Patents by Inventor Joseph A. Gardecki

Joseph A. Gardecki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12310561
    Abstract: In some embodiments, devices, systems, and methods for advancing and positioning tethered capsule microendoscopes are provided. In some embodiments, a device for capsule endomicroscopy is provided, comprising: a tether having a proximal end and distal end; an optical fiber disposed within the tether; a tube enclosing at least a portion of the tether, the tube having a proximal end and a distal end, a diameter of the tube being larger than the diameter of the tether; a housing coupled to the distal end of the tether and the distal end of the tube; and an optical element disposed within the housing, the optical element being optically coupled to the distal end of the optical fiber and configured to direct light received from the optical fiber toward a periphery of the housing.
    Type: Grant
    Filed: September 22, 2023
    Date of Patent: May 27, 2025
    Assignee: The General Hospital Corporation
    Inventors: Guillermo J. Tearney, Chulho Daryl Hyun, Joseph A. Gardecki
  • Publication number: 20250064381
    Abstract: An apparatus for determining a shape of a luminal sample including: a catheter including a lens, the catheter disposed within a strain-sensing sheath such that the lens rotates and translates; a structural imaging system optically coupled to the catheter; a strain-sensing system optically coupled to the catheter; and a controller coupled to the strain-sensing system and the structural imaging system. The controller determines: a first position of the catheter relative to the luminal sample at a first location within the strain-sensing sheath; a second position of the catheter relative to the luminal sample at a second location within the strain-sensing sheath; a first strain of the strain-sensing sheath at the first location; a second strain of the strain-sensing sheath at the second location; a local curvature of the luminal sample relative to the catheter; a local curvature of the catheter; and a local curvature of the luminal sample.
    Type: Application
    Filed: November 11, 2024
    Publication date: February 27, 2025
    Applicant: The General Hospital Corporation
    Inventors: Guillermo J. Tearney, Joseph A. Gardecki, Kanwarpal Singh
  • Publication number: 20250004262
    Abstract: An apparatus for obtaining interferometric data, including: an optical detector to detect the interferometric data, the optical detector including at least one pixel, and the at least one pixel including at least one counter configured to count photoelectrons.
    Type: Application
    Filed: June 28, 2023
    Publication date: January 2, 2025
    Inventors: Matthew R Johnson, Michael C Bradshaw, Guillermo J Tearney, Joseph A. Gardecki, Osman Oguz Ahsen
  • Patent number: 12178596
    Abstract: An apparatus for determining a shape of a luminal sample including: a catheter including a lens, the catheter disposed within a strain-sensing sheath such that the lens rotates and translates; a structural imaging system optically coupled to the catheter; a strain-sensing system optically coupled to the catheter; and a controller coupled to the strain-sensing system and the structural imaging system. The controller determines: a first position of the catheter relative to the luminal sample at a first location within the strain-sensing sheath; a second position of the catheter relative to the luminal sample at a second location within the strain-sensing sheath; a first strain of the strain-sensing sheath at the first location; a second strain of the strain-sensing sheath at the second location; a local curvature of the luminal sample relative to the catheter; a local curvature of the catheter; and a local curvature of the luminal sample.
    Type: Grant
    Filed: October 10, 2023
    Date of Patent: December 31, 2024
    Assignee: The General Hospital Corporation
    Inventors: Guillermo J. Tearney, Joseph A. Gardecki, Kanwarpal Singh
  • Publication number: 20240350011
    Abstract: A method for detecting inflammatory activity, including: providing a catheter including a near-infrared fluorescence (NIRF) imaging system configured to perform NIRF imaging and an optical coherence tomography (OCT) imaging system configured to perform structural imaging; introducing a near-infrared fluorescent cathepsin-activatable imaging agent into a blood vessel; placing a distal end of the catheter within the blood vessel; obtaining, using the OCT imaging system, structural images of an atherosclerotic plaque within the blood vessel; obtaining, using the NIRF imaging system. NIRF images of the atherosclerotic plaque within the blood vessel; detecting the near-infrared fluorescent cathepsin-activatable imaging agent in the NIRF images; and identifying inflammation within the atherosclerotic plaque based on detecting the near-infrared fluorescent cathepsin-activatable imaging agent in the NIRF images.
    Type: Application
    Filed: August 23, 2022
    Publication date: October 24, 2024
    Applicant: The General Hospital Corporation
    Inventors: Andrew D. Thrapp, Osman O. Ahsen, Guillermo J. Tearney, Farouc A. Jaffer, Joseph A. Gardecki, Mohamad B. Kassab, Adam Mauskapf
  • Publication number: 20240226442
    Abstract: An injection apparatus, including: a needle configured to be inserted into a tissue; a light source to deliver light to the tissue to generate reflected light; a detector to detect the reflected light from the tissue; a processor coupled to the detector and configured to: analyze the reflected light from the tissue to identify a tissue type associated with the reflected light, and provide an output to a user based on the identified tissue type.
    Type: Application
    Filed: February 25, 2022
    Publication date: July 11, 2024
    Inventors: Molly Wanner, William Farinelli, Richard Rox Anderson, Joseph A. Gardecki, Matthew J. Beatty, Guillermo J. Tearney
  • Publication number: 20240131267
    Abstract: An injection apparatus, including: a needle configured to be inserted into a tissue; a light source to deliver light to the tissue to generate reflected light; a detector to detect the reflected light from the tissue; a processor coupled to the detector and configured to: analyze the reflected light from the tissue to identify a tissue type associated with the reflected light, and provide an output to a user based on the identified tissue type.
    Type: Application
    Filed: February 25, 2022
    Publication date: April 25, 2024
    Inventors: Molly Wanner, William Farinelli, Richard Rox Anderson, Joseph A. Gardecki, Matthew J. Beatty, Guillermo J. Tearney
  • Publication number: 20240074643
    Abstract: In some embodiments, devices, systems, and methods for advancing and positioning tethered capsule microendoscopes are provided. In some embodiments, a device for capsule endomicroscopy is provided, comprising: a tether having a proximal end and distal end; an optical fiber disposed within the tether; a tube enclosing at least a portion of the tether, the tube having a proximal end and a distal end, a diameter of the tube being larger than the diameter of the tether; a housing coupled to the distal end of the tether and the distal end of the tube; and an optical element disposed within the housing, the optical element being optically coupled to the distal end of the optical fiber and configured to direct light received from the optical fiber toward a periphery of the housing.
    Type: Application
    Filed: September 22, 2023
    Publication date: March 7, 2024
    Inventors: Guillermo J. Tearney, Chulho Daryl Hyun, Joseph A. Gardecki
  • Patent number: 11890077
    Abstract: Exemplary method and apparatus for diagnosing or characterizing an inflammation within an anatomical structure can be provided. For example, using at least one source arrangement, it is possible to provide at least one first electro-magnetic radiation to the anatomical structure at at least one first wavelength in vivo. With at least one detector arrangement, it is possible to detect at least one second electro-magnetic radiation at at least one second wavelength provided from the anatomical structure. The second radiation can be associated with the first radiation, and the first wavelength can be shorter than the second wavelength. The second radiation can be provided from the anatomical structure due to at least one change in the anatomical structure caused by the inflammation without providing an artificial fluorescence substance.
    Type: Grant
    Filed: January 28, 2021
    Date of Patent: February 6, 2024
    Assignee: The General Hospital Corporation
    Inventors: Hao Wang, Joseph A. Gardecki, Guillermo J. Tearney
  • Publication number: 20240032855
    Abstract: An apparatus for determining a shape of a luminal sample including: a catheter including a lens, the catheter disposed within a strain-sensing sheath such that the lens rotates and translates; a structural imaging system optically coupled to the catheter; a strain-sensing system optically coupled to the catheter; and a controller coupled to the strain-sensing system and the structural imaging system. The controller determines: a first position of the catheter relative to the luminal sample at a first location within the strain-sensing sheath; a second position of the catheter relative to the luminal sample at a second location within the strain-sensing sheath; a first strain of the strain-sensing sheath at the first location; a second strain of the strain-sensing sheath at the second location; a local curvature of the luminal sample relative to the catheter; a local curvature of the catheter; and a local curvature of the luminal sample.
    Type: Application
    Filed: October 10, 2023
    Publication date: February 1, 2024
    Applicant: The General Hospital Corporation
    Inventors: Guillermo J. Tearney, Joseph A. Gardecki, Kanwarpal Singh
  • Patent number: 11813068
    Abstract: An apparatus for determining a shape of a luminal sample including: a catheter including a lens, the catheter disposed within a strain-sensing sheath such that the lens rotates and translates; a structural imaging system optically coupled to the catheter; a strain-sensing system optically coupled to the catheter; and a controller coupled to the strain-sensing system and the structural imaging system. The controller determines: a first position of the catheter relative to the luminal sample at a first location within the strain-sensing sheath; a second position of the catheter relative to the luminal sample at a second location within the strain-sensing sheath; a first strain of the strain-sensing sheath at the first location; a second strain of the strain-sensing sheath at the second location; a local curvature of the luminal sample relative to the catheter; a local curvature of the catheter; and a local curvature of the luminal sample.
    Type: Grant
    Filed: June 24, 2022
    Date of Patent: November 14, 2023
    Assignee: The General Hospital Corporation
    Inventors: Guillermo J. Tearney, Joseph A. Gardecki, Kanwarpal Singh
  • Patent number: 11793396
    Abstract: In some embodiments, devices, systems, and methods for advancing and positioning tethered capsule microendoscopes are provided. In some embodiments, a device for capsule endomicroscopy is provided, comprising: a tether having a proximal end and distal end; an optical fiber disposed within the tether; a tube enclosing at least a portion of the tether, the tube having a proximal end and a distal end, a diameter of the tube being larger than the diameter of the tether; a housing coupled to the distal end of the tether and the distal end of the tube; and an optical element disposed within the housing, the optical element being optically coupled to the distal end of the optical fiber and configured to direct light received from the optical fiber toward a periphery of the housing.
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: October 24, 2023
    Assignee: The General Hospital Corporation
    Inventors: Guillermo J. Tearney, Chulho Daryl Hyun, Joseph A. Gardecki
  • Patent number: 11633104
    Abstract: Exemplary embodiments of systems and methods can be provided which can generate data associated with at least one portion of a sample. For example, at least one first radiation can be forwarded to the portion through at least one optical arrangement. At least one second radiation can be received from the portion which is based on the first radiation. Based on an interaction between the optical arrangement and the first radiation and/or the second radiation, the optical arrangement can have a first transfer function. Further, it is possible to forward at least one third radiation to the portion through such optical arrangement (or through another optical arrangement), and receive at least one fourth radiation from the portion which is based on the third radiation. Based on an interaction between the optical arrangement (or the other optical arrangement) and the third radiation and/or the fourth radiation, the optical arrangement (or the other optical arrangement) can have a second transfer function.
    Type: Grant
    Filed: September 20, 2019
    Date of Patent: April 25, 2023
    Assignee: The General Hospital Corporation
    Inventors: Guillermo J. Tearney, Brett Eugene Bouma, Joseph A. Gardecki, Linbo Liu
  • Publication number: 20220330881
    Abstract: An apparatus for determining a shape of a luminal sample including: a catheter including a lens, the catheter disposed within a strain-sensing sheath such that the lens rotates and translates; a structural imaging system optically coupled to the catheter; a strain-sensing system optically coupled to the catheter; and a controller coupled to the strain-sensing system and the structural imaging system. The controller determines: a first position of the catheter relative to the luminal sample at a first location within the strain-sensing sheath; a second position of the catheter relative to the luminal sample at a second location within the strain-sensing sheath; a first strain of the strain-sensing sheath at the first location; a second strain of the strain-sensing sheath at the second location; a local curvature of the luminal sample relative to the catheter; a local curvature of the catheter; and a local curvature of the luminal sample.
    Type: Application
    Filed: June 24, 2022
    Publication date: October 20, 2022
    Applicant: The General Hospital Corporation
    Inventors: Guillermo J. Tearney, Joseph A. Gardecki, Kanwarpal Singh
  • Patent number: 11406318
    Abstract: An apparatus for determining a shape of a luminal sample including: a catheter including a lens, the catheter disposed within a strain-sensing sheath such that the lens rotates and translates; a structural imaging system optically coupled to the catheter; a strain-sensing system optically coupled to the catheter; and a controller coupled to the strain-sensing system and the structural imaging system. The controller determines: a first position of the catheter relative to the luminal sample at a first location within the strain-sensing sheath; a second position of the catheter relative to the luminal sample at a second location within the strain-sensing sheath; a first strain of the strain-sensing sheath at the first location; a second strain of the strain-sensing sheath at the second location; a local curvature of the luminal sample relative to the catheter; a local curvature of the catheter; and a local curvature of the luminal sample.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: August 9, 2022
    Assignee: The General Hospital Corporation
    Inventors: Guillermo J. Tearney, Joseph A. Gardecki, Kanwarpal Singh
  • Publication number: 20210177265
    Abstract: Probes, catheters, systems, methods, and ferrofluids are provides for acquiring direct visualization medical images of internal structures. The probes can include a channel, an optical waveguide, and a ferrofluid attractor. The ferrofluid attractor can be configured to magnetically attract the ferrofluid when exiting a distal port of the channel The medical image can be acquired through the ferrofluid, which is excluding blood from the area that the ferrofluid is occupying. The ferrofluid has a lower optical absorbance than blood, so the acquiring the image through the ferrofluid rather than through blood provides improved images.
    Type: Application
    Filed: October 25, 2018
    Publication date: June 17, 2021
    Inventors: Serguei Melnitochouk, Guillermo J. Tearney, Grace E. Baldwin, Joseph A. Gardecki
  • Publication number: 20210161387
    Abstract: Exemplary method and apparatus for diagnosing or characterizing an inflammation within an anatomical structure can be provided. For example, using at least one source arrangement, it is possible to provide at least one first electro-magnetic radiation to the anatomical structure at at least one first wavelength in vivo. With at least one detector arrangement, it is possible to detect at least one second electro-magnetic radiation at at least one second wavelength provided from the anatomical structure. The second radiation can be associated with the first radiation, and the first wavelength can be shorter than the second wavelength. The second radiation can be provided from the anatomical structure due to at least one change in the anatomical structure caused by the inflammation without providing an artificial fluorescence substance.
    Type: Application
    Filed: January 28, 2021
    Publication date: June 3, 2021
    Inventors: Hao Wang, Joseph A. Gardecki, Guillermo J. Tearney
  • Patent number: 10912462
    Abstract: Exemplary method and apparatus for diagnosing or characterizing an inflammation within an anatomical structure can be provided. For example, using at least one source arrangement, it is possible to provide at least one first electro-magnetic radiation to the anatomical structure at least one first wavelength in vivo. With at least one detector arrangement, it is possible to detect at least one second electro-magnetic radiation at least one second wavelength provided from the anatomical structure. The second radiation can be associated with the first radiation, and the first wavelength can be shorter than the second wavelength. The second radiation can be provided from the anatomical structure due to at least one change in the anatomical structure caused by the inflammation without providing an artificial fluorescence substance.
    Type: Grant
    Filed: July 27, 2015
    Date of Patent: February 9, 2021
    Assignee: The General Hospital Corporation
    Inventors: Hao Wang, Joseph A. Gardecki, Guillermo J. Tearney
  • Publication number: 20200345217
    Abstract: In some embodiments, devices, systems, and methods for advancing and positioning tethered capsule microendoscopes are provided. In some embodiments, a device for capsule endomicroscopy is provided, comprising: a tether having a proximal end and distal end; an optical fiber disposed within the tether; a tube enclosing at least a portion of the tether, the tube having a proximal end and a distal end, a diameter of the tube being larger than the diameter of the tether; a housing coupled to the distal end of the tether and the distal end of the tube; and an optical element disposed within the housing, the optical element being optically coupled to the distal end of the optical fiber and configured to direct light received from the optical fiber toward a periphery of the housing.
    Type: Application
    Filed: January 11, 2019
    Publication date: November 5, 2020
    Inventors: Guillermo J. Tearney, Chulho Daryl Hyun, Joseph A. Gardecki
  • Publication number: 20200046227
    Abstract: Exemplary embodiments of systems and methods can be provided which can generate data associated with at least one portion of a sample. For example, at least one first radiation can be forwarded to the portion through at least one optical arrangement. At least one second radiation can be received from the portion which is based on the first radiation. Based on an interaction between the optical arrangement and the first radiation and/or the second radiation, the optical arrangement can have a first transfer function. Further, it is possible to forward at least one third radiation to the portion through such optical arrangement (or through another optical arrangement), and receive at least one fourth radiation from the portion which is based on the third radiation. Based on an interaction between the optical arrangement (or the other optical arrangement) and the third radiation and/or the fourth radiation, the optical arrangement (or the other optical arrangement) can have a second transfer function.
    Type: Application
    Filed: September 20, 2019
    Publication date: February 13, 2020
    Inventors: Guillermo J. Tearney, Brett Eugene Bouma, Joseph A. Gardecki, Linbo Liu