Abstract: The present invention relates to small molecule compounds based on benzopyrimido- or benzoimidazo-thiazin-imine as well as their (synthesis) intermediates and their use as HDAC inhibitors, in particular HDAC8 inhibitors. The present invention also relates to the use of said compounds in the treatment of cancer and as therapeutic agents for eukaryotic parasites and respective methods of treatment.

Abstract: The disclosure relates to the biosynthesis of terpenoids, such as, for example, geraniol and derivatives thereof, using genetic engineering. In particular, the disclosure relates to the biosynthesis of nepetalactol, nepetalactone, dihydronepetalactone, and derivatives thereof. The disclosure provides recombinant cells genetically engineered to produce high levels of nepetalactol, nepetalactone and/or dihydronepetalactone. The disclosure also provides methods of producing nepetalactol, nepetalactone and dihydronepetalactone using cell-based systems as well as cell-free systems.

Abstract: The present invention relates to small molecule compounds based on benzopyrimido- or benzoimidazo-thiazin-imine as well as their (synthesis) intermediates and their use as HDAC inhibitors, in particular HDAC8 inhibitors. The present invention also relates to the use of said compounds in the treatment of cancer and as therapeutic agents for eukaryotic parasites and respective methods of treatment.

Abstract: The present invention relates to small molecule compounds based on benzopyrimido- or benzoimidazo-thiazin-imine as well as their (synthesis) intermediates and their use as HDAC inhibitors, in particular HDAC8 inhibitors. The present invention also relates to the use of said compounds in the treatment of cancer and as therapeutic agents for eukaryotic parasites and respective methods of treatment.

Abstract: A chip for performing and measuring chemical reactions, interactions (bonds), and/or conformational changes, especially fast chemical reactions and processes. The chip includes a base plate, which is made of a polymer material that is transparent at least in the measuring zone, and having. fluid ducts parallel to the plane of the base plate and includes at least two reagent feeders leading into a mixer structure that has a number of inlets corresponding to the number of reagent feeders and an outlet leading into a mixing section, the outlet of the mixing section leads into a measuring section, the outlet of the measuring section is connected to a discharge section, the discharge section leads out of the base plate or into a reservoir that is arranged on the chip, and pressure conduits lead into the reagent feeders at a distance from the mixer structure.

Abstract: Gas seals are embodied in the form of contactless joints for sealing a gas processing chamber with respect to a sealed chamber, wherein a gas leak is generally extremely low. A locking labyrinth comprising at least one chamber to which the gas is supplied and which is placed upstream of the gas seal makes it possible to avoid said situation. The chamber is provided with a rate control element for operating with a constant supply pressure and for supplying the chamber with a predetermined rate gas flow.

Abstract: A pilot-operated pressure shut-off valve having a main control piston which, when an upper system limit pressure in the hydraulic system is reached, connects an inlet, via which pressure medium can be fed to a hydraulic system, to an outlet by taking up a first switching position and, when a lower system limit pressure is reached, separates from the outlet by taking up a second switching position. The pressure shut-off valve has a pilot valve arrangement by which the fluidic connection of a control space adjacent to the main control piston can be changed in order to control the main control piston, and which has a valve housing, with a first pilot piston and a second pilot piston accommodated within the first pilot piston for compact construction and capability to adjust the two pilot pistons mechanically completely independently of each other.

Abstract: The invention relates to a method for directly detecting the modification of a molecule containing a fluorescent dye by measuring the fluorescence lifetime.

Abstract: The present invention relates to a homogeneous assay method of quantitative measurement of kinase, phosphatase and phosphodiesterase (PDE) reactions. The method may be used both in a direct and in a competitive assay format.

Abstract: What is disclosed is a directly controlled pressure control valve comprising a seat piston in a longitudinal bore of a valve housing, which is radially guided in its guidance portion through the intermediary of two circular, spaced-apart guide members in the longitudinal bore.

Abstract: A method for determining the chemosensitivity of cells towards at least one substance by measuring the apoptosis induced by said at least one substance, wherein the apoptosis is determined from the accumulated caspase activity of a sample comprising cells and a medium by adding said at least one substance to the sample followed by incubation, and measuring the accumulated caspase activity in the sample upon disruption of the cells without previously separating off the cells.

Abstract: A method for determining the chemosensitivity of cells towards at least one substance by measuring the apoptosis induced by said at least one substance, wherein the cells are incubated essentially concurrently with at least one marker whose interaction with phosphatidylserine can be detected and with said at least one substance, and the interaction between the marker and phosphatidylserine is detected in a time-resolved manner.

Abstract: The present invention discloses a homogeneous fluorescent binding assay method using carrier particles.

Abstract: The invention relates to a pilot-operated pressure shut-off valve having a main control piston which, when an upper system limit pressure in the hydraulic system is reached, connects an inlet, via which pressure medium can be fed to a hydraulic system, to an outlet by taking up a first switching position and, when a lower system limit pressure is reached, separates from the outlet by taking up a second switching position.

Abstract: The present invention discloses a homogeneous fluorescent binding assay method using carrier particles.

Abstract: A method for the labeling of molecules through the reaction of molecules to be labeled with labels at a solid phase (matrix), characterized in that the molecules enter a reaction chamber in which a matrix loaded with a reactive component is provided, and after the coupling has taken place, the labeled molecules leave the reaction chamber through a porous means.

Abstract: A precontrolled 3-way pressure control valve with a main valve having, in a valve housing, a valve bore with first, second and third control chambers connected with pressure connection, tank connection, and control connection, respectively, a control piston displaceable in a valve bore, wherein the third control chamber is connectable with the first or second control chambers, and subjectable in opposite direction to pressures from the control connection and pressure setting of a pilot valve. With deviation of pressure applied in control connection from pressure setting of the pilot valve, an imbalance of forces develops in the valve. Oblong holes, distributed over circumference of hollow control piston pass through the wall, are located in the wall radially delimiting its hollow chamber, which holes are longer than clearances between two control chambers.

Abstract: A precontrolled three-way pressure reduction valve having essentially vibration-free operation is encased in a cartridge and has a hollow control piston wherein a working fluid space is formed as a T-shaped cavity within the control piston. In the cavity, there are axial and transverse bores of approximately the same diameter. A groove encircles the control piston, and has a width which is slightly larger than a diameter of the transverse bore, the transverse bore communicating with the groove.

Abstract: The flexible filter element (12) of the filter (10) is pleated in a zig-zag-shaped configuration and has its longitudinal edges (24) connected to support elements (26). Each of the support elements (26) comprises a plurality of support members (40) arranged beside one another and being interconnected by a continuous flange (28). The support elements (26) as well as the rest of the filter element (12) are made of a plastic material. The strength of the flanges (28) is selected in such a manner that the support members (40) are flexible relative to each other which is possible by elastic or plastic deformation of the support elements (26) in the region of the flanges (28), particularly in that region of the flanges (28) wherein these flanges connect adjacent support members (40). The filter (10) can be produced as a filter element (12) extending in a linear plane, which, because of its flexibility, can be deformed while being mounted and/or remain deformed in its mounted condition.

Abstract: A shaft stop bushing (1) is proposed which is retained in a given position on a shaft (6) by means of a radially resilient stop ring (12). The stop bushing (1) has a longitudinal bore (4) with two circular grooves (7 and 11) of different diameters, between which a funnel-shaped section (10) is formed. The stop ring (12) is inserted in the larger groove (11) so that stops bushing (1) and stop ring (12) form a pre-assembled subassembly (1, 12). The preassembled subassembly (1, 12) can be slid onto the shaft (6) by a simple automatized process without the stop ring (12) touching the shaft (6). The stop ring (12) is retained in its axial position relative to an annular groove (16) of the shaft (6) and is pressed into the annular groove (16) by the stop bushing (1) upon further axial movement of the stop bushing. The entry funnel-shaped section (10) presses the stop ring (12) until, in the assembled state, the smaller-diameter circular groove (7) engages over the stop ring (12).