Patents by Inventor Josef Klosa

Josef Klosa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4742065
    Abstract: Salts of basic caffeine-8-ethers having the following general formula are disclosed: ##STR1## where X=2 or 3 and R is an alkyl group having from 1 to 3 carbon atoms, whereby the chain may be branched, in the form of fumarates. The components have pharmaceutical properties including effectiveness as anti-psoriatics.
    Type: Grant
    Filed: March 1, 1985
    Date of Patent: May 3, 1988
    Assignee: Sanorania Dr. G. Strohscheer
    Inventors: Josef Klosa, Hans Kroger
  • Patent number: 4416878
    Abstract: New [8-(dialkylamino alkoxy)-caffeine]-platinum complex compounds of the general formula ##STR1## are prepared from 8-(dialkylamino alkoxy)-caffeine and hexachloro platinic acid. The complex compounds are nonpoisonous, stable and infinitely durable. In pharmacological test series distinct cytostatic activity of the complex compounds is observed and they are suitable for use as active components in pharmaceutical products.
    Type: Grant
    Filed: December 4, 1981
    Date of Patent: November 22, 1983
    Inventor: Josef Klosa
  • Patent number: 4189487
    Abstract: A therapeutic composition for the treatment of acne vulgaris comprising a pyridine aldehyde compound of the formula: ##STR1## wherein n is 0 or 1. Also the process for the treatment of acne vulgaris comprising applying said pyridine aldehyde to the lesions thereof.
    Type: Grant
    Filed: March 15, 1978
    Date of Patent: February 19, 1980
    Inventor: Josef Klosa
  • Patent number: 4022786
    Abstract: 4,4-Diarylpiperidine compounds, preferably 4,4-diphenylpiperidine which are substituted or unsubstituted in the 1-position of the piperidine nucleus, such as 1-(lower alkyl)-4,4-diphenylpiperidines, 1-(lower alkyl)-4-phenyl-4-tolylpiperidines, and their substantially non-toxic, pharmaceutically-acceptable acid addition salts, are highly effective central nervous system (CNS) stimulants which are superior to known amphetamine-type stimulants. A novel and highly advantageous process of making such 4,4-diarylpiperidine compounds comprises reacting a 4-aryl-4-hydroxypiperidine compound which may be substituted in its 3-position by an aroyl group, with an aromatic hydrocarbon, in particular with benzene, in the presence of a Friedel-Crafts-type catalyst.
    Type: Grant
    Filed: March 26, 1974
    Date of Patent: May 10, 1977
    Assignee: Byk Gulden Lomberg Chemische Fabrik GmbH
    Inventors: Gerhard Hackmack, Josef Klosa
  • Patent number: 4016280
    Abstract: 4,4-Diarylpiperidine compounds, preferably 4,4-diphenylpiperidine which are substituted or unsubstituted in the 1-position of the piperidine nucleus, such as 1-(lower alkyl)-4,4-diphenylpiperidines, 1-(lower alkyl)-4-phenyl-4-tolylpiperidines, and their substantially non-toxic, pharmaceutically-acceptable acid addition salts, are highly effective central nervous system (CNS) stimulants which are superior to known amphetamine-type stimulants. A novel and highly advantageous process of making such 4,4-diarylpiperidine compounds comprises reacting a 4-aryl-4-hydroxypiperidine compound which may be substituted in its 3-position by an aroyl group, with an aromatic hydrocarbon, in particular with benzene, in the presence of a Friedel-Crafts-type catalyst.
    Type: Grant
    Filed: May 13, 1975
    Date of Patent: April 5, 1977
    Assignee: Byk Gulden Lomberg Chemische Fabrik GmbH
    Inventors: Heinz Gunter Menge, Josef Klosa