Abstract: Reanalysis of the SIMPLIFY 1 and 2 trials data indicates MMB is effective in JAKi-naïve patients and in second line therapy to RUX, providing benefits of reducing enlarged spleens, improving myelofibrosis-related symptoms, and increasing transfusion independence in patient at risk for thrombocytopenia from the underlying disease and RUX therapy. Accordingly, methods of treating myeloproliferative neoplasms (MPN) such as myelofibrosis are described. The methods can include administering a therapeutically effective amount of momelotinib or a pharmaceutically acceptable salt thereof to a subject identified as having (i) myelofibrosis and (ii) a platelet count of less than 150×109/L.

Abstract: Reanalysis of the SIMPLIFY 1 and 2 trials data indicates MMB is effective in JAKi-naïve patients and in second line therapy to RUX, providing benefits of reducing enlarged spleens, improving myelofibrosis-related symptoms, and increasing transfusion independence in patient at risk for thrombocytopenia from the underlying disease and RUX therapy. Accordingly, methods of treating myeloproliferative neoplasms (MPN) such as myelofibrosis are described. The methods can include administering a therapeutically effective amount of momelotinib or a pharmaceutically acceptable salt thereof to a subject identified as having (i) myelofibrosis and (ii) a platelet count of less than 150×109/L.

Abstract: A technique allows a user to project content onto a shared display region in a controlled manner. The technique involves receiving context information that describes a context in which a user is currently interacting with a local user computing device. The technique then determines, based on policy logic and the context information, whether it is appropriate to invoke a private state, or to remove the private state and enter a shared state. The private state involves presenting a privacy screen on one or more shared display regions. The local user computing device remains connected to the display device(s) that host the shared display region(s) while operating in both the private state and the shared state. According to one advantage, the technique eliminates or reduces the risk that the user will inadvertently release private information to others; further, it does so without asking the user to perform burdensome preparatory actions.

Abstract: Managing user accounts on a shared computing device to maintain at least one of system resources or performance. The method includes identifying one or more desired triggers indicating that that one or more user accounts should be deleted from the shared computing device to comply with a predetermined resource target. The method further includes, as a result of the one or more triggers, deleting user accounts to attempt to comply with the predetermined resource target.

Abstract: Updating a computing device. The method includes identifying a defined computing system role for the computing device. The method further includes, based on the defined computing system role for the computing device, identifying a schedule for performing maintenance tasks for the computing device at the computing device corresponding to the defined computing role for the computing device. The method further includes performing one or more maintenance tasks for the computing device according to the identified schedule.

Abstract: Managing user accounts on a shared computing device to maintain at least one of system resources or performance. The method includes identifying one or more desired triggers indicating that that one or more user accounts should be deleted from the shared computing device to comply with a predetermined resource target. The method further includes, as a result of the one or more triggers, deleting user accounts to attempt to comply with the predetermined resource target.

Abstract: Updating a computing device. The method includes identifying a defined computing system role for the computing device. The method further includes, based on the defined computing system role for the computing device, identifying a schedule for performing maintenance tasks for the computing device at the computing device corresponding to the defined computing role for the computing device. The method further includes performing one or more maintenance tasks for the computing device according to the identified schedule.

Abstract: A construction system and method of constructing is disclosed. The construction system includes a substantially spherical hub and linear member attached to the substantially spherical hub to construct a variety of structures. The method of constructing a structure utilizing a plurality of substantially spherical hubs and linear members includes inserting the linear members into the substantially spherical hubs and rotating them to lock them securely in place.

Abstract: An integrated, in-line bumping and exposure system for printing plates or other substrates having a photosensitive layer. A linear illumination source or sources are for bumping the photosensitive material with a band of illumination to consume dissolved oxygen within the photosensitive layer. A raster scan optical assembly or an illuminated and re-imaged spatial light modulator array exposes the photosensitive material with a rasterized beam or beams or an array of modulated electromagnetic radiation located downstream of the bumping illumination. A conveyance mechanism is configured to provide relative continuous motion between one or more substrates and the bands of illumination to continuously bump and pattern one portion of the plate or plates while the other portion of the plate or plates is bumped in anticipation of patterning.

Abstract: A construction system and method of constructing is disclosed. The construction system includes a substantially spherical hub and linear member attached to the substantially spherical hub to construct a variety of structures. The method of constructing a structure utilizing a plurality of substantially spherical hubs and linear members includes inserting the linear members into the substantially spherical hubs and rotating them to lock them securely in place.