Patents by Inventor Joseph A. Cipollina

Joseph A. Cipollina has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antidepressant 3-(aminocycloalkenyl)-indole-5-nitrile derivatives
    Patent number: 5607961
    Abstract: Certain 3-amino-cycloalkanyl and cycloalkenyl derivatives of 5-cyano-substituted indoles of Formula I are useful antidepressant agents. ##STR1## The substituent R.sup.1 is hydrogen or C.sub.1-4 alkyl and R.sup.2 is C.sub.1-4 alkyl or --(CH.sub.2).sub.p --Ar with Ar being a phenyl, pyridinyl, pyrimidinyl or 1,4-benzodioxan-2-yl moiety. The symbol m is zero or 1, n is 1 to 3 and p is zero or 1 to 4.
    Type: Grant
    Filed: August 22, 1995
    Date of Patent: March 4, 1997
    Assignee: Bristol-Myers Squibb Company
    Inventors: Joseph A. Cipollina, Ronald J. Mattson, Charles P. Sloan
  • Antimigraine derivatives of indolylcycloalkanylamines
    Patent number: 5583149
    Abstract: A series of novel serotonergic indolyl derivatives of cycloalkanyl- and cycloalkenyl-amines of Formula I are intended for use in the alleviation of vascular headaches.
    Type: Grant
    Filed: August 21, 1995
    Date of Patent: December 10, 1996
    Assignee: Bristol-Myers Squibb Company
    Inventors: Joseph A. Cipollina, Jonas A. Gylys, Ronald J. Mattson, Charles P. Sloan
  • Antidepressant 3-(aminocycloalkenyl)-indole-5-nitrile derivatives
    Patent number: 5468767
    Abstract: Certain 3-amino-cycloalkanyl and cycloalkenyl derivatives of 5-cyano-substituted indoles of Formula I are useful antidepressant agents. ##STR1## The substituent R.sup.1 is hydrogen or C.sub.1-4 alkyl and R.sup.2 is C.sub.1-4 alkyl or --(CH.sub.2).sub.p --Ar with Ar being a phenyl, pyridinyl, pyrimidinyl or 1,4-benzodioxan-2-yl moiety. The symbol m is zero or 1, n is 1 to 3 and p is zero or 1 to 4.
    Type: Grant
    Filed: January 6, 1994
    Date of Patent: November 21, 1995
    Assignee: Bristol-Myers Squibb Company
    Inventors: Joseph A. Cipollina, Ronald J. Mattson, Charles P. Sloan
  • Antimigraine derivatives of indolylcycloalkanylamines
    Patent number: 5468768
    Abstract: A series of novel serotonergic indolyl derivatives of cycloalkanyl- and cycloalkenyl-amines of Formula I are intended for use in the alleviation of vascular headaches.
    Type: Grant
    Filed: January 6, 1994
    Date of Patent: November 21, 1995
    Assignee: Bristol-Myers Squibb Company
    Inventors: Joseph A. Cipollina, Jonas A. Gylys, Ronald J. Mattson, Charles P. Sloan
  • Metabolites and prodrug formulations of 8-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]de cane-7,9-dione
    Patent number: 4956368
    Abstract: Various metabolites and prodrug formulations of 8-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]deca ne-7,9-dione which are particularly useful in the treatment of psychotic disorders, especially derivatives thereof which have been oxygenated at specified sites about the original structure, rearranged compounds, and prodrug formulations of these species. One particularly desired group of compounds have the general Formula I where ##STR1## R.sup.1 is hydrogen, hydroxyl, alkoxy, acyloxy and oxo; R.sup.2 is hydrogen, methyl, hydroxyl, alkoxy, and acyloxy;R.sup.3 is hydrogen, hydroxyl, and methoxy:R.sup.4 is hydrogen, methyl and oxo; andX is S, SO, and SO.sub.2.
    Type: Grant
    Filed: July 24, 1989
    Date of Patent: September 11, 1990
    Assignee: Bristol-Myers Company
    Inventors: Joseph A. Cipollina, Edward H. Ruediger