Abstract: The disclosure provides a method for treating a subject afflicted with a tumor derived from a small cell lung cancer (SCLC) having a high tumor mutational burden (TMB) status comprising administering to the subject a monotherapy comprising an anti-PD-1 antibody or a combination therapy comprising an anti-PD-1 antibody and an anti-CTLA-4 antibody. The present disclosure also provides a method for identifying a subject suitable for treatment with an anti-PD-1 antibody or a combination therapy comprising an anti-PD-1 antibody and an anti-CTLA-4 antibody comprising measuring a TMB status of a biological sample of the subject. A high TMB status identifies the patient as suitable for treatment with an anti-PD-1 antibody or antigen-binding portion thereof. The TMB status can be determined by sequencing nucleic acids in the tumor and identifying a genomic alteration, e.g., a somatic nonsynonymous mutation, in the sequenced nucleic acids.

Abstract: A system for halogenating olefinic-based elastomer, the system comprising a first extruder, a first kneader vessel downstream of said first extruder and in fluid communication with said first extruder, a second extruder downstream of said first kneader vessel and in fluid communication with said first kneader vessel, a second kneader vessel downstream of said second extruder and in fluid communication with said second extruder; and a third extruder downstream of said second kneader vessel and in fluid communication with said second kneader vessel.

Abstract: A system for producing a functionalized olefinic-based polymer, the system comprising a polymerization zone for producing an olefinic-based polymer comprising a mixing section, a deliquifying section, and a quenching section, wherein at least one section of the polymerization zone has a defined cross-sectional area that continually decreases from a first end to a second end of said section; a devolatilization zone comprising a kneader or extruder, wherein said devolatilization zone is downstream of said polymerization zone and in fluid communication with said polymerization zone; and a functionalization zone downstream of said devolatilization zone and in fluid communication with said devolatilization zone.

Abstract: The invention relates to a system for energy storage and recovery, comprising: at least one compressed-air tank, at least one pressurized-water tank in communication with the compressed-air tank, at least one turbine in effective communication with the at least one pressurized-water tank, a generator for generating electrical energy, a high-pressure pump for pumping water from a water reservoir into the pressurized-water tank. According to one aspect of the invention, the turbine in effective communication with the at least one pressurized-water tank is a reaction turbine, which is connected in series with a constant pressure turbine in such a manner that a drive shaft of the reaction turbine is connected to a drive shaft of the constant pressure turbine and a drive shaft of the generator, and the constant pressure turbine is arranged between the reaction turbine and the generator, wherein the generator includes an interface for connection to a public power grid.

Abstract: A reactor comprising a first portion having a generally cylindrical housing, an inlet at one end of said first portion housing, the opposed end of said first portion housing being the outlet of said first portion, where said first portion includes a rotatable shaft positioned axially within said housing and including at least two shearing paddles extending radially from said rotatable shaft and a second portion having a generally frustoconical housing having a first end larger than a second end, said first end constituting an inlet to said second portion and coextensive with said opposed end of said first portion housing, and an outlet at said second end, where said second portion includes a rotatable shaft positioned axially within said housing and including at least one generally helical flight extending radially from said rotatable shaft.

Abstract: A system for producing a functionalized olefinic-based polymer, the system comprising a polymerization zone for producing an olefinic-based polymer comprising a mixing section, a deliquifying section, and a quenching section, wherein at least one section of the polymerization zone has a defined cross-sectional area that continually decreases from a first end to a second end of said section; a devolatilization zone comprising a kneader or extruder, wherein said devolatilization zone is downstream of said polymerization zone and in fluid communication with said polymerization zone; and a functionalization zone downstream of said devolatilization zone and in fluid communication with said devolatilization zone.

Abstract: A polymer synthesis system has a polymerization reactor and a deliquifying-quench extruder downstream of and in fluid communication with the polymerization reactor. The polymerization reactor has an inlet and an outlet with a rotatable shaft positioned axially within the reactor. The deliquifying-quench extruder has an inlet and an outlet, with a shaft assembly positioned axially within the extruder. The shaft assembly includes multiple helical flight configurations and multiple processing zones defined by the multiple flight configurations. The processing zones include an extraction-compaction zone, a sealing zone downstream of the extraction-compaction zone, a vent-cooling zone downstream of the sealing zone, a quenching zone downstream of the vent-cooling zone, and a conveying zone downstream of the quenching zone.

Abstract: Systems and methods are disclosed for collecting vehicle data from a vehicle engine computer of a vehicle and a plurality of sensors disposed about the vehicle and generating feedbacks for a driver of the vehicle using at least the vehicle data. The systems and methods additionally provide for receiving user inputs from the driver responding to the feedbacks so that the user inputs are associated with corresponding rule violations that triggered the feedbacks.

Abstract: The invention relates to a system for energy storage and recovery, comprising: at least one compressed-air tank, at least one pressurized-water tank in communication with the compressed-air tank, at least one turbine in effective communication with the at least one pressurized-water tank, a generator for generating electrical energy, a high-pressure pump for pumping water from a water reservoir into the pressurized-water tank. According to one aspect of the invention, the turbine in effective communication with the at least one pressurized-water tank is a reaction turbine, which is connected in series with a constant pressure turbine in such a manner that a drive shaft of the reaction turbine is connected to a drive shaft of the constant pressure turbine and a drive shaft of the generator, and the constant pressure turbine is arranged between the reaction turbine and the generator, wherein the generator includes an interface for connection to a public power grid.

Abstract: A polymer synthesis system has a polymerization reactor and a deliquifying-quench extruder downstream of and in fluid communication with the polymerization reactor. The polymerization reactor has an inlet and an outlet with a rotatable shaft positioned axially within the reactor. The deliquifying-quench extruder has an inlet and an outlet, with a shaft assembly positioned axially within the extruder. The shaft assembly includes multiple helical flight configurations and multiple processing zones defined by the multiple flight configurations. The processing zones include an extraction-compaction zone, a sealing zone downstream of the extraction-compaction zone, a vent-cooling zone downstream of the sealing zone, a quenching zone downstream of the vent-cooling zone, and a conveying zone downstream of the quenching zone.

Abstract: A system for halogenating olefinic-based elastomer, the system comprising a first extruder, a first kneader vessel downstream of said first extruder and in fluid communication with said first extruder, a second extruder downstream of said first kneader vessel and in fluid communication with said first kneader vessel, a second kneader vessel downstream of said second extruder and in fluid communication with said second extruder; and a third extruder downstream of said second kneader vessel and in fluid communication with said second kneader vessel.

Abstract: A reactor comprising a first portion having a generally cylindrical housing, an inlet at one end of said first portion housing, the opposed end of said first portion housing being the outlet of said first portion, where said first portion includes a rotatable shaft positioned axially within said housing and including at least two shearing paddles extending radially from said rotatable shaft and a second portion having a generally frustoconical housing having a first end larger than a second end, said first end constituting an inlet to said second portion and coextensive with said opposed end of said first portion housing, and an outlet at said second end, where said second portion includes a rotatable shaft positioned axially within said housing and including at least one generally helical flight extending radially from said rotatable shaft.

Abstract: Systems and methods are disclosed for collecting vehicle data from a vehicle engine computer of a vehicle and a plurality of sensors disposed about the vehicle and generating feedbacks for a driver of the vehicle using at least the vehicle data. The systems and methods additionally provide for receiving user inputs from the driver responding to the feedbacks so that the user inputs are associated with corresponding rule violations that triggered the feedbacks.

Abstract: Systems and methods are disclosed for collecting vehicle data from a vehicle engine computer of a vehicle and a plurality of sensors disposed about the vehicle and generating feedbacks for a driver of the vehicle using at least the vehicle data. The systems and methods additionally provide for receiving user inputs from the driver responding to the feedbacks so that the user inputs are associated with corresponding rule violations that triggered the feedbacks.

Abstract: Systems and methods are disclosed for collecting vehicle data from a vehicle engine computer of a vehicle and a plurality of sensors disposed about the vehicle and generating feedbacks for a driver of the vehicle using at least the vehicle data. The systems and methods additionally provide for receiving user inputs from the driver responding to the feedbacks so that the user inputs are associated with corresponding rule violations that triggered the feedbacks.

Abstract: A method for maintaining the rotational speed of a crankshaft of an internal combustion engine having a plurality of cylinders each having a spark plug wherein a predetermined amount of delivered fuel is to be combusted at a firing time within each of the plurality of cylinders with each rotation of the camshaft or crankshaft includes the step of operating the internal combustion engine, measuring the rotational speed of the crankshaft, defining an expected engine speed, calculating a speed error as the rotational speed of the crankshaft less the expected engine speed, and changing the predetermined amount of delivered fuel to be combusted in each of the plurality of cylinders to reduce the speed error. The preferred embodiment is implemented in fuzzy logic.

Abstract: A multichannel power distribution system for individually controlling power from a source to a plurality of loads has individual power control devices and at least one logic stage responsive to status signals to impose preselected operational characteristics on the devices. In one embodiment, isolation circuitry is provided between the power control devices and the logic stage. The isolation circuitry then includes a modulator for converting the status signal to a status pulse train of modulated pulse width, and the logic stage includes decoder logic for measuring the pulse width of the status pulse train. In another embodiment, the logic stage is programmable to alter the operational characteristics of the devices in response to external inputs.

Abstract: Biologically active proteins are bound onto an insoluble carrier by reacting such protein in an aqueous phase with a carrier comprising an activated polysaccharide having a hydrophilic graft co-polmyer grafted thereinto.