Abstract: Compounds of formula (I), pharmaceutical formulations thereof and the use of such compounds for treating endothelin mediated diseases or conditions are described herein.

Abstract: Isoxazole-sulfonamide endothelin antagonists of formula (I) below having good affinity for endothelin receptors and selectivity for ETA over ETB are described herein. Such compounds are useful in the treatment of conditions mediated by endothelin, in particular, conditions mediated by endothelin ETA.

Abstract: Compounds of formula I, 1

Abstract: Isoxazole-sulfonamide endothelin antagonists of formula (I) below having good affinity for endothelin receptors and selectivity for ETA over ETB are described herein.

Abstract: A biological process is enhanced by a method and apparatus used to contact a biomass with a gas and with a nutrient liquid. A resiliently compressible porous matrix system containing the biomass is mounted in a reaction vessel containing a body of the nutrient liquid and a body of the gas above the body of the liquid. The body of liquid having an upper surface exposed to the body of gas and defining a liquid-gas interface. The resiliently compressible porous matrix system is located in a position in the reaction vessel so that compressible porous matrix system is partly immersed in the nutrient liquid and partly extends above the upper surface of the liquid into the body of gas.

Abstract: Compounds of formula (I), their salts and prodrugs thereof, where the substituents are as defined herein are disclosed as opiate binding agents useful in the treatment of opiate-mediated conditions. Also described are processes for making such substances.

Abstract: Compounds of formula (I) or pharmaceutically, veterinarily or agriculturally acceptable salts thereof, or pharmaceutically, veterinarily or agriculturally acceptable solvates of either entity, wherein R1 is 2,4,6-trisubsituted phenyl or 3,5-disubstituted pyridin-2-yl; R3 is C1-C4 alkyl optionally substituted with hydroxy or with one or more halo; cyano, C1 to C5 alkanoyl or phenyl R5 is hydrogen, C1 to C4 alkyl, amino or halo; R2 and R4 are each independently selected from hydrogen, C1 to C4 alkyl, fluoro, chloro and bromo or, together with the carbon atom to which they are attached, form a C3 to C6 cycloalkyl group; R6 and R8 are each independently selected from hydrogen, C1 to C4 alkyl, fluoro, chloro and bromo; or; when R2 and R4 do not form part of a cycloalkyl group, R2 and R6, together with the carbon atoms to which they are attached, may form a C5 to C7 cycloalkyl group; and R7 is hydrogen, C1 to C4 alkyl optionally substituted with one or more halo; or C1 to C4 alkoxy; are parasitici

Abstract: Parasiticidal pyrazole derivatives of formula (I) wherein: R1 represents CN, C1-6 alkoxycarbonyl, NO2, CHO, C1-6 alkanoyl, phenyl optionally substituted by one or more halogen, or C1-6 alkyl optionally substituted by one or more halogen; R2 represents a group of formula (II), (III) or (IV) in which: R7 represents H, halogen, carbamoyl, cyano, tri(C1-6 alkyl)silyl, C1-6 alkyl (optionally substituted by one or more halogen, OH or C1-6 alkoxy), C1-6 alkoxycarbonyl, phenyl, or a 5- or 6-membered ring heterocycle which is saturated or partially or fully unsaturated and contains up to 4 hetero-atoms independently selected from up to 4 N atoms, up to 2 O atoms and up to 2 S atoms and which is attached to the alkynyl moiety by an available C, S or N atom where the valence allows; and R8, R9 and R10 each independently represents H, halogen, phenyl optionally substituted by one or more halogen, CN or C1-6 alkyl optionally substituted by one or more halogen; R3 represents H, C1-6 alkyl, halogen, NH2, NH(C1-6 alkanoyl),

Abstract: Compounds of formula (I) 1

Abstract: Compounds of formula (I) ##STR1## wherein the substituents are as defined herein, are antiparasitic agents.

Abstract: Compounds of formula (I): ##STR1## or pharmaceutically, veterinarily or agriculturally acceptable salts thereof, or pharmaceutically, veterinarily or agriculturally acceptable solvates of either entity, wherein R.sup.1 is 2,4,6-trisubstituted phenyl or 3,5-disubstituted pyridin-2-yl; R.sup.3 is hydrogen; C.sub.2 to C.sub.5 alkyl substituted with one or more halo and with hydroxy; C.sub.2 to C.sub.5 alkanoyl substituted with one or more halo; C.sub.2 to C.sub.6 alkenyl optionally substituted with one or more halo; halo; amino or CONH.sub.2 ; R.sup.5 is hydrogen, amino or halo; R.sup.2 and R.sup.4 are each independently selected from hydrogen, fluoro, chloro and bromo; R.sup.6 and R.sup.8 are hydrogen; and R.sup.7 is hydrogen or C.sub.1 to C.sub.4 alkyl optionally substituted with one or more halo; are parasiticidal agents.

Abstract: Compounds of formula (I): ##STR1## wherein the substituents are as defined herein, are antiparasitic agents.

Abstract: Compounds of formula (IA) and (IB), ##STR1## wherein the substituents are as defined herein, and the salts and solvates thereof, are useful as antiparasitic agents.

Abstract: Compounds of formula (I) or pharmaceutically, veterinarily or agriculturally acceptable salts thereof, or pharmaceutically, veterinarily or agriculturally acceptable solvates of either entity, wherein R.sup.1 is 2,4,6-trisubstituted phenyl or 3,5-disubstituted pyridin-2-yl; R.sup.3 is C.sub.1 -C.sub.4 alkyl optionally substituted with hydroxy or with one or more halo; cyano, C.sub.1 to C.sub.5 alkanoyl or phenyl; R.sup.5 is hydrogen, C.sub.1 to C.sub.4 alkyl, amino or halo; R.sup.2 and R.sup.4 are each independently selected from hydrogen, C.sub.1 to C.sub.4 alkyl, fluoro, chloro and bromo or, together with the carbon atom to which they are attached, form a C.sub.3 to C.sub.6 cycloalkyl group; R.sup.6 and R.sup.8 are each independently selected from hydrogen, C.sub.1 to C.sub.4 alkyl, fluoro, chloro and bromo; or, when R.sup.2 and R.sup.4 do not form part of a cycloalkyl group, R.sup.2 and R.sup.6, together with the carbon atoms to which they are attached, may form a C.sub.5 to C.sub.

Abstract: A new group of parasiticidal pyrazoles of formula (I) wherein R.sup.2 is NH.sub.2, H, halogen, NH(C.sub.1-6 alkyl optionally substituted with one or more halogen), NH(allyl optionally substituted with one or more halogen), NH(benzyl optionally substituted with one or more halogen), NHSCF.sub.3, or R.sup.2 is C.sub.1-6 alkyl optionally substituted with one or more halogen; R.sup.3, R.sup.5 and R.sup.7 are each independently H, halogen, Sf.sub.5, C.sub.1-6 alkyl optionally substituted with one or more halogen, C.sub.1-6 alkoxy optionally substituted with one or more halogen, or S(O).sub.n (C.sub.1-6 alkyl optionally substituted with one or more halogen) wherein n is 0, 1 or 2; X is O or NOY; Y is H or C.sub.1-6 alkyl optionally substituted with one or more halogen; R.sup.8 is H, C.sub.1-8 alkyl optionally substituted with one or more halogen, or C.sub.3-8 cycloalkyl optionally substituted by one or more halogen, or by one or more C.sub.1-4 alkyl optionally substituted with one or more halogen, or by C.sub.

Abstract: Compounds of formula (I): ##STR1## or pharmaceutically, veterinarily or agriculturally acceptable salts thereof, or pharmaceutically, veterinarily or agriculturally acceptable solvates of either entity, wherein R.sup.1 is 2,4,6-trisubstituted phenyl or 3,5-disubstituted pyridin-2-yl; R.sup.3 is hydrogen; C.sub.2 to C.sub.5 alkyl substituted with one or more halo and with hydroxy; C.sub.2 to C.sub.5 alkanoyl substituted with one or more halo; C.sub.2 to C.sub.6 alkenyl optionally substituted with one or more halo; halo; amino or CONH.sub.2 ; R.sup.5 is hydrogen, amino or halo; R.sup.2 and R.sup.4 are each independently selected from hydrogen, fluoro, chloro and bromo; R.sup.6 and R.sup.8 are hydrogen; and R.sup.7 is hydrogen or C.sub.1 to C.sub.4 alkyl optionally substituted with one or more halo; are parasiticidal agents.

Abstract: This invention is directed to novel antiparasitic compounds of formula (I), wherein the broken line represents an optional bond, R.sup.1 and R.sup.4 being absent when this bond is present, R.sup.1, R.sup.3, R.sup.4 are independently H, OH, halo mercapto, oxo, oximino, or an organic radical, R.sup.2 and R.sup.7 are organic radicals, R.sup.6 is H or an organic radical and R.sup.12 is OH, halo, C.sub.1 -C.sub.8 alkoxy, C.sub.1 -C.sub.9 alkanoyloxy, or oximino optionally O-substituted by a C.sub.1 -C.sub.8 alkyl, alkenyl, alkynyl, aryl, trialkylsilyl, aralkyl or C.sub.1 -C.sub.9 alkanoyl group.