Abstract: The present invention relates to antifouling compositions comprising compounds of formula IA and/or IB that are highly effective against marine biofouling of surfaces of ships and marine structures, their use for inhibiting marine biofouling, as well as antifouling paints comprising said compositions.

Abstract: The present invention relates to antifouling compositions comprising copper di(ethyl 4,4,4-trifluoroacetoacetate) (Cu(ETFAA)2) that are highly effective against marine biofouling of surfaces of ships and marine structures, their use for inhibiting marine biofouling, as well as antifouling paints comprising said compositions.

Abstract: Eight containers (1) containing substances (602, 702) are held in holes (71) in a support (70). The eight containers (1) containing different substances or the same substances in different amounts graduated in mole equivalents form a set (69) of containers containing substances, which set can be used for carrying out a chemical reaction.

Abstract: The invention relates to a device that comprises a tool holder that can be adjusted in an x-axis, a y-axis which is perpendicular thereto, and a z-axis that is perpendicular both to the x-axis and the y-axis and that can be pivoted about the z-axis. A dispense head for solid material is mounted on the tool holder as the tool. Two scales are disposed on the dispense head for solid material, said scales weighing the material which is or is to be delivered by the dispense head for solid material. The inventive design with two scales directly mounted on the dispense head for solid material allows for weighing of the material without the dispense head for solid material or the material having to be placed on separate scales.

Abstract: The inventive device comprises a tool holder (1), which can be displaced in an x-direction, in a y-direction that is perpendicular thereto, and in a z-direction that is perpendicular to both the x-direction and the y-direction, and which can rotate about the z-direction. A solid matter dosing head (350), provided as a tool, is automatically attached in a removable manner to the tool holder (1) by means of a permanent magnet (351). The tool can be easily exchanged for another tool due to this automatic removable attachment of said tool to the tool holder (1) involving the use of a permanent magnet (351).

Abstract: The inventive device comprises a tool holder, which can be displaced in an x-direction, in a y-direction that is perpendicular thereto, and in a z-direction that is perpendicular to both the x-direction and the y-direction, and which can rotate about the z-direction A solid matter dosing head, provided as a tool, is automatically attached in a removable manner to the tool holder by means of a permanent magnet. The tool can be easily exchanged for another tool due to this automatic removable attachment of said tool to the tool holder involving the use of a permanent magnet.

Abstract: Twelve reaction vessels (2) in two parallel rows are attached to a switch block (401). The switch block (401) comprises a reaction block (403) and twelve slide plates (404), which are arranged within it and which can be adjusted between an open position, a closed position and a further position. In the open position, access in straight line to the associated reaction vessel (2) is possible whereas in the closed position, the corresponding reaction vessel (2) is closed in a pressure-tight manner by the switch block (401). In the case of a positive pressure or depression in the reaction vessel (2), the corresponding slide plate (404) is pressed by this positive pressure or depression against the reaction block (403) or is drawn onto it. By means of this switch block (401), it is also possible to carry out processes in which high positive pressures are present in the reaction vessels (2).

Abstract: The invention relates to a novel process for the preparation of an aminoalcohol of the formula racemically or optically active, starting from 2-azabi-cyclo[2.2.1]hept-5-en-3-one, its further conversion to give the corresponding acyl derivative and its further conversion to (1S,4R)— or (1R,4S)-4-(2-amino-6-chloro-9-H-purine-9-yl)-2-cyclopentenyl-1-methanol of the formulae In the latter synthesis, the aminoalcohol is converted into the corresponding D- or L-tartrate, which is then reacted with N-(2-amino-4,6-dichloropyrimidin-5-yl) formamide of the formula to give (1S, 4R)- or (1R, 4S)-4-[(2-amino-6-chloro-5-formamido-4-pyrimidinyl)amino]-2-cyclopentenyl-1-methanol of the formulae and then cyclized to give the end compounds.

Abstract: The invention relates to a novel process for the preparation of an aminoalcohol of the formula racemically or optically active, starting from 2-azabicyclo[2.2.1]hept-5-en-3-one, its further conversion to give the corresponding acyl derivative and its further conversion to (1S,4R)- or (1R,4S)-4-(2-amino-6-chloro-9H-purine-9-yl)-2-cyclopentenyl-1-methanol of the formulae In the latter synthesis, the aminoalcohol is converted into the corresponding D- or L-tartrate, which is then reacted with N-(2-amino-4,6-dichloropyrimidin-5-yl)formamide of the formula to give (1S,4R)- or (1R,4S)-4-[(2-amino-6-chloro-5-formamido-4-pyrimidinyl)amino]-2-cyclopentenyl-1-methanol of the formulae and then cyclized to give the end compounds.

Abstract: A device for analyzing substances by thin layer chromatography comprises a solvent trough with two solvent channels, wherein two wall plates are mounted in the solvent trough, enabling thin layer plates to be arranged obliquely with respect to the horizontal in the solvent channels. The substance to be analyzed can thus be dropped or applied onto the thin layer plates from above, and solvent can be supplied to the solvent channels from above at a solvent supply point. The upward migration of components of the substance to be analyzed can thus be started without changing the position of the thin layer plate for this purpose.

Abstract: A method for producing 6,6-dialkoxy-5-hydroxy-3-oxo-hexanoic acid esters of general formula (I), wherein the dianion of an acetoacetic acid alkyl ester is reacted with an aldehyde. The 6,6-dialkoxy-5-hydroxy-3-oxo-hexanoic acid esters of general formula (I) are important synthesis building blocks for producing HMG-CoA-reductase-inhibitors.

Abstract: The invention relates to a novel process for the preparation of an aminoalcohol of the formula racemically or optically active, starting from 2-azabicyclo[2.2.1]hept-5-en-3-one, its further conversion to give the corresponding acyl derivative and its further conversion to (1S,4R)— or (1R,4S)-4-(2-amino-6-chloro-9-H-purine-9-yl)-2-cyclopentenyl-1-methanol of the formulae In the latter synthesis, the aminoalcohol is converted into the corresponding D- or L-tartrate, which is then reacted with N-(2-amino-4,6-dichloropyrimidin-5-yl)formamide of the formula to give (1S,4R)— or (1R,4S)-4-[(2-amino-6-chloro-5-formamido-4-pyrimidinyl)amino]-2-cyclopentenyl-1-methanol of the formulae and then cyclized to give the end compounds.