Patents by Inventor Joseph A. Beavo

Joseph A. Beavo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibodies specifically immunoreactive with human brain Ca.sup.2+ /calmodulin cyclic nucleotide phosphodiesterase
    Patent number: 5789553
    Abstract: The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca.sup.2+ /calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: August 4, 1998
    Assignee: The Board of Regents of the University of Washington
    Inventors: Joseph A. Beavo, J. Kelley Bentley, Harry Charbonneau, William K. Sonnenburg
  • Isolated and purified calcium/calmodulin stimulated cyclic nucleotide phosphodiesterases
    Patent number: 5776752
    Abstract: The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca.sup.2+ /calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 7, 1998
    Assignee: The Board of Regents of The University of Washington
    Inventors: Joseph A. Beavo, J. Kelley Bentley, Harry Charbonneau, William K. Sonnenburg
  • Cyclic GMP-binding, cyclic GMP-specific phosphodiesterase materials and methods
    Patent number: 5702936
    Abstract: The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding, cGMP-specific phosphodiesterase designated cGB-PDE. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds which modulate the enzymatic activity of cGB-PDE polypeptides.
    Type: Grant
    Filed: May 27, 1994
    Date of Patent: December 30, 1997
    Assignees: ICOS Corporation, Vanderbilt University, Board of Regents of the University of Washington
    Inventors: Joseph A. Beavo, Jackie D. Corbin, Kenneth M. Ferguson, Sharron H. Francis, Ann Kadlecek, Kate Loughney, Linda M. McAllister-Lucas, William K. Sonnenburg, Melissa K. Thomas
  • Cyclic GMP-binding, cyclic GMP-specific phosphodiesterase materials and methods
    Patent number: 5652131
    Abstract: The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding, cGMP-specific phosphodiesterase designated cGB-PDE. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds which modulate the enzymatic activity of cGB-PDE polypeptides.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 29, 1997
    Assignees: ICOS Corporation, Vanderbilt University, Board of Regents of the University of Washington
    Inventors: Joseph A. Beavo, Jackie D. Corbin, Kenneth M. Ferguson, Sharron H. Francis, Ann Kadlecek, Kate Loughney, Linda M. McAllister-Lucas, William K. Sonnenburg, Melissa K. Thomas
  • DNA encoding mammalian phosphodiesterases
    Patent number: 5602019
    Abstract: The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca.sup.2+ /calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
    Type: Grant
    Filed: August 29, 1994
    Date of Patent: February 11, 1997
    Assignee: The Board of Regents of The University of Washington
    Inventors: Joseph A. Beavo, Kelley J. Bentley, Harry Charbonneau, William K. Sonnenburg
  • DNA encoding mammalian phosphodiesterases
    Patent number: 5580771
    Abstract: The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca.sup.2+ /calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
    Type: Grant
    Filed: August 29, 1994
    Date of Patent: December 3, 1996
    Assignee: The Board of Regents of the University of Washington
    Inventors: Joseph A. Beavo, Harry Charbonneau, William K. Sonnenburg
  • DNA encoding mammalian phosphodiesterases
    Patent number: 5389527
    Abstract: The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca.sup.2+ /calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
    Type: Grant
    Filed: April 20, 1992
    Date of Patent: February 14, 1995
    Assignee: The Board of Regents of The University of Washington
    Inventors: Joseph A. Beavo, Harry Charbonneau, William K. Sonnenburg