Patents by Inventor Josef Fried

Josef Fried has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Long-acting androgenic compounds and pharmaceutical compositions thereof
    Patent number: 4948790
    Abstract: Long-acting androgenic compositions comprising C.sub.4 -C.sub.6 cycloalkyl carboxylic acids of testosterone and a pharmaceutically acceptable carrier medium. The ester can be dissolved in an acceptable oily medium or suspended in an aqueous medium in the form of micronised particles or in the form of milled particles.
    Type: Grant
    Filed: August 26, 1987
    Date of Patent: August 14, 1990
    Inventors: Sydney Archer, Gabriel Bialy, Richard P. Blye, Pierre Crabbe, deceased, by Lucie Crabbe, executor, Egon R. Diczfalusy, Carl Djerassi, Josef Fried, Hyun K. Kim
  • Esters of 17 .alpha.-ethynyl 19-nor-testosterone and 17 .alpha.-ethynyl-18-homo-19-nor-testosterone and pharmaceutical compositions containing the same
    Patent number: 4507290
    Abstract: Esters of 17 .alpha.-ethynyl 19-nor-testosterone and 17 .alpha.-ethynyl-18-homo-19-nor-testosterone and the 3-oximes thereof having long-active contraceptive activity.
    Type: Grant
    Filed: April 7, 1981
    Date of Patent: March 26, 1985
    Assignee: World Health Organization
    Inventors: Sydney Archer, Giuseppe Benagiano, Pierre Crabbe, Egon Diczfalusy, Carl Djerassi, Josef Fried
  • Chemical synthesis
    Patent number: 4456768
    Abstract: Prostaglandin and prostacyclin compounds which are fluorine substituted in any one or more of the following positions 4,4; 7,7; 10,10; and 5.
    Type: Grant
    Filed: May 1, 1981
    Date of Patent: June 26, 1984
    Assignee: The University of Chicago
    Inventor: Josef Fried
  • Certain fluorine substituted PGI.sub.2 compounds
    Patent number: 4324730
    Abstract: Prostaglandin and prostacyclin compounds which are fluorine substituted in any one or more of the following positions, 4,4; 7,7; 10,10; and 5.
    Type: Grant
    Filed: October 8, 1980
    Date of Patent: April 13, 1982
    Assignee: The University of Chicago
    Inventor: Josef Fried
  • Chemical synthesis
    Patent number: 4309351
    Abstract: This invention relates to compounds of the formulae ##STR1## wherein n is an integer from 2 to 5; M is H, acyl, lower alkyl, or lower alkoxy alkyl; Q is H or lower alkyl; R is alkyl, alkenyl or analkyl; A is H; Y is OH, acyloxy or alkoxy, and when taken together, Y and A is oxo (O.dbd.), and to novel intermediates therefore.
    Type: Grant
    Filed: February 4, 1980
    Date of Patent: January 5, 1982
    Assignee: The University of Chicago
    Inventor: Josef Fried
  • Certain amides of prostacyclin and related compounds
    Patent number: 4219647
    Abstract: This invention relates to compounds of the formula: ##STR1## wherein A is hydrogen or fluorine;Q is alkyl or alkenyl of from 3 to 6 carbon atoms;X is C.dbd.C or C.tbd.CW is ##STR2## wherein n is an integer of from 2 to 5;Y is halogen; andM is higher alkoxy; an amino acid radical; or an amino acid alkyl ester radical.The compounds of the invention are physiologically active and are useful in increasing blood flow and lowering blood pressure which are properties desirable for hypotensive agents.
    Type: Grant
    Filed: September 22, 1977
    Date of Patent: August 26, 1980
    Inventor: Josef Fried
  • Chemical synthesis
    Patent number: 4175201
    Abstract: This invention relates to pharmacologically active compounds of the formula: ##STR1## wherein Z is trans--CH.dbd.CH, C.tbd.C; or CH.sub.2 --CH.sub.2 ;M is H or lower alkyl;n is an integer of from 2 to 5;X is alkyl;W is H or OR, wherein R is H, acyl, or alkyl;each Y is H, OH or alkoxy;and to novel intermediates and processes useful in the production thereof.
    Type: Grant
    Filed: April 18, 1977
    Date of Patent: November 20, 1979
    Assignee: University of Chicago
    Inventor: Josef Fried
  • Stereocontrolled synthesis of .alpha.-multistriatin
    Patent number: 4108870
    Abstract: A practical stereocontrolled synthesis of a mixture containing a major amount of .alpha.-multistriatin and a minor amount of .gamma.-multistriatin in an overall yield of about 73% from cis-2-butene-1,4-diol is provided. .alpha.-Multistriatin is one of the three essential components of the aggregation pheromone of the European elm bark beetle.
    Type: Grant
    Filed: June 6, 1977
    Date of Patent: August 22, 1978
    Assignee: University of Chicago
    Inventors: Josef Fried, William J. Elliott
  • Chemical synthesis
    Patent number: 4018820
    Abstract: This invention relates to pharmacologically active compounds of the formula: ##STR1## wherein Z is trans-CH=CH, C.tbd.C; or CH.sub.2 -CH.sub.2 ;M is H or lower alkyl;n is an integer of from 2 to 5;X is alkyl;W is H or OR, wherein R is H, acyl, or alkyl; andEach Y is H, OH or alkoxy;And to novel intermediates and processes useful in the production thereof.
    Type: Grant
    Filed: September 5, 1974
    Date of Patent: April 19, 1977
    Assignee: The University of Chicago
    Inventor: Josef Fried