Patents by Inventor Joseph A. Mangano
Joseph A. Mangano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 7573688Abstract: Protection methods and protection systems, for high current semiconductor devices with diode junctions, that detect the anomalies in the local temperature at small areas of the junction and protect the device from accelerated aging and premature catastrophic damage. In an embodiment of the method of this invention for protecting a high current semiconductor devices with diode junctions, anomalies in the electrical or optical behavior of the junction are detected and, upon detection of the anomalies, power is diverted away from or around the device.Type: GrantFiled: August 20, 2004Date of Patent: August 11, 2009Assignee: Science Research Laboratory, Inc.Inventor: Joseph Mangano
-
Patent number: 7572623Abstract: The present invention involves methods and devices which enable discrete objects having a conducting inner core, surrounded by a dielectric membrane to be selectively inactivated by electric fields via irreversible breakdown of their dielectric membrane. One important application of the invention is in the selection, purification, and/or purging of desired or undesired biological cells from cell suspensions. According to the invention, electric fields can be utilized to selectively inactivate and render non-viable particular subpopulations of cells in a suspension, while not adversely affecting other desired subpopulations. According to the inventive methods, the cells can be selected on the basis of intrinsic or induced differences in a characteristic electroporation threshold, which can depend, for example, on a difference in cell size and/or critical dielectric membrane breakdown voltage.Type: GrantFiled: April 23, 2003Date of Patent: August 11, 2009Inventors: Joseph Mangano, Henry Eppich
-
Patent number: 7495874Abstract: Protection methods and protection systems for semiconductor devices with diode junctions. The protection methods and protection systems detect the anomalies in the behavior of the junction and protect the device from damage.Type: GrantFiled: January 19, 2007Date of Patent: February 24, 2009Assignee: Science Research Laboratory, Inc.Inventor: Joseph Mangano
-
Publication number: 20070273432Abstract: Protection methods and protection systems, for high current semiconductor devices with diode junctions, that detect the anomalies in the local temperature at small areas of the junction and protect the device from accelerated aging and premature catastrophic damage. In an embodiment of the method of this invention for protecting a high current semiconductor devices with diode junctions, anomalies in the electrical or optical behavior of the junction are detected and, upon detection of the anomalies, power is diverted away from or around the device.Type: ApplicationFiled: August 20, 2004Publication date: November 29, 2007Applicant: Science Research Laboratory, Inc.Inventor: Joseph Mangano
-
Publication number: 20070210854Abstract: Protection methods and protection systems for semiconductor devices with diode junctions. The protection methods and protection systems detect the anomalies in the behavior of the junction and protect the device from damage.Type: ApplicationFiled: January 19, 2007Publication date: September 13, 2007Applicant: Science Research Laboratory, Inc.Inventor: Joseph Mangano
-
Publication number: 20070134794Abstract: The present invention, in some embodiments, describes methods for selecting and enriching specific types of stem cells and/or progenitor cells from a sample containing at least two different types of stem cells and/or progenitor cells. In one embodiment, the method involves selecting and enriching cancer stem cells and/or cancer progenitor cells. In other embodiments, the invention involves improved methods for purging cancer cells from autologous or allogenic transplants prior to reinjection into a patient. In other embodiments, the invention describes improved methods to screen for the efficacy of drug candidate for affecting the function and/or viability of a specific type of stem cell or progenitor cell, for example a cancer stem cell. In this context, the inventive method can involve screening the effectiveness of chemotherapeutic agents in completely eliminating all cancer cells (i.e. mature cancer cells and cancer stem/progenitor cells).Type: ApplicationFiled: February 8, 2007Publication date: June 14, 2007Applicant: Science Research Laboraory, Inc.Inventor: Joseph Mangano
-
Patent number: 7180921Abstract: A method and apparatus for driving a laser diode source, such as a laser diode or a laser diode array. The driver controlling current in response to a signal indicative of excessive current or current density. The signal may be derived from the drive current, the voltage across the laser diode source or the impedance of the laser diode source. The circuit may be pulsed using a switch, such as a GCT. The current to generate drive the laser diode source provided by a capacitive or inductive charging circuit.Type: GrantFiled: August 9, 2004Date of Patent: February 20, 2007Assignee: Science Research Laboratory, Inc.Inventors: Joseph A. Mangano, Rodney Petr
-
Patent number: 7002168Abstract: A dense plasma focus radiation source for generating EUV radiation using Lithium vapor and including a coaxially disposed anode and cathode. The invention includes methods and apparatuses for enhancing the efficiency of EUV radiation production, for protecting, cooling and extending the life of the anode and cathode, for protecting and shielding collecting optics from debris and pressure disturbances in the discharge chamber, and for feeding Lithium into the discharge chamber.Type: GrantFiled: May 21, 2003Date of Patent: February 21, 2006Assignee: Cymer, Inc.Inventors: Jonah Jacob, Joseph A. Mangano, James Moran, Alexander Bykanov, Rodney Petr, Mordechai Rokni
-
Publication number: 20050041707Abstract: A method and apparatus for driving a laser diode source, such as a laser diode or a laser diode array. The driver controlling current in response to a signal indicative of excessive current or current density. The signal may be derived from the drive current, the voltage across the laser diode source or the impedance of the laser diode source. The circuit may be pulsed using a switch, such as a GCT. The current to generate drive the laser diode source provided by a capacitive or inductive charging circuit.Type: ApplicationFiled: August 9, 2004Publication date: February 24, 2005Applicant: Science Research Laboratory, Inc.Inventors: Joseph Mangano, Rodney Petr
-
Patent number: 6798797Abstract: A method and apparatus for driving a laser diode source, such as a laser diode or a laser diode array. The driver controlling current in response to a signal indicative of excessive current or current density. The signal may be derived from the drive current, the voltage across the laser diode source or the impedance of the laser diode source. The circuit may be pulsed using a switch, such as a GCT. The current to generate drive the laser diode source provided by a capacitive or inductive charging circuit.Type: GrantFiled: June 7, 2002Date of Patent: September 28, 2004Assignee: Science Research Laboratory, Inc.Inventors: Joseph Mangano, Rodney A. Petr
-
Publication number: 20040071267Abstract: A dense plasma focus radiation source for generating EUV radiation using Lithium vapor and including a coaxially disposed anode and cathode. The invention includes methods and apparatuses for enhancing the efficiency of EUV radiation production, for protecting, cooling and extending the life of the anode and cathode, for protecting and shielding collecting optics from debris and pressure disturbances in the discharge chamber, and for feeding Lithium into the discharge chamber.Type: ApplicationFiled: May 21, 2003Publication date: April 15, 2004Applicant: Science Research Laboratory, Inc.Inventors: Jonah Jacob, Joseph A. Mangano, James Moran, Alexander Bykanov, Rodney Petr, Mordechai Rokni
-
Publication number: 20030199050Abstract: The present invention involves methods and devices which enable discrete objects having a conducting inner core, surrounded by a dielectric membrane to be selectively inactivated by electric fields via irreversible breakdown of their dielectric membrane. One important application of the invention is in the selection, purification, and/or purging of desired or undesired biological cells from cell suspensions. According to the invention, electric fields can be utilized to selectively inactivate and render non-viable particular subpopulations of cells in a suspension, while not adversely affecting other desired subpopulations. According to the inventive methods, the cells can be selected on the basis of intrinsic or induced differences in a characteristic electroporation threshold, which can depend, for example, on a difference in cell size and/or critical dielectric membrane breakdown voltage.Type: ApplicationFiled: April 23, 2003Publication date: October 23, 2003Inventors: Joseph Mangano, Henry Eppich
-
Patent number: 6589786Abstract: The present invention involves methods and devices which enable discrete objects having a conducting inner core, surrounded by a dielectric membrane to be selectively inactivated by electric fields via irreversible breakdown of their dielectric membrane. One important application of the invention is in the selection, purification, and/or purging of desired or undesired biological cells from cell suspensions. According to the invention, electric fields can be utilized to selectively inactivate and render non-viable particular subpopulations of cells in a suspension, while not adversely affecting other desired subpopulations. According to the inventive methods, the cells can be selected on the basis of intrinsic or induced differences in a characteristic electroporation threshold, which can depend, for example, on a difference in cell size and/or critical dielectric membrane breakdown voltage.Type: GrantFiled: January 21, 2000Date of Patent: July 8, 2003Inventors: Joseph A. Mangano, Henry M. Eppich
-
Publication number: 20030119080Abstract: The present invention, in some embodiments, describes methods for selecting and enriching specific types of stem cells and/or progenitor cells from a sample containing at least two different types of stem cells and/or progenitor cells. In one embodiment, the method involves selecting and enriching cancer stem cells and/or cancer progenitor cells. In other embodiments, the invention involves improved methods for purging cancer cells from autologous or allogenic transplants prior to reinjection into a patient. In other embodiments, the invention describes improved methods to screen for the efficacy of drug candidate for affecting the function and/or viability of a specific type of stem cell or progenitor cell, for example a cancer stem cell. In this context, the inventive method can involve screening the effectiveness of chemotherapeutic agents in completely eliminating all cancer cells (i.e. mature cancer cells and cancer stem/progenitor cells).Type: ApplicationFiled: October 15, 2002Publication date: June 26, 2003Inventor: Joseph A. Mangano
-
Publication number: 20030039280Abstract: A method and apparatus for driving a laser diode source, such as a laser diode or a laser diode array. The driver controlling current in response to a signal indicative of excessive current or current density. The signal may be derived from the drive current, the voltage across the laser diode source or the impedance of the laser diode source. The circuit may be pulsed using a switch, such as a GCT. The current to generate drive the laser diode source provided by a capacitive or inductive charging circuit.Type: ApplicationFiled: June 7, 2002Publication date: February 27, 2003Inventors: Joseph Mangano, Rodney A. Petr
-
Patent number: 6043066Abstract: The present invention involves methods and devices which enable discrete objects having a conducting inner core, surrounded by a dielectric membrane to be selectively inactivated by electric fields via irreversible breakdown of their dielectric membrane. One important application of the invention is in the selection, purification, and/or purging of desired or undesired biological cells from cell suspensions. According to the invention, electric fields can be utilized to selectively inactivate and render non-viable particular subpopulations of cells in a suspension, while not adversely affecting other desired subpopulations. According to the inventive methods, the cells can be selected on the basis of intrinsic or induced differences in a characteristic electroporation threshold; which can depend, for example, on a difference in cell size and/or critical dielectric membrane breakdown voltage.Type: GrantFiled: September 4, 1998Date of Patent: March 28, 2000Inventors: Joseph A. Mangano, Henry M. Eppich
-
Patent number: 4825062Abstract: An extendable large aperture phased array mirror system includes a plurality of mirror segments cooperatively configured to receive an incoming electromagnetic beam. In response to signals from a sensor indicative of wavefront distortion in the beam, a control apparatus displaces a plurality of segment actuators to configure the mirror segments to generate an outgoing conjugate phase electromagnetic beam.Type: GrantFiled: October 29, 1987Date of Patent: April 25, 1989Assignee: Kaman Aerospace CorporationInventors: John D. G. Rather, Gregory H. Ames, Edward K. Conklin, Albert J. Lazzarini, Joseph Mangano, Bobby L. Ulich
-
Patent number: 4211983Abstract: Improved electron beam driven gas laser method and apparatus with the achievement of high single pulse energies therefore enabled by establishment of a magnetic field in a direction substantially parallel to the desired direction of electron beam propagation into a gas. The applied magnetic field is made substantially uniform and sized to exceed that of the self induced magnetic field of the current established by the electron beam, alone or in combination with a discharge current (optionally) established in the gas.Type: GrantFiled: May 1, 1978Date of Patent: July 8, 1980Assignee: Avco Everett Research Laboratory, Inc.Inventors: Jack D. Daugherty, Jonah H. Jacob, Joseph A. Mangano
-
Patent number: 4203078Abstract: Apparatus for and method of operating a laser wherein a discharge is produced preferably in a high pressure lasing gaseous mixture comprising at least one suitable first gaseous species capable of providing an excited state which has a finite probability of being ionized and a molecular second gaseous species having a capability for attaching electrons to form negative ions. The gaseous mixture may, for example, comprise argon, neon, helium, xenon, krypton or a metal vapor such as mercury as the first species and, for example, hydrogen iodide, carbon tetrachloride, bromine, iodine or fluorine as the second species. A buffer gas such as, for example, argon, helium or neon may also be used. The discharge is produced by means of an electron beam and an electric field. The discharge resulting from the application of the electric field heats secondary electrons produced by the electron beam to an energy level sufficient to make excited states.Type: GrantFiled: May 6, 1977Date of Patent: May 13, 1980Assignee: Avco Everett Research Laboratory, Inc.Inventors: Jack D. Daugherty, Jonah H. Jacob, Joseph A. Mangano