date: May 16, 2013
    Inventors: Arlindo L. Castelhano, Gary A. Cutting, Andrew J. Locke, Kristen Michelle Mulvihill, Robert Norrie, Andrew J. O'brien, Stuart R. Park, Josef A. Rechka, Andrew MIchael Stevens, Christopher I. Thomas
  • PROCESS FOR SUBSTITUTED 3-AMINO-5-OXO-4,5-DIHYDRO-[1,2,4]TRIAZINES
    Publication number: 20120108812
    Abstract: Processes including preparation of trans-4-[(3-amino-5-oxo-4,5-dihydro-[1,2,4]triazin-6-ylmethyl)-carbamoyl]-cyclohexanecarboxylic acid methyl ester, and its conversion to trans-4-(4-amino-5-substituted-imidazo[5,1-f][1,2,4]triazin-7-yl)-cyclohexanecarboxylic acid compounds.
    Type: Application
    Filed: July 8, 2010
    Publication date: May 3, 2012
    Inventors: Hanqing Dong, Yunyu Mao, Kristen Michelle Mulvhill, Josef A. Rechka, Douglas S. Werner
  • Preparation of C-Pyrazine-Methylamines
    Publication number: 20120041202
    Abstract: A process for preparing a compound of formula (I) or a salt thereof: (I) wherein R1 is H or optionally substituted aryl or heteroaryl; comprising reacting 2,3-dichloropyrazine with a suitable diaryl imine followed by hydrolysis.
    Type: Application
    Filed: April 19, 2010
    Publication date: February 16, 2012
    Inventors: Yunyu Mao, Kristen Michelle Mulvihill, Josef A. Rechka, Paula A. Tavares-Greco
  • mTOR INHIBITOR SALT FORMS
    Publication number: 20110015197
    Abstract: Salt forms of mTOR inhibitors of the Formula (I): and methods of preparation, formulation, and use in treating disease.
    Type: Application
    Filed: March 18, 2009
    Publication date: January 20, 2011
    Applicant: OSI Pharmaceuticals, Inc.
    Inventors: Arlindo L. Castelhano, Kristen Michelle Mulvihill, Josef A. Rechka, Gary C. Visor
  • Process for the preparation of citalopram
    Patent number: 7002025
    Abstract: Preparation of citalopram comprises the steps of: (a) converting the compound of Formula (I) to a compound of Formula (II), wherein R in Formula (I) represents a C2 to C5 alkylene group which may be substituted or unsubstituted, and R1 in the compounds of Formula (II) represents a carboxylic acid group or a salt or an ester thereof; and (b) converting the compound of Formula (II) to form citalopram or a pharmaceutically acceptable salt thereof, or a direct conversion of the compound of Formula (I) to citalopram
    Type: Grant
    Filed: March 7, 2001
    Date of Patent: February 21, 2006
    Assignee: Resolution Chemicals Limited
    Inventors: Alan K. Greenwood, Derek McHattie, Josef A. Rechka, Paul C. M. Hedger, Mark P. Gamble
  • Process for the preparation of citalopram
    Publication number: 20040014997
    Abstract: Preparation of citalopram comprises the steps of: (a) converting the compound of Formula (I) to a compound of Formula (II), wherein R in Formula (I) represents a C2 to C5 alkylene group which may be substituted or unsubstituted, and R1 in the compounds of Formula (II) represents a carboxylic acid group or a salt or an ester thereof; and (b) converting the compound of Formula (II) to form citalopram or a pharmaceutically acceptable salt thereof, or a direct conversion of the compound of Formula (I) to citalopram 1
    Type: Application
    Filed: December 16, 2002
    Publication date: January 22, 2004
    Inventors: Alan Kenneth Greenwood, Derek McHattie, Josef A. Rechka, Paul C.M. Hedger, Mark P. Gamble