Patents by Inventor Josef Coresh

Josef Coresh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200292558
    Abstract: Described herein are methods for identification/discovery of protein biomarkers for chronic kidney disease (CKD) and diagnosing and/or prognosing and/or predicting progression of and/or treating chronic kidney disease (CKD).
    Type: Application
    Filed: October 12, 2018
    Publication date: September 17, 2020
    Applicants: Cedars-Sinai Medical Center, THE JOHNS HOPKINS UNIVERSITY
    Inventors: Jennifer VAN EYK, Qin FU, Vidya VENKATRAMAN, Zongming FU, Josef CORESH
  • Publication number: 20170276669
    Abstract: The present invention relates to the field of nephrology. More specifically, the present invention provides methods and compositions useful for more precisely estimating glomerular filtration rate (GFR). In a specific embodiment, a method for calculating the estimated glomerular filtration rate (eGFR) in a patient comprises the steps of (a) measuring the level of one or more metabolites using mass spectrometry from a blood sample obtained from the patient; and (b) calculating the eGFR using an algorithm that utilizes the measured levels of the one or more metabolites.
    Type: Application
    Filed: August 11, 2015
    Publication date: September 28, 2017
    Inventors: Josef CORESH, Andrew LEVEY, Lesley INKER
  • Patent number: 8722338
    Abstract: Genome-wide association studies (GWAS) was recently used to identify SNPs in a genomic region on chromosome 4 that associate with serum urate levels and gout. The present disclosure shows that human ATP-binding cassette, subfamily G, 2 (ABCG2), encoded by the ABCG2 gene contained in this region, is a hitherto unknown urate efflux transporter. The present disclosure further shows that native ABCG2 is located in the brush border membrane of kidney proximal tubule cells, where it mediates renal urate secretion. Introduction of the mutation Q141K encoded by the common SNP rs2231142 by site-directed mutagenesis resulted in reduced urate transport rates compared to wild-type ABCG2. Data from a population-based study of 14,783 individuals support rs2231142 as the causal variant in the region and show highly significant associations with urate levels and gout.
    Type: Grant
    Filed: March 11, 2010
    Date of Patent: May 13, 2014
    Assignee: The Johns Hopkins University
    Inventors: Michael Kottgen, Josef Coresh, William Guggino, Anna Kottgen, Owen Woodward
  • Publication number: 20120010102
    Abstract: Genome-wide association studies (GWAS) was recently used to identify SNPs in a genomic region on chromosome 4 that associate with serum urate levels and gout. The present disclosure shows that human ATP-binding cassette, subfamily G, 2 (ABCG2), encoded by the ABCG2 gene contained in this region, is a hitherto unknown urate efflux transporter. The present disclosure further shows that native ABCG2 is located in the brush border membrane of kidney proximal tubule cells, where it mediates renal urate secretion. Introduction of the mutation Q141K encoded by the common SNP rs2231142 by site-directed mutagenesis resulted in reduced urate transport rates compared to wild-type ABCG2. Data from a population-based study of 14,783 individuals support rs2231142 as the causal variant in the region and show highly significant associations with urate levels and gout.
    Type: Application
    Filed: March 11, 2010
    Publication date: January 12, 2012
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Michael Kottgen, Josef Coresh, William Guggino, Anna Kottgen, Owen Woodward