Abstract: The invention relates to a process for producing and obtaining anaphylatoxin- and cocytotaxin-containing leucotaxine preparations and anaphylatoxin and cocytotaxin proteins in molecularly homogeneous, biologically active form from contact-activated mammalian serum by the following steps:separation of the proteins from other serum constituents to obtain a serum protein concentrate fraction,separation of a part of accompanying foreign blood proteins from anaphylatoxin and cocytotaxin present in the said protein concentrate fraction,isolation of the leucotaxine preparation by chromatography on hydroxyapatite,and optionally further purification and/or separation of the leucotaxine preparation into anaphylatoxin and cocytotaxin proteins by chromatographical methods.

Abstract: The invention relates to SERUM-DERIVED "LEUKORECRUITIN", which is A PROTEIN MEDIATOR OF INFLAMMATION FROM MAMMALIAN SERUM specifically inducing positive leukocytosis reaction and leukocyte recruitment from the bone marrow into the blood of animals and humans without biological side-reactions. The process for the production and isolation of leukorecruitin is characterized in that mammalian serum is subjected to regulated and limited proteolysis by contact activation, the protein is then separated from other foreign constituents and proteins of serum in the form of a crude serum protein concentrate fraction, and/or the protein is separated from other serum-proteins by chromatography on hydroxy-apatite. Leukorecruitin has very valuable pharmacological effects and can be used in compositions for specifically influencing the defense state of the animal or human body and for diagnostic purposes in hematological disorders.

Abstract: The invention relates to new chemokinesins and chemotaxins of leukocytes and inflamed tissue which have the biological and physico-chemical properties stated in the patent claims. The compounds selectively influence the motility of leukocytes or selectively attract leukocytes. The invention also relates to a biotechnical process for preparing and isolating the chemokinesins and chemotaxins and to pharmaceutical compositions containing them.

Abstract: The invention relates to new mitogens of leukocytes and inflamed tissue which have the biological and physicochemical properties stated in the claims. The compounds selectively induce the division and differentiation of leukocytes and their precursors in the bone marrow. The invention also relates to a biotechnical process for preparing and isolating the mitogens and to pharmaceutical compositions containing them.

Abstract: The invention relates to new chemorecruitins of leukocytes and inflamed tissue which have the biological and physicochemical properties stated in the patent claims. The compounds selectively induce a leukocytosis reaction and/or a leftward shift reaction in vivo. The invention also relates to a biotechnical process for preparing and isolating the chemorecruitins and to pharmaceutical compositions containing them.

Abstract: The invention relates to a process for producing and obtaining anaphylatoxin- and cocytotaxin-containing leucotaxine preparations and anaphylatoxin and cocytotaxin proteins in molecularly homogeneous, biologically active form from contact-activated mammalian serum by the following steps:separation of the proteins from other serum constituents to obtain a serum protein concentrate fraction,separation of a part of accompanying foreign blood proteins from anaphylatoxin and cocytotaxin present in the said protein concentrate fraction,isolation of the leucotaxine preparation by chromatography on hydroxyapatite,and optionally further purification and/or separation of the leucotaxine preparation into anaphylatoxin and cocytotaxin proteins by chromatographical methods.

Abstract: The invention relates to new angiotropins of leukocytes and inflamed tissue hich have the biological and physicochemical properties stated in the patent claims. The compounds selectively stimulate the directional growth of blood vessels and lead to a neovascularization of tissue. The invention also relates to a biotechnical process for preparing and isolating the angiotropins and to pharmaceutical compositions containing them.

Abstract: The invention relates to SERUM-DERIVED "LEUKORECRUITIN", which is A PROTEIN MEDIATOR OF INFLAMMATION FROM MAMMALIAN SERUM specifically inducing positive leukocytosis reaction and leukocyte recruitment from the bone marrow into the blood of animals and humans without biological side-reactions. The process for the production and isolation of leukorecruitin is characterized in that mammalian serum is subjected to regulated and limited proteolysis by contact activation, the protein is then separated from other foreign constituents and proteins of serum in the form of a crude serum protein concentrate fraction, and/or the protein is separated from other serum-proteins by chromatography on hydroxyapatite. Leukorecruitin has very valuable pharmacological effects and can be used in compositions for specifically influencing the defense state of the animal or human body and for diagnostic purposes in hematological disorders.

Abstract: A process for obtaining functionally and morphologically intact and viable leucocytes and thrombocytes from blood is disclosed. Erythrocytes are removed from the blood and then the leucocytes are separated by centrifugation and treated to remove trace amounts of erythrocytes and thrombocytes. The thrombocytes are obtained from the supernatant produced by the centrifugation.