Abstract: The invention relates to systems and methods for assessing the efficacy of an aerosol for pulmonary drug delivery as well as to an inhaler device, an orally inhaled drug product and a drug/device combination product. An aerosol can be generated by an inhaler device and comprises aerosol particles containing an orally inhaled drug product. The method comprises the steps of providing a computational lung model and a computational particle transport and deposition model, computing a spatial particle deposition distribution of discrete particles based on a determined aerosol value of an aerosol parameter, computing an efficacy value of an efficacy parameter based on the spatial particle deposition distribution and using the efficacy value for automatically assessing the efficacy for pulmonary drug delivery of the aerosol.

Abstract: A surveying instrument for executing a relocation functionality, which determines first coordinates of a stationary target point associated with the start signal, in response to a start signal, a first actuator and a second actuator are controlled such that the stationary target point remains within a detection area of a tracking unit of the surveying instrument, determines second coordinates of the stationary target point, receives an end signal, wherein the second coordinates of the stationary target point are associated with the end signal, and based at least in part on the first and second coordinates of the stationary target point, and determines a relative pose of the surveying instrument with respect to a first setup location and a second setup location, wherein the first setup location is associated with the first coordinates and the second setup location is associated with the second coordinate.

Abstract: The present invention relates to a method for the diagnosis and/or classification of a disease in a subject based on the genetic and/or epigenetic information of a sample obtained from the subject, the method comprising the steps of: a) providing data from said sample, wherein said data comprises genetic and/or epigenetic information of a random subset of genomic positions: b) assigning said sample to a sample class based on genetic and/or epigenetic information of said random subset of genomic positions by employing a computational model, which discriminates a plurality of sample classes based on genetic and/or epigenetic information of a set of genomic positions comprising said random subset, wherein the computational model has been trained with pre-determined genetic and/or epigenetic information obtained from a plurality of pre-classified samples of known diseases and wherein said computational model processes the genetic and/or epigenetic information of a genomic position of said random subset independen

Abstract: A pressing device for pressing meat products, in particular frozen and/or partly frozen meat products, preferably fresh meat products and/or bacon, comprises a pressing chamber which extends along a longitudinal axis and into which a product to be pressed can be inserted, wherein the pressing chamber comprises at least one counter-element and at least one contact element, which is movable in the direction of the counter-element, that cooperate such that the product inserted into the pressing chamber can be compressed between the at least one counter-element and the at least one contact element; and wherein the pressing device comprises at least one servomotor that is configured to move the at least one contact element.

Abstract: A method comprising: setting up a stationary surveying device at a first known positioning in a surrounding area of the object; retrieving from a memory a set of object points of an object to be surveyed and/or to be marked; surveying and/or marking from a first positioning object points of the set of object points that can be surveyed and/or can be marked from the first positioning by means of the free beam, on the basis of a target direction; ascertaining missing object points of a set of object points; relocating the surveying device to a second, unknown positioning in the surrounding area of the object; automatically determining a second positioning by the surveying device on the basis of the knowledge of the first positioning, so that the second positioning is known; surveying and/or marking missing object points by means of the free beam from the second positioning.

Abstract: In a method of pressing and processing meat products, in particular frozen and/or partly frozen meat products, preferably fresh meat products and/or bacon, the products are inserted into a pressing chamber of a pressing device and are pressed in the pressing chamber by at least one displaceable contact element, with the contact element being moved by means of a servomotor.

Abstract: An auxiliary measuring instrument, configured to form together with a ground-based surveying device having range-and-direction measuring functionality, a system for surveying or staking out object points, wherein the auxiliary measuring instrument including a handheld main body of a defined length, and a man-machine interface, wherein the auxiliary measuring instrument is designed in a pen-like form and size and is configured to aim at an object point to be surveyed or staked out in a one-handed manner with a first end of the auxiliary measuring instrument and wherein a body is attached at a second end of the auxiliary measuring instrument, wherein the body is designed for optical-image-based determination of the position of the auxiliary measuring instrument by the surveying device.

Abstract: A method comprising: setting up a stationary surveying device at a first known positioning in a surrounding area of the object; retrieving from a memory a set of object points of an object to be surveyed and/or to be marked; surveying and/or marking from a first positioning object points of the set of object points that can be surveyed and/or can be marked from the first positioning by means of the free beam, on the basis of a target direction; ascertaining missing object points of a set of object points; relocating the surveying device to a second, unknown positioning in the surrounding area of the object; automatically determining a second positioning by the surveying device on the basis of the knowledge of the first positioning, so that the second positioning is known; surveying and/or marking missing object points by means of the free beam from the second positioning.

Abstract: A movable contact element for a pressing device for pressing meat products, in particular frozen and/or partly frozen meat products, preferably fresh meat products and/or bacon, comprises a base part; an attachment part; a transverse sliding part; and a height part that are connected to one another at respective connection points and that form a contact surface for a product at one side of the contact element during the pressing. The contact surface has an effective length along a first direction of extent and an effective width along a second direction of extent perpendicular to the first direction of extent, with the effective length and the effective width of the contact surface being variable.

Abstract: A calibrating method and system for an auxiliary measuring instrument which is designed to form together with a ground-based, stationary, surveying device having range-and-direction measuring functionality, a total station, a system for surveying and/or staking out object points. The auxiliary measuring instrument including a body which has a code for determining the orientation by using a pivoting movement of the body about a resting contact end of the auxiliary measuring instrument.

Abstract: A method and device for displaying desired positions in a live image of a construction site. The method mat include recording at least one position-referenced image of the construction site; linking at least one desired position to the position-referenced image; storing the position-referenced image together with desired position linkage in an electronic memory; recording a live image of the construction site, in particular in the form of a video, wherein the live image and the position-referenced image at least partially represent an identical detail of the construction site; retrieving the stored position-referenced image from the memory; fitting the position-referenced image with the live image, so that the desired position linked to the position-referenced image can be overlaid in a position-faithful manner on the live image; and position-faithful display of the desired position as a graphic marking in the live image.

Abstract: The invention relates to a method for producing a release film by coating a carrier film using a release coating, wherein the method comprises the steps of: (a) providing the carrier film, wherein the carrier film has a first surface side and a second surface side; wherein the carrier film is preferably structured; (b) providing a coating composition which has a solvent component, preferably comprising ethyl acetate, propyl acetate, butyl acetate, and/or n-propanol, and a silicone system curable by UV radiation; (c) coating at least part of the first surface side of the carrier film provided in step (a) using the coating composition provided in step (b); (d) evaporating at least a part of the solvent component; and (e) irradiating at least part of the first surface side of the carrier film coated in step (c) using UV radiation to cure the silicone system.

Abstract: An apparatus for inserting a measurement light beam which can be projected onto a target object, comprising a light-refracting component having an optical axis, and at least two mirrors for deflecting the measurement light beam, and an optical overall body consisting of at least one optically effective material, wherein the optical overall body is configured in such a way that the at least two mirrors are fitted inside or at the edge, in particular as a part, of the optical overall body, in such a way that the measurement light beam entering the optical overall body is offset parallel to the incident measurement light beam when emerging from the optical overall body, so that the emerging measurement light beam lies on the optical axis of the light-refracting component of the apparatus and is projected in this form onto the target object.

Abstract: A surveying instrument for executing a relocation functionality, which determines first coordinates of a stationary target point associated with the start signal, in response to a start signal, a first actuator and a second actuator are controlled such that the stationary target point remains within a detection area of a tracking unit of the surveying instrument, determines second coordinates of the stationary target point, receives an end signal, wherein the second coordinates of the stationary target point are associated with the end signal, and based at least in part on the first and second coordinates of the stationary target point, and determines a relative pose of the surveying instrument with respect to a first setup location and a second setup location, wherein the first setup location is associated with the first coordinates and the second setup location is associated with the second coordinates.

Abstract: A surveying pole system comprising a surveying pole including two telescopic sections for providing length adjustability. At a first end of the surveying pole, a pointing tip is disposed for positioning on a target point of the environment. At a second end, a length reference point is disposed. The surveying pole also includes a locking mechanism for locking the length adjustability in respective lock-in positions. Each of the lock-in positions provides a corresponding distance between the pointing tip and the length reference point. A plurality of coded identifiers have a predetermined code associated with one of the lock-in positions. The surveying pole also includes a coded-identifier reader for reading the code of a respective coded identifier associated with the respective lock-in position, a communication device configured for transmitting a signal to a surveying instrument, wherein the signal is based at least on the read code.

Abstract: A device for determining a dimension of a tool having a cutting edge includes a first light source configured to emit light parallel to a first axis, an image sensor which is associatable with a second axis extending orthogonally to the image sensor and an analyzing unit. The first axis and the second axis are inclined relative to each other. The device is configured such that the light emitted from the first light source is reflectable by the cutting edge of the tool in such a way that light spots arranged in a line on the image sensor are generatable by the reflected light. The analyzing unit is configured to determine positions of the light spots. The dimension of the tool is determinable based on the positions of the light spots.

Abstract: A reflector arrangement for determining the position or marking of target points, having at least one retroreflector, and a beam detection unit, by means of which the orientation measurement radiation passing through the retroreflector is acquirable. The beam detection unit comprises a first sensor for generating a signal in dependence on an acquisition of orientation measurement radiation and a first beam guiding unit. The first sensor and the first beam guiding unit are arranged such that a detection field of view for acquiring the orientation measurement radiation is defined, an alignment of the detection field of view around the yaw axis is variable and orientation measurement radiation passing through the retroreflector is acquirable in dependence on the alignment of the detection field of view with the first sensor.

Abstract: A surveying instrument for executing a relocation functionality, which determines first coordinates of a stationary target point associated with the start signal, in response to a start signal, a first actuator and a second actuator are controlled such that the stationary target point remains within a detection area of a tracking unit of the surveying instrument, determines second coordinates of the stationary target point, receives an end signal, wherein the second coordinates of the stationary target point are associated with the end signal, and based at least in part on the first and second coordinates of the stationary target point, and determines a relative pose of the surveying instrument with respect to a first setup location and a second setup location, wherein the first setup location is associated with the first coordinates and the second setup location is associated with the second coordinate.

Abstract: An industrial or geodetic surveying device with a scan functionality including an alidade rotating about a standing axis and a telescope unit with a beam exit for a laser measuring beam. The telescope unit is mounted on the alidade and is movable in a tilting motion about an elevation axis substantially orthogonal to the standing axis. The scan functionality comprises a scan sequence with an angular velocity of the alidade around the standing axis, wherein during the scan sequence the alidade is in a continuous revolving motion with mainly constant angular velocity about the standing axis, and the angular velocity of the alidade is faster than half of the angular velocity of the tilting motion of the telescope unit about the elevation axis.

Abstract: The invention relates to a measurement system, e.g. comprising a total station and an auxiliary measurement instrument in the form of a pole, and/or an auxiliary measurement instrument, e.g. a pole, and/or a method for determining positions in the field of geodesics or on construction sites, e.g. by means of a construction laser.