Abstract: Charged nanostructure being comprising gold nanoparticle which may bear on at least portion thereof a positively charged polymer wherein the positively charged polymer may bearon at least portion thereof a negatively charged polymer is disclosed. Uses thereof for diagnosis is also disclosed.

Abstract: Disclosed herein telomerase inhibitors and controlled-release formulations thereof, the use of telomerase-inhibiting porphyrins, especially metalloporphyrins, in the controlled-release intratumoral implants for the treatment of cancer. Provided herein also specific compositions of metalloporphyrins and poly-(lactic-co-glycolic)-acid copolymers, in various implantable forms, and methods of treatment cancer by administering the implants of the invention, alongside possible co-treatment with brachytherapy radioactive seeds to precipitate Auger effect of the metal atoms contained in the metalloporphyrins.

Abstract: Methods are disclosed involving the formation of complex DNA-Metal and the detection of the complex, such as by employing several analytical methods, e.g., X-Ray Fluorescence, FT-IR and Raman spectroscopy.

Abstract: A controlled release pharmaceutical composition includes a biocompatible polymeric material, preferably polyethylene-vinyl acetate or poly(lactic-glucolic acid), having incorporated therein a soluble receptor capable of binding to its ligand and thus affecting the ligand's function. The soluble receptor is preferably the soluble form of TNF.alpha. receptor. Such compositions are for use in the treatment of disorders in which neutralization of the deleterious effects of TNF.alpha. is required.