Patents by Inventor Josef Werlen

Josef Werlen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Genes for butyrobetaine/crotonobetaine-l-carnitine metabolism and their use for the microbiological production of l-carnitine
    Patent number: 5759824
    Abstract: An isolated DNA fragment including the genes bcoC, bcoA/B, bcoD coding for the enzymes for L-carnitine biosynthesis in .gamma.-butyrobetaine/crotonobetaine metabolism and, additionally, including the gene bcoT coding for a potential transport protein in .gamma.-butyrobetaine/crotonobetaine metabolism. Also, any vector which includes an isolated DNA fragment including the genes bcoC, bcoA/B, bcoD coding for the enzymes for L-carnitine biosynthesis in .gamma.-butyrobetaine/crotonobetaine metabolism and, additionally, including the gene bcoT coding for a potential transport protein in .gamma.-butyrobetaine/crotonobetaine metabolism. Also, biotechnological process for the production of L-carnitine characterized in that crotonobetaine and/or .gamma.-butyrobetaine is fermented in the presence of a suitable carbon and nitrogen source using a microorgansim and L-carnitine is isolated.
    Type: Grant
    Filed: July 2, 1996
    Date of Patent: June 2, 1998
    Assignee: Lonza, A.G.
    Inventors: Thomas Zimmermann, Josef Werlen