Abstract: The present application includes a transdermal base formulation useful for example, for the transdermal delivery of active pharmaceutical ingredients along with a process for preparation thereof. In particular, the transdermal base formulation comprises: (a) an aqueous phase comprising water and at least one emulsion stabilizer; (b) an oil phase comprising at least one emulsifier, at least one emulsion stabilizer, at least one emollient comprising at least one flavonoid, at least one other emollient, and a terpene-rich natural butter; (c) an external phase comprising at least one terpene-rich extract or oil, at least one penetration enhancer and a phospholipid-complexed flavonoid; and optionally (d) at least one preservative phase.

Abstract: The present application is directed to transdermal formulations comprising one or more capsaicinoinds, one or more 1,4-dialdehyde sesquiterpenes, a penetration enhancer comprising tetrahydropiperine and a transdermal formulation base. The formulations advantageously show improved color characteristics and cause less irritation compared to other known transdermal or topica formulations comprising capsaicinoinds.

Abstract: The present application includes a transdermal base formulation useful for example, for the transdermal delivery of active pharmaceutical ingredients along with a process for preparation thereof. In particular, the transdermal base formulation comprises: (a) an aqueous phase comprising water and at least one emulsion stabilizer; (b) an oil phase comprising at least one emulsifier, at least one emulsion stabilizer, at least one emollient comprising at least one flavonoid, at least one other emollient, and a terpene-rich natural butter; (c) an external phase comprising at least one terpene-rich extract or oil, at least one penetration enhancer and a phospholipid-complexed flavonoid; and optionally (d) at least one preservative phase.

Abstract: The present application is directed to transdermal formulations for the delivery of celecoxib to a subject for the treatment of celecoxib-responsive diseases or conditions. In particular, the transdermal formulation is an emulsion comprising an oil phase, an aqueous phase and an external phase.

Abstract: The present application is directed to transdermal formulations for the delivery of propionic and acetic acid NSAIDs to a subject for the treatment of NSAID-responsive diseases. In particular, the transdermal formulation is an emulsion comprising an oil phase, an aqueous phase and an external phase.

Abstract: The present application is directed to transdermal formulations for the delivery of doxycycline compounds to a subject for the treatment of doxycycline-responsive diseases. In particular, the transdermal formulation is an emulsion comprising an oil phase, an aqueous phase and an external phase.

Abstract: The present application is directed to transdermal formulations for the delivery of berberine compounds to a subject for the treatment of berberine-responsive diseases. In particular, the transdermal formulation comprises: (a) an aqueous phase comprising water and at least one water soluble emulsion stabilizer; (b) an oil phase comprising at least one emulsifier, at least one oil soluble emulsion stabilizer, at least one emollient comprising at least one flavonoid and at least one other emollient; wherein the oil and aqueous phases form an emulsion; (c) an external phase comprising at least one flavonoid containing-extract, at least one phospholipid-complexed flavonoid and at least one source of berberine or analog or derivative thereof; and optionally (d) at least one preservative phase.

Abstract: The present application is directed to transdermal formulations comprising one or more capsaicinoinds, one or more 1,4-dialdehyde sesquiterpenes, a penetration enhancer comprising tetrahydropiperine and a transdermal formulation base. The formulations advantageously show improved color characteristics and cause less irritation compared to other known transdermal or topica formulations comprising capsaicinoinds.

Abstract: Disclosed herein are human CRP40 fragments and polynucleotides encoding them. The CRP40 fragments and polynucleotides may be useful in the treatment of diseases associated with one or more of oxidative stress, mitochondrial dysfunction and abnormal protein folding, including various neurological disorders.

Abstract: A novel mammalian catecholamine-regulated protein called CRP40 is identified. This protein, and nucleic acid encoding same, is useful in methods of diagnosing and treating hypodopaminergic neurological disease, such as Parkinson's disease, multisystem atrophy, lewy body dementia, schizophrenia, and bipolar disease.

Abstract: A novel mammalian catecholamine-regulated protein called CRP40 is identified. This protein, and nucleic acid encoding same, is useful in methods of diagnosing and treating hypodopaminergic neurological disease, such as Parkinson's disease, multisystem atrophy, lewy body dementia, schizophrenia, and bipolar disease.

Abstract: A novel family of mammalian catecholamine proteins is identified. These proteins are useful in methods of diagnosing neurological diseases, including schizophrenia and bipolar disease, as well as cardiovascular disease. This family of CRP40 proteins are also useful to treat neurological diseases.

Abstract: A novel family of mammalian catecholamine proteins is identified. These proteins are useful in methods of diagnosing neurological diseases, including schizophrenia and bipolar disease, as well as cardiovascular disease. This family of CRP40 proteins are also useful to treat neurological diseases.

Abstract: This invention relates to a novel, multisegmented nozzle for dispensing viscous materials, particularly for dispensing differently colored toothpaste into toothpaste tubes so as to produce toothpaste of striped appearance when dispensed from the tube. The nozzle has a tubular body defined by an outer body wall, and has within the tubular body a central channel and a plurality of longitudinal first and second side channels situated around the central channel. The first side channels have a cross section which narrows towards the central channel; the second side channels have a rectangular cross section. Because of this configuration the nozzle is able to load multicolored toothpaste tubes which dispense toothpaste in a substantially more uniform striped pattern than conventionally loaded multicolored toothpaste tubes.

Abstract: A tubular toothpaste container is provided having different toothpaste materials disposed within multiple internal segments of the container. The container has a first toothpaste material within a central core of the container, and one or more additional toothpaste materials disposed within segments arranged around the central core. Toothpaste dispensed from such a container has a stripped appearance.

Abstract: This disclosure relates to a device for immobilizing infants and young children during radiographic examination. The device consists of a cellular foam insert contoured with a cavity to partially envelop and restrain the child, restraining straps made from a foam and fabric combination, and a plastic base designed to support the foam insert and provide a fastening point for the restraining straps. All of the materials used in the device are radiolucent, thus showing no trace of shadows or foreign artifacts on radiographic film.