Patents by Inventor Joseph A. Helpern

Joseph A. Helpern has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9965862
    Abstract: Exemplary method, system, and computer-accessible medium can be provided for determining a measure of diffusional kurtosis by receiving data relating to at least one diffusion weighted image, and determining a measure of a diffusional kurtosis as a function of the received data using a closed form solution procedure. In accordance with certain exemplary embodiments of the present disclosure, provided herein are computer-accessible medium, systems and methods for, e.g., imaging in an MRI system, and, more particularly for facilitating estimation of tensors and tensor-derived measures in diffusional kurtosis imaging (DKI). For example, DKI can facilitate a characterization of non-Gaussian diffusion of water molecules in biological tissues. The diffusion and kurtosis tensors parameterizing the DKI model can typically be estimated via unconstrained least squares (LS) methods.
    Type: Grant
    Filed: August 18, 2014
    Date of Patent: May 8, 2018
    Assignee: New York University
    Inventors: Jens Jensen, Joseph Helpern, Ali Tabesh, Els Fieremans
  • Patent number: 9940708
    Abstract: One aspect of the present disclosure relates to a system that can perform double pulsed diffusional kurtosis imaging (DP-DKI). Image data can be received. The image data can be acquired using a double pulsed field gradient (d-PFG) diffusion sequence. A six dimensional (6D) diffusional kurtosis for the image data can be determined. A magnitude of the image data can be determined in terms of the 6D diffusional kurtosis. DP-DKI can isolate the contributions to the d-PFG diffusion sequence, which can represent leading diffusion effects, that cannot be seen from single pulsed field gradient (s-PFG) diffusion sequences.
    Type: Grant
    Filed: February 10, 2015
    Date of Patent: April 10, 2018
    Assignee: MUSC University of South Carolina
    Inventors: Jens Jensen, Sai Kam Hui, Joseph Helpern
  • Patent number: 9478026
    Abstract: One aspect of the present disclosure relates to a system that can determine a kurtosis diffusion orientation distribution function (dODF) that can, for example, be used with diffusional kurtosis imaging fiber tractography (DKI-FT). The system can include a non-transitory memory storing computer-executable instructions and a processor that executes the computer-executable instructions to perform the following operations. Diffusion magnetic resonance imaging (dMRI) data can be received. Based on the dMRI data, a diffusion tensor (DT) and a diffusional kurtosis tensor (DKT) can be determined. A kurtosis dODF can be determined for the dMRI data based on the DT and the DKT. The kurtosis dODF extends a Gaussian approximation of the DT to include non-Gaussian corrections of the DKT.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: October 25, 2016
    Assignee: MUSC Foundation for Research Development
    Inventors: Jens Jensen, Ali Tabesh, Joseph Helpern
  • Patent number: 9295948
    Abstract: Exemplary embodiments of a methodology, procedure, system, method and computer-accessible medium can be provided to obtain particular information relating to at least one transport property of a material containing at least one membrane, and to determine, e.g., a permeability of the membrane of the material and/or a surface area of the membrane of the material, as a function of, e.g., the obtained particular information.
    Type: Grant
    Filed: March 26, 2010
    Date of Patent: March 29, 2016
    Assignee: New York University
    Inventors: Dmitry S. Novikov, Jens Jensen, Joseph A. Helpern, Els Fieremans
  • Publication number: 20150279029
    Abstract: One aspect of the present disclosure relates to a system that can determine a kurtosis diffusion orientation distribution function (dODF) that can, for example, be used with diffusional kurtosis imaging fiber tractography (DKI-FT). The system can include a non-transitory memory storing computer-executable instructions and a processor that executes the computer-executable instructions to perform the following operations. Diffusion magnetic resonance imaging (dMRI) data can be received. Based on the dMRI data, a diffusion tensor (DT) and a diffusional kurtosis tensor (DKT) can be determined. A kurtosis dODF can be determined for the dMRI data based on the DT and the DKT. The kurtosis dODF extends a Gaussian approximation of the DT to include non-Gaussian corrections of the DKT.
    Type: Application
    Filed: March 31, 2015
    Publication date: October 1, 2015
    Inventors: Jens Jensen, Ali Tabesh, Joseph Helpern
  • Publication number: 20150228073
    Abstract: One aspect of the present disclosure relates to a system that can perform double pulsed diffusional kurtosis imaging (DP-DKI). Image data can be received. The image data can be acquired using a double pulsed field gradient (d-PFG) diffusion sequence. A six dimensional (6D) diffusional kurtosis for the image data can be determined. A magnitude of the image data can be determined in terms of the 6D diffusional kurtosis. DP-DKI can isolate the contributions to the d-PFG diffusion sequence, which can represent leading diffusion effects, that cannot be seen from single pulsed field gradient (s-PFG) diffusion sequences.
    Type: Application
    Filed: February 10, 2015
    Publication date: August 13, 2015
    Inventors: Jens Jensen, Sai Kam Hui, Joseph Helpern
  • Publication number: 20150055845
    Abstract: Exemplary method, system, and computer-accessible medium can be provided for determining a measure of diffusional kurtosis by receiving data relating to at least one diffusion weighted image, and determining a measure of a diffusional kurtosis as a function of the received data using a closed form solution procedure. In accordance with certain exemplary embodiments of the present disclosure, provided herein are computer-accessible medium, systems and methods for, e.g., imaging in an MRI system, and, more particularly for facilitating estimation of tensors and tensor-derived measures in diffusional kurtosis imaging (DKI). For example, DKI can facilitate a characterization of non-Gaussian diffusion of water molecules in biological tissues. The diffusion and kurtosis tensors parameterizing the DKI model can typically be estimated via unconstrained least squares (LS) methods.
    Type: Application
    Filed: August 18, 2014
    Publication date: February 26, 2015
    Inventors: Jens Jensen, Joseph Helpern, Ali Tabesh, Els Fieremans
  • Patent number: 8811706
    Abstract: Exemplary method, system, and computer-accessible medium can be provided for determining a measure of diffusional kurtosis by receiving data relating to at least one diffusion weighted image, and determining a measure of a diffusional kurtosis as a function of the received data using a closed form solution procedure. In accordance with certain exemplary embodiments of the present disclosure, provided herein are computer-accessible medium, systems and methods for, e.g., imaging in an MRI system, and, more particularly for facilitating estimation of tensors and tensor-derived measures in diffusional kurtosis imaging (DKI). For example, DKI can facilitate a characterization of non-Gaussian diffusion of water molecules in biological tissues. The diffusion and kurtosis tensors parameterizing the DKI model can typically be estimated via unconstrained least squares (LS) methods.
    Type: Grant
    Filed: February 7, 2011
    Date of Patent: August 19, 2014
    Assignee: New York University
    Inventors: Jens Jensen, Joseph Helpern, Ali Tabesh, Els Fieremans
  • Publication number: 20120095700
    Abstract: Exemplary embodiments of a methodology, procedure, system, method and computer-accessible medium can be provided to obtain particular information relating to at least one transport property of a material containing at least one membrane, and to determine, e.g., a permeability of the membrane of the material and/or a surface area of the membrane of the material, as a function of, e.g., the obtained particular information.
    Type: Application
    Filed: March 26, 2010
    Publication date: April 19, 2012
    Applicant: New York University
    Inventors: Dmitry S. Novikov, Jens Jensen, Joseph A. Helpern, Els Fieremans
  • Publication number: 20120002851
    Abstract: Exemplary method, system, and computer-accessible medium can be provided for determining a measure of diffusional kurtosis by receiving data relating to at least one diffusion weighted image, and determining a measure of a diffusional kurtosis as a function of the received data using a closed form solution procedure. In accordance with certain exemplary embodiments of the present disclosure, provided herein are computer-accessible medium, systems and methods for, e.g., imaging in an MRI system, and, more particularly for facilitating estimation of tensors and tensor-derived measures in diffusional kurtosis imaging (DKI). For example, DKI can facilitate a characterization of non-Gaussian diffusion of water molecules in biological tissues. The diffusion and kurtosis tensors parameterizing the DKI model can typically be estimated via unconstrained least squares (LS) methods.
    Type: Application
    Filed: February 7, 2011
    Publication date: January 5, 2012
    Applicant: New York University
    Inventors: Jens Jensen, Joseph Helpern, Ali Tabesh, Els Fieremans
  • Patent number: 7852078
    Abstract: Methods, systems, software arrangements and storage medium for measuring the magnetic field correlation function (“MFC”), and more particularly, to methods for measuring the magnetic field correlation function utilizing asymmetric spin echoes. Asymmetric Dual Spin Echo Sequences (“ADSE”) and Echo Planar Imaging Asymmetric Dual Spin Echo Sequences (“EPI-ADSE”) may be employed to apply multiple echoes to a sample and acquire data from which the MFC may be determined.
    Type: Grant
    Filed: February 22, 2010
    Date of Patent: December 14, 2010
    Assignee: New York University
    Inventors: Jens Jensen, Joseph A. Helpern, Glyn Johnson, Ramesh Chandra
  • Publication number: 20100207626
    Abstract: Methods, systems, software arrangements and storage medium for measuring the magnetic field correlation function (“MFC”), and more particularly, to methods for measuring the magnetic field correlation function utilizing asymmetric spin echoes. Asymmetric Dual Spin Echo Sequences (“ADSE”) and Echo Planar Imaging Asymmetric Dual Spin Echo Sequences (“EPI-ADSE”) may be employed to apply multiple echoes to a sample and acquire data from which the MFC may be determined.
    Type: Application
    Filed: February 22, 2010
    Publication date: August 19, 2010
    Applicant: New York University
    Inventors: Jens Jensen, Joseph A. Helpern, Glyn Johnson, Ramesh Chandra
  • Patent number: 7667459
    Abstract: Methods, systems, software arrangements and storage medium for measuring the magnetic field correlation function (“MFC”), and more particularly, to methods for measuring the magnetic field correlation function utilizing asymmetric spin echoes. Asymmetric Dual Spin Echo Sequences (“ADSE”) and Echo Planar Imaging Asymmetric Dual Spin Echo Sequences (“EPI-ADSE”) may be employed to apply multiple echoes to a sample and acquire data from which the MFC may be determined.
    Type: Grant
    Filed: July 8, 2004
    Date of Patent: February 23, 2010
    Assignee: New York University
    Inventors: Jens Jensen, Joseph A. Helpern, Glyn Johnson, Ramesh Chandra
  • Patent number: 7486982
    Abstract: An apparatus and method for providing RF shielding for performing nuclear magnetic resonance (“NMR”) procedures, comprising a radio-opaque holder in combination with radio-opaque magnet components to form an RF shield around a patient undergoing an NMR procedure. In embodiments, a radio-opaque holder having a radio-opaque bottom portion and a radio-opaque canopy is adjoined to an NMR magnet having a radio-opaque cryostat and a radio-opaque service end cap to form an RF shield. A patient is placed on a patient support unit located in the holder bottom portion. The patient support unit, including the patient, is then inserted into the cavity of the NMR magnet and a canopy is placed on top of the bottom portion of the holder. An RF shield is thus created comprising the canopy, the bottom portion, the cryostat of the magnet, and an end cap on the service end of the magnet.
    Type: Grant
    Filed: April 19, 2004
    Date of Patent: February 3, 2009
    Assignee: Advanced Veterinary Technologies, Inc.
    Inventors: Craig A. Branch, Joseph A. Helpern
  • Publication number: 20070135704
    Abstract: An apparatus and method for providing RF shielding for performing nuclear magnetic resonance (“NMR”) procedures, comprising a radio-opaque holder in combination with radio-opaque magnet components to form an RF shield around a patient undergoing an NMR procedure. In embodiments, a radio-opaque holder having a radio-opaque bottom portion and a radio-opaque canopy is adjoined to an NMR magnet having a radio-opaque cryostat and a radio-opaque service end cap to form an RF shield. A patient is placed on a patient support unit located in the holder bottom portion. The patient support unit, including the patient, is then inserted into the cavity of the NMR magnet and a canopy is placed on top of the bottom portion of the holder. An RF shield is thus created comprising the canopy, the bottom portion, the cryostat of the magnet, and an end cap on the service end of the magnet.
    Type: Application
    Filed: November 3, 2006
    Publication date: June 14, 2007
    Applicant: Advanced Veterinary Technologies, Inc.
    Inventors: Craig Branch, Joseph Helpern
  • Publication number: 20060160242
    Abstract: Methods, systems, software arrangements and storage medium for measuring the magnetic field correlation function (“MFC”), and more particularly, to methods for measuring the magnetic field correlation function utilizing asymmetric spin echoes. Asymmetric Dual Spin Echo Sequences (“ADSE”) and Echo Planar Imaging Asymmetric Dual Spin Echo Sequences (“EPI-ADSE”) may be employed to apply multiple echoes to a sample and acquire data from which the MFC may be determined.
    Type: Application
    Filed: July 8, 2004
    Publication date: July 20, 2006
    Inventors: Jens Jensen, Joseph Helpern, Glyn Johnson, Ramesh Chandra
  • Patent number: 7071692
    Abstract: An apparatus and method for providing RF shielding for performing nuclear magnetic resonance (“NMR”) procedures, comprising a radio-opaque holder in combination with radio-opaque magnet components to form an RF shield around a patient undergoing an NMR procedure. In embodiments, a radio-opaque holder having a radio-opaque bottom portion and a radio-opaque canopy is adjoined to an NMR magnet having a radio-opaque cryostat and a radio-opaque service end cap to form an RF shield. A patient is placed on a patient support unit located in the holder bottom portion. The patient support unit, including the patient, is then inserted into the cavity of the NMR magnet and a canopy is placed on top of the bottom portion of the holder. An RF shield is thus created comprising the canopy, the bottom portion, the cryostat of the magnet, and an end cap on the service end of the magnet.
    Type: Grant
    Filed: April 19, 2004
    Date of Patent: July 4, 2006
    Assignee: Advanced Veterinary Technologies, Inc.
    Inventors: Craig A. Branch, Joseph A. Helpern
  • Patent number: 6980847
    Abstract: A magnetic resonance imaging (“MRI”) system and method of correcting for the motion of a subject during an MRI scan. The motion of a subject in an MRI scan is corrected by acquiring nuclear magnetic resonance (“NMR”) spectra of an ordered material attached to a subject, wherein there is a dependence on the NMR spectra of the ordered material's orientation in a magnetic field, and determining an orientation of the subject. Correction information is then supplied to a primary spectrometer channel which is used to execute an MRI scan, and an imaging pulse sequence of the MRI scan is adjusted to correct the subject's orientation.
    Type: Grant
    Filed: March 25, 2002
    Date of Patent: December 27, 2005
    Assignee: New York State Department of Mental Hygiene Office of Mental Health
    Inventors: Alexey Peshkovsky, Joseph A. Helpern
  • Publication number: 20050099588
    Abstract: An arrangement adapted for viewing at least one liquid crystal display includes at least one lens provided in a particular orientation so as to at least partially reduce attenuation of a polarized light emitted by the at least one liquid crystal display. Another arrangement adapted for viewing at least one liquid crystal display includes at least one lens, having an upper portion and a lower portion, the upper portion being provided in a first orientation being arranged so as to at least partially reduce a glare from ambient light, the lower portion being provided in a second orientation being arranged so as to at least partially reduce attenuation of a polarized light emitted by the at least one liquid crystal display.
    Type: Application
    Filed: May 21, 2004
    Publication date: May 12, 2005
    Inventors: Joseph Helpern, Jens Jensen, Truman Brown
  • Publication number: 20050027189
    Abstract: An apparatus and method for providing RF shielding for performing nuclear magnetic resonance (“NMR”) procedures, comprising a radio-opaque holder in combination with radio-opaque magnet components to form an RF shield around a patient undergoing an NMR procedure. In embodiments, a radio-opaque holder having a radio-opaque bottom portion and a radio-opaque canopy is adjoined to an NMR magnet having a radio-opaque cryostat and a radio-opaque service end cap to form an RF shield. A patient is placed on a patient support unit located in the holder bottom portion. The patient support unit, including the patient, is then inserted into the cavity of the NMR magnet and a canopy is placed on top of the bottom portion of the holder. An RF shield is thus created comprising the canopy, the bottom portion, the cryostat of the magnet, and an end cap on the service end of the magnet.
    Type: Application
    Filed: April 19, 2004
    Publication date: February 3, 2005
    Applicant: Advanced Veterinary Technologies, Inc.
    Inventors: Craig Branch, Joseph Helpern