Abstract: A pharmaceutical composition including therapeutically effective amounts of at least one HMG-CoA reductase inibitor present as a dyhydroxyacid salt and at least one additional therapeutic agent.

Abstract: In concepts relating to biotechnology, fermentor and bioreactor apparatus and technology are provided for maximizing aeration for the cultivation and growth of aerobic microorganisms and tissue cells in artificial media such as aqueous growth media. The apparatus comprises a chamber with an impeller assembly for downward peripheral rotary flow under circumferential baffles that are downwardly disposed alongside microporous air sparger tubes. The agitation system preferably comprises a tree-turbine or a spherical-shaped impeller system. The apparatus provides advantages with respect to low shear, low power requirement, and high oxygen absorption rate, the latter being higher than conventional rates by an order of magnitude. In a preferred embodiment for the suppression of headspace foam, the invention comprises an assembly for forcing foam-destructive downdraft air into the headspace as well as stirrer or agitator assembly for stirring and breaking up foam that is present in the headspace.