Abstract: A liquid concentrate generation system may comprise a manifold having an inlet receptacle including a first piercing member, an outlet receptacle including a second piercing member, and a flow channel connecting the inlet receptacle and outlet receptacle. The system may further comprise a cartridge having an inlet port and an outlet port sealed by a respective first and second cover. The inlet and outlet port may be respectively configured to displace within the inlet receptacle and outlet receptacle from an unspiked position to a spiked position. First and second piercing members may be in communication with the flow channel and spaced apart respectively from the first and second cover in the unspiked position. The first and second piercing members may be isolated from the flow channel and may respectively puncture the first and second cover in the spiked position.

Abstract: The present invention relates to cyclopropylamide compounds that are useful in the treatment of parasitic infestations of fish. The compounds have the formula (I).

Abstract: The present disclosure relates, in general, to improved processes for the preparation of 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)-benzamide, particularly large-scale processes for manufacturing 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)benzamide and intermediates used in such processes.

Abstract: The invention relates to an improved process for synthesizing N,N-dicyclopropyl-4-(1,5-dimethyl-1H-pyrazol-3-ylamino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide of the formula: (I) Compound (I) is currently in clinical trials for the treatment of myeloproliferative disorders, such as polycythaemia vera, thrombocythaemia and primary myelofibrosis.

Abstract: The invention relates to an improved process for synthesizing N,N-dicyclopropyl-4-(1,5-dimethyl-1H-pyrazol-3-ylamino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide of the formula: (I) Compound (I) is currently in clinical trials for the treatment of myeloproliferative disorders, such as polycythaemia vera, thrombocythaemia and primary myelofibrosis.

Abstract: A temperature controlled oven for heat treating materials such as solid state electronic devices in which a housing forms an enclosure and has an opening for receiving a first sub assembly which forms a second enclosure with an aperture confronting the opening in the housing, and a second sub assembly is disposed within the first sub assembly and removable through the aperture of the first sub assembly to permit external cleaning, the second sub assembly having an opening confronting the opening of the housing and forming a closed air circulation path which contains a heater, blower, and filter for the purpose of maintaining the atmosphere in the second sub assembly relatively particle free.

Abstract: Inherent heating of the air in an oven by a high-velocity recirculating blower is used as constant rate thermal energy source. Constant temperature is maintained by varying the rate of blending of source of cooler air with the heated oven air. Automatic control of temperature is provided by a variable vent operated by a thermal expansion bellows, and a second control means is employed to prevent the oven from exceeding an adjustable maximum temperature.

Abstract: Inherent heating of the air in an oven by a high-velocity recirculating blower is used as constant rate thermal energy source. Constant temperature is maintained by varying the rate of blending of source of cooler air with the heated oven air. Automatic control of temperature is provided by a variable vent operated by a thermal expansion bellows. The bellows is slightly responsive to ambient temperature to compensate for variations thereof.