Patents by Inventor Josep M. Aran Perramon

Josep M. Aran Perramon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS FOR IMMUNOMODULATION
    Publication number: 20240131059
    Abstract: The invention relates to compounds based on a recombinant form of the CCP6 region of C4BP and an oligomerization domain for use in the prevention and/or treatment of immunological diseases. Moreover, the invention relates to methods for obtaining tolerogenic dendritic cells and tolerogenic macrophages using the compounds of the invention and to the cells obtained by these methods and their therapeutic uses.
    Type: Application
    Filed: October 18, 2020
    Publication date: April 25, 2024
    Inventors: Josep M. ARAN PERRAMON, Ana LUQUE GÒMEZ, Inmaculada SERRANO SANTACRUZ
  • C4BP-BASED COMPOUNDS FOR TREATING IMMUNOLOGICAL DISEASES
    Publication number: 20200148731
    Abstract: The invention relates to compounds for use in the prevention and/or treatment of immunological diseases, particularly rheumatoid arthritis systemic lupus erythematosus and lupus nephritis, characterized by the subcutaneous administration of isoforms of C4BP lacking the beta chain or polypeptides comprising the CCP6 region of the alpha chain of C4BP no more than once a week or at a dose ranging from 0.24 mg/m2 to 9.99 mg/m2. The invention also relates to pharmaceutical compositions comprising from 0.45 mg to 18.90 mg of said compounds for the prevention and/or treatment of said diseases.
    Type: Application
    Filed: April 5, 2018
    Publication date: May 14, 2020
    Inventors: Josep M. ARAN PERRAMON, Luis Antonio RUIZ AVILA, Jordi ORTIZ SAGRISTA, Nuria LLUCH LAFUENTE
  • Predictive methods of atherosclerosis and stenosis
    Patent number: 10577659
    Abstract: The present invention relates to methods for diagnosing unstable atherosclerotic plaque, determining the probability of suffering from stroke, selecting a therapy for a subject suffering from carotid artery disease and predicting the progression of atherosclerotic disease.
    Type: Grant
    Filed: January 23, 2017
    Date of Patent: March 3, 2020
    Assignees: INSTITUT D'INVESTIGACIÓ BIOMÈDICA DE BELLVITGE (IDIBELL, FUNDACIÚ ASSISTENCIAL DE MÚTUA DE TERRASSA, FPC
    Inventors: Josep M. Aran Perramon, Ana Luque Gómez, Jerzy Krupinski
  • PREDICTIVE METHODS OF ATHEROSCLEROSIS AND STENOSIS
    Publication number: 20190032138
    Abstract: The present invention relates to methods for diagnosing unstable atherosclerotic plaque, determining the probability of suffering from stroke, selecting a therapy for a subject suffering from carotid artery disease and predicting the progression of atherosclerotic disease.
    Type: Application
    Filed: January 23, 2017
    Publication date: January 31, 2019
    Inventors: Josep M. ARAN PERRAMON, Ana LUQUE GÓMEZ, Jerzy KRUPINSKI
  • Compositions and methods for immunomodulation
    Patent number: 10106589
    Abstract: The invention relates to methods and reagents for the treatment of immunological diseases. In particular, the invention relates to isoforms of the C4b-binding protein (C4BP) lacking beta chains as well as to fragments and peptides derived thereof and to the uses of these polypeptides for the treatment of immunological diseases such as immunoinflammatory disease, sepsis, an autoimmune disease, transplant rejection, graft-versus-host disease and a hypersensitivity disease. Moreover, the invention relates also the use of factor H for the treatment of immunological diseases. In addition, the invention relates to tolerogenic dendritic cells obtained using the C4BP isoform lacking beta chain, the peptides and fragments thereof and factor H and to the therapeutic uses of said cells.
    Type: Grant
    Filed: July 16, 2012
    Date of Patent: October 23, 2018
    Assignee: FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE (IDIBELL)
    Inventors: Josep M Aran Perramon, Rut Olivar Miro
  • STRATEGIES FOR PREVENTION AND/OR TREATMENT OF DISEASES BASED ON CD40 SILENCING
    Publication number: 20140315981
    Abstract: The present invention is related to methods for prevention and/or treatment of a number of diseases, such as lupus nephritis, ischemia/reperfusion injury and sepsis, based on the silencing of CD40 using different RNA silencing strategies.
    Type: Application
    Filed: September 7, 2012
    Publication date: October 23, 2014
    Applicant: FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE (IDIBELL)
    Inventors: Josep Maria Grinyo i Boira, Oriol Bestard Matamoros, Josep Maria Gruzado Garrit, Juan Torres Ambros, Josep M. Aran Perramon
  • COMPOSITIONS AND METHODS FOR IMMUNOMODULATION
    Publication number: 20140309158
    Abstract: The invention relates to methods and reagents for the treatment of immunological diseases. In particular, the invention relates to isoforms of the C4b-binding protein (C4BP) lacking beta chains as well as to fragments and peptides derived thereof and to the uses of these polypeptides for the treatment of immunological diseases such as immunoinflammatory disease, sepsis, an autoimmune disease, transplant rejection, graft-versus-host disease and a hypersensitivity disease. Moreover, the invention relates also the use of factor H for the treatment of immunological diseases. In addition, the invention relates to tolerogenic dendritic cells obtained using the C4BP isoform lacking beta chain, the peptides and fragments thereof and factor H and to the therapeutic uses of said cells.
    Type: Application
    Filed: July 16, 2012
    Publication date: October 16, 2014
    Applicant: FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE (IDIBELL)
    Inventors: Josep M. Aran Perramon, Rut Olivar Miro