Patents by Inventor Josef Gries

Josef Gries has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5118685
    Abstract: Aminopropanol derivatives of the formula: ##STR1## where R.sup.1 and R.sup.2 are identical or different and are each hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl or hydroxyalkyl, each of not more than 6 carbon atoms, alkoxyalkyl, alkylthioalkyl or dialkylaminoalkyl, each of not more than 9 carbon atoms in total, or phenylalkyl or phenoxyalkyl where the alkyl radical is of not more than 6 carbon atoms and the phenyl radical is unsubstituted or substituted by alkyl or alkoxy, each of not more than 3 carbon atoms, or R.sup.1 and R.sup.2, together with the nitrogen atom which links them, form a 5-membered to 7-membered saturated heterocyclic ring which can be substituted by one or two phenyl and/or hydroxyl radicals and can contain an oxygen or nitrogen atom, as a further heteroatom in the ring, and such an additional nitrogen atom can be substituted by alkyl of 1 to 3 carbon atoms or by phenyl, and -- .circle.
    Type: Grant
    Filed: December 3, 1984
    Date of Patent: June 2, 1992
    Assignee: BASF Aktiengesellschaft
    Inventors: Albrecht Franke, Wolfgang Spiegler, Hardo Siegel, Claus D. Mueller, Gerda von Philipsborn, Dieter Lenke, Josef Gries
  • Patent number: 5039701
    Abstract: Benzofuran derivatives of the formula I ##STR1## where R.sup.1 to R.sup.5 and X have the meanings stated in the description, and therapeutic agents containing these derivatives.
    Type: Grant
    Filed: August 19, 1988
    Date of Patent: August 13, 1991
    Assignee: BASF Aktiengesellschaft
    Inventors: Rainer Schlecker, Manfred Raschack, Josef Gries
  • Patent number: 4945114
    Abstract: Therapeutic agents containing enantiomers of propafenone, the preparation of the said agents and their use for certain groups of patients.
    Type: Grant
    Filed: July 29, 1988
    Date of Patent: July 31, 1990
    Assignee: BASF Aktiengesellschaft
    Inventors: Albrecht Franke, deceased, Rainer Schlecker, Josef Gries, Gerda Von Philipsborn, Liliane Unger
  • Patent number: 4940780
    Abstract: Basically substituted phenylacetonitriles ##STR1## where R.sup.1 to R.sup.6 and n have the meanings stated in the description, and their preparation are described. The compounds are useful for the treatment of disorders.
    Type: Grant
    Filed: December 10, 1987
    Date of Patent: July 10, 1990
    Assignee: BASF Aktiengesellschaft
    Inventors: Werner Seitz, Liliane Unger, Manfred Raschack, Verena Baldinger, Klaus Ruebsmen, Josef Gries
  • Patent number: 4873246
    Abstract: Novel 6-(acylaminaryl)-3(2H)-pyridazinones of the formula ##STR1## where R.sup.1, R.sup.2, R.sup.3, R.sup.4, A and B have the meanings given in the description, and their preparation are described.The compounds have thrombocyte aggregation-inhibiting activity.
    Type: Grant
    Filed: October 8, 1986
    Date of Patent: October 10, 1989
    Assignee: BASF Aktiengesellschaft
    Inventors: Philip A. Rossy, Marco Thyes, Albrecht Franke, Horst Koenig, Hans D. Lehmann, Josef Gries, Ludwig Friedrich, Dieter Lenke
  • Patent number: 4851410
    Abstract: 1,4-disubstituted pyrazole derivatives of the formula I ##STR1## where R.sup.1 and R.sup.2 independently of one another are each hydrogen, lower alkyl or benzyl, or R.sup.1 and R.sup.2, together with the nitrogen atom to which they are bonded, may be a pyrrolidino, piperidino or morpholino radical, n is an integer from 2 to 5 and Z is a radical of the formula ##STR2## or QNR.sup.1 R.sup.2 where R.sup.1 and R.sup.2 have the same meanings as above, Q is ##STR3## A is CHR.sup.3 or NR.sup.3 in which R.sup.3 is CN, NO.sub.2, SO.sub.2 -aryl or SO.sub.2 -lower alkyl and m may be 0 or 1, and their pharmaceutically tolerated salts, processes for their preparation, pharmaceutical compositions containing the compounds of formula I, the use of such compositions and an intermediate of the formula III ##STR4## where R.sup.1, R.sup.2 and n have the same meanings as above, in the preparation of the compounds of the formula I.The compounds are useful to block histamine H.sub.2.sup.- receptors.
    Type: Grant
    Filed: November 15, 1988
    Date of Patent: July 25, 1989
    Assignee: BASF Aktiengesellschaft
    Inventors: Bernd Ostersehlt, Norbert Rieber, Josef Gries
  • Patent number: 4820821
    Abstract: Novel 1-phenyl-4(1H)-pyridazinone-imines of the formula (I) ##STR1## which are substituted at the imine nitrogen, and their addition salts with a physiologically tolerated acid, processes for their preparation, pharmaceutical formulations containing these compounds, and their use as drugs, in particular as antidepressants, antiparkinson drugs and antihypotonic agents.
    Type: Grant
    Filed: April 17, 1987
    Date of Patent: April 11, 1989
    Assignee: BASF Aktiengesellschaft
    Inventors: Rudolf Kropp, Marco Thyes, Rainer Schlecker, Albrecht Franke, Franz Reicheneder, Dora I. Reicheneder, August Amann, Hans-Juergen Teschendorf, Rolf Kretzschmar, Martin Traut, Josef Gries
  • Patent number: 4772598
    Abstract: 2-aryl-3,4-diazabicyclo[4.n.0]-alk-2-en-5-ones of the formula ##STR1## where m, n, R, R.sup.1, R.sup.2 and R.sup.3 have the stated meanings, are used for the treatment of cardiac insufficiency.
    Type: Grant
    Filed: October 1, 1986
    Date of Patent: September 20, 1988
    Assignee: BASF Aktiengesellschaft
    Inventors: Karl-Heinz Geiss, Phillip A. Rossy, Marco Thyes, Horst Koenig, Hans D. Lehmann, Martin Traut, Josef Gries
  • Patent number: 4723039
    Abstract: Phenylacetaldehydes which are substituted by basic groups, of the formula ##STR1## where R.sup.1 to R.sup.8, m and n have the meanings stated in the description, and their preparation are described. The substances are useful for the treatment of disorders.
    Type: Grant
    Filed: December 4, 1986
    Date of Patent: February 2, 1988
    Assignee: BASF Aktiengesellschaft
    Inventors: Werner Seitz, Verena Baldinger, Josef Gries, Dieter Lenke, Manfred Raschack, Klaus Ruebsamen
  • Patent number: 4710496
    Abstract: Novel pyrrol-1-ylphenyldihydropyridazinones of the formula ##STR1## their preparation and their use in the treatment of disorders.
    Type: Grant
    Filed: July 9, 1985
    Date of Patent: December 1, 1987
    Assignee: BASF Aktiengesellschaft
    Inventors: Karl-Heinz Geiss, Bernhard Schmied, Manfred Raschack, Hans-Dieter Lehmann, Josef Gries, Klaus Ruebsamen
  • Patent number: 4636504
    Abstract: Novel 6-(acylaminoaryl)-3(2H)-pyridazinones of the formula ##STR1## where R.sup.1, R.sup.2, R.sup.3, R.sup.4, A and B have the meanings given in the description, and their preparation are described and inhibiting thrombocyte aggregation and gastric secretion.The compounds are useful for treating disorders.
    Type: Grant
    Filed: January 17, 1984
    Date of Patent: January 13, 1987
    Assignee: BASF Aktiengesellschaft
    Inventors: Phillip A. Rossy, Marco Thyes, Albrecht Franke, Horst Koenig, Hans Dieter Lehmann, Josef Gries, Ludwig Friedrich, Dieter Lenke
  • Patent number: 4619929
    Abstract: Novel phenylpiperazinylpropane and -butane derivatives of hetarylphenols and hetarylanilines of the formula ##STR1## where R.sup.1 is hydrogen or alkyl of 1 to 4 carbon atoms, R.sup.2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms or alkoxy where alkyl is of 1 to 3 carbon atoms, the phenyl ring can be monosubstituted or disubstituted by R.sup.2, X is oxygen or an NH group, and the heterocyclic structure Het. is 1,3,4-oxadiazolyl, triazolyl, imidazolyl or pyrazolyl, and their physiologically tolerated addition salts with acids, processes for their preparation, and pharmaceutical formulations which contain these compounds and exhibit predominantly sedative, neuroleptic and hypotensive properties.
    Type: Grant
    Filed: March 19, 1984
    Date of Patent: October 28, 1986
    Assignee: BASF Aktiengesellschaft
    Inventors: Peter C. Thieme, Gerd Steiner, Wolfgang Rohr, Dieter Lenke, Josef Gries, Harald Weifenbach, Hans-Juergen Teschendorf, Hans P. Hofmann, Horst Kreiskott
  • Patent number: 4612320
    Abstract: Compounds of the general formula ##STR1## where R.sup.1, R.sup.2, R.sup.3, R.sup.4 and n have the meanings given in the description, are useful for treating cardiac disorders.
    Type: Grant
    Filed: March 12, 1984
    Date of Patent: September 16, 1986
    Assignee: BASF Aktiengesellschaft
    Inventors: Albrecht Franke, Josef Gries, Claus D. Mueller, Dieter Lenke
  • Patent number: 4571409
    Abstract: Novel aminopropanol derivatives of 2-hydroxy-.beta.-phenyl-propiophenones and their physiologically acceptable acid addition compounds, processes for their preparation and therapeutic agents which contain these derivatives and are useful as antiarrhythmic drugs.
    Type: Grant
    Filed: May 13, 1985
    Date of Patent: February 18, 1986
    Assignee: BASF Aktiengesellschaft
    Inventors: Albrecht Franke, Josef Mueller, Helmut Lietz, Walter-Wielant Wiersdorff, Hans-Guenther Hege, Claus D. Mueller, Josef Gries, Dieter Lenke, Gerda von Philipsborn, Manfred Raschack
  • Patent number: 4544562
    Abstract: 6-Aryl-4,5-dihydro-3(2H)-pyridazinones of the formula ##STR1## where R is hydrogen, R.sup.1 is hydrogen or C.sub.1 -C.sub.3 -alkyl, or R and R.sup.1 together are methylene, R.sup.2 and R.sup.3 are identical or different and are each hydrogen or C.sub.1 -C.sub.6 -alkyl, and A is hydroxyl, C.sub.1 -C.sub.6 -alkoxy, C.sub.2 -C.sub.7 -acyloxy, a C.sub.2 -C.sub.7 -carbamic acid ester group, C.sub.1 -C.sub.6 -alkylsulfonyloxy, C.sub.1 -C.sub.6 -alkylmercapto, carboxyl, C.sub.2 -C.sub.7 -alkoxycarbonyl or nitrile, and their preparation are described. The substances are suitable for treating disorders.
    Type: Grant
    Filed: March 11, 1983
    Date of Patent: October 1, 1985
    Assignee: BASF Aktiengesellschaft
    Inventors: Phillip A. Rossy, Marco Thyes, Albrecht Franke, Horst Koenig, Josef Gries, Hans D. Lehmann, Dieter Lenke
  • Patent number: 4540697
    Abstract: Novel aminopropanol derivatives of 2-hydroxy-.beta.-phenyl-propiophenones and their physiologically acceptable acid addition compounds, processes for their preparation and therapeutic agents which contain these derivatives and are useful as antiarrhythmic drugs.
    Type: Grant
    Filed: May 23, 1984
    Date of Patent: September 10, 1985
    Assignee: BASF Aktiengesellschaft
    Inventors: Albrecht Franke, Josef Muller, Helmut Lietz, Walter-Wielant Wiersdorff, Hans-Gunther Hege, Claus D. Muller, Josef Gries, Dieter Lenke, Gerda von Philipsborn, Manfred Raschack
  • Patent number: 4514413
    Abstract: N-substituted imidazole derivatives of the formula I ##STR1## where R.sup.1, R.sup.2 and R.sup.3 are identical or different and are each hydrogen or alkyl with 1 or 3 carbon atoms and Alk is an alkylene chain of 2 to 4 carbon atoms, and their salts with physiologically tolerated acids, processes for their preparation, drugs containing a compound of the formula I or one of its salts, and their use for treating disorders associated with gastric hyperacidity.
    Type: Grant
    Filed: April 7, 1983
    Date of Patent: April 30, 1985
    Assignee: BASF Aktiengesellschaft
    Inventors: Bernd Ostersehlt, Albrecht Franke, Fritz-Frieder Frickel, Marco Thyes, Ludwig Friedrich, Josef Gries, Dieter Lenke
  • Patent number: 4500467
    Abstract: Benzoylthio compounds of the formula I ##STR1## where R.sup.1 and R.sup.3 are identical or different and are each hydrogen or C.sub.1 -C.sub.4 -alkyl, R.sup.2 and R.sup.4 are identical or different and are each hydrogen or C.sub.1 -C.sub.6 -alkyl which is unsubstituted or substituted by hydroxyl, mercapto, C.sub.1 -C.sub.4 -alkylthio, a carboxylic ester group, carboxamido or acylamino or are each an aryl, hetaryl, arylalkylene or hetarylalkylene radical which is unsubstituted or substituted in the aryl moiety by hydroxyl, C.sub.1 -C.sub.4 -alkoxy, arylalkoxy or halogen, R.sup.1 and R.sup.2 and/or R.sup.3 and R.sup.4 together may furthermore be a radical --(CH.sub.2).sub.p -- (p=2, 3, 4), --CH.sub.2 --S--CH.sub.2 -- or --CH.sub.2 --C.sub.6 H.sub.4 --CH.sub.
    Type: Grant
    Filed: November 21, 1983
    Date of Patent: February 19, 1985
    Assignee: BASF Aktiengesellscaft
    Inventors: Hugo Kubinyi, Martin Traut, Josef Gries
  • Patent number: 4474785
    Abstract: 2-Aryl-3,4-diazabicyclo[4.n.O]alk-2-en-5-ones of the formula I ##STR1## where m and n are identical or different and each is 1, 2 or 3, and R, R.sup.1 and R.sup.2 are identical or different and each is hydrogen or alkyl of 1 to 6 C atoms, said compounds are useful for treating high blood pressure and thrombo-embolic disorders.
    Type: Grant
    Filed: June 4, 1982
    Date of Patent: October 2, 1984
    Assignee: BASF Aktiengesellschaft
    Inventors: Phillip A. Rossy, Marco Thyes, Albrecht Franke, Horst Koenig, Josef Gries, Hans D. Lehmann, Dieter Lenke
  • Patent number: RE33476
    Abstract: Novel 6-(acylaminoaryl)-3(2H)-pyridazinones of the formula ##STR1## where R.sup.1, R.sup.2, R.sup.3, R.sup.4, A and B have the meanings given in the description, and their preparation are described.[.and inhibiting thrombocyte aggregation and gastric secretion.]..The compounds are useful for treating disorders .Iadd.and inhibiting thrombocyte aggregation and gastric secretion.Iaddend..
    Type: Grant
    Filed: May 2, 1988
    Date of Patent: December 4, 1990
    Assignee: BASF Akteingesellschaft
    Inventors: Phillip A. Rossy, Marco Thyes, Albrecht Franke, Horst Koenig, Hans D. Lehmann, Josef Gries, Ludwig Friedrich, Dieter Lenke