Patents by Inventor Joseph A. Marcanio
Joseph A. Marcanio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210128036Abstract: Methods and systems for manufacturing a transdermal sampling and analysis device for non-invasively and transdermally obtaining biological samples from a subject and determining levels of analytes of the obtained biological samples are provided. A method of manufacturing the device may improve performance and includes forming channel structures on the lid of the device, thereby making the spacer/channel support structures physically independent and separable from the sensing electrode. Other methods of manufacturing the device may improve performance and include forming at least one of the electrodes on each of the base and the lid, and forming a recessed second spacer layer over the channel support structures, thereby separating the channel support structures and the electrode on the lid to allow a larger area of the electrode to be exposed to the biological sample.Type: ApplicationFiled: December 21, 2020Publication date: May 6, 2021Inventors: Joseph J. VIDALIS, Joseph A. MARCANIO, John Frederick CURRIE, Helena Woodvine SNYDER, Vikas BHATIA
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Patent number: 10898116Abstract: Methods and systems for manufacturing a transdermal sampling and analysis device for non-invasively and transdermally obtaining biological samples from a subject and determining levels of analytes of the obtained biological samples are provided. A method of manufacturing the device may improve performance and includes forming channel structures on the lid of the device, thereby making the spacer/channel support structures physically independent and separable from the sensing electrode. Other methods of manufacturing the device may improve performance and include forming at least one of the electrodes on each of the base and the lid, and forming a recessed second spacer layer over the channel support structures, thereby separating the channel support structures and the electrode on the lid to allow a larger area of the electrode to be exposed to the biological sample.Type: GrantFiled: March 13, 2014Date of Patent: January 26, 2021Assignee: Cambridge Medical Technologies LLCInventors: Joseph J Vidalis, Joseph A Marcanio, John Frederick Currie, Helena Woodvine Snyder, Vikas Bhatia
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Patent number: 9968284Abstract: A system and methods are provided for reducing electrochemical interference in a transdermal sampling and analysis device. A one-step transdermal glucose biosensor may calculate glucose concentrations that are artificially high compared to traditional home blood glucose sensors due to interference, which may be mitigated by forming an anti-interferent barrier layer over a sensing element. The anti-interferent barrier layer may be formed over a sensing layer and may possess a charge type which repels interferent molecules having the same charge type from interacting with the sensing layer disposed below the anti-interferent barrier layer.Type: GrantFiled: November 29, 2012Date of Patent: May 15, 2018Assignee: CLINITECH, LLCInventors: Joseph J Vidalis, Joseph A Marcanio, John Frederick Currie, Sundar Nadarajan, Helena Woodvine
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Patent number: 9877673Abstract: Transdermal sampling and analysis device, method and system are provided for non-invasively and transdermally obtaining biological samples from a subject and determining levels of analytes of the obtained biological samples. The transdermal sampling and analysis device, method and system may cause disruption to the skin cells to create capillary-like channels from which biological samples may flow to the transdermal sampling and analysis device. The transdermal sampling and analysis device, method and system may collect the biological samples in a reservoir where the biological sample may chemically react with a biologically reactive element. A sensor may convert the produced electrons (ions) into measured electrical signals. The converted signals may be measured and the levels of an analyte may be determined based on the measured signals.Type: GrantFiled: November 11, 2011Date of Patent: January 30, 2018Assignee: CLINITECH, LLCInventors: John F. Currie, Joseph A. Marcanio, Joseph J. Vidalis, Sundar B. Nadarajan
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Patent number: 9451913Abstract: Transdermal sampling and analysis device, method and system are provided for non-invasively and transdermally obtaining biological samples from a subject and determining levels of analytes of the obtained biological samples. The transdermal sampling and analysis device, method and system may cause disruption to the skin cells to create capillary-like channels from which biological samples may flow to the transdermal sampling and analysis device. The transdermal sampling and analysis device, method and system may collect the biological samples in a reservoir and transport the biological samples to a sensing chamber. The sensing chamber may contain at least two sensing electrodes coated with a biologically reactive element which reacts with the transported biological sample. The sensing chamber may be configured to mitigate the formation of air bubbles which may impede the transport and distribution of the biological sample across the entirety of the sensing chamber.Type: GrantFiled: September 11, 2012Date of Patent: September 27, 2016Assignee: TOUCHTEK LABS, LLCInventors: John F. Currie, Joseph A. Marcanio, Joseph J. Vidalis
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Publication number: 20140275895Abstract: Methods and systems for manufacturing a transdermal sampling and analysis device for non-invasively and transdermally obtaining biological samples from a subject and determining levels of analytes of the obtained biological samples are provided. A method of manufacturing the device may improve performance and includes forming channel structures on the lid of the device, thereby making the spacer/channel support structures physically independent and separable from the sensing electrode. Other methods of manufacturing the device may improve performance and include forming at least one of the electrodes on each of the base and the lid, and forming a recessed second spacer layer over the channel support structures, thereby separating the channel support structures and the electrode on the lid to allow a larger area of the electrode to be exposed to the biological sample.Type: ApplicationFiled: March 13, 2014Publication date: September 18, 2014Applicant: Flexible Medical Systems LLCInventors: Joseph J. Vidalis, Joseph A. Marcanio, John Frederick Currie, Helena Woodvine Snyder, Vikas Bhatia
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Publication number: 20130123595Abstract: Transdermal sampling and analysis device, method and system are provided for non-invasively and transdermally obtaining biological samples from a subject and determining levels of analytes of the obtained biological samples. The transdermal sampling and analysis device, method and system may cause disruption to the skin cells to create capillary-like channels from which biological samples may flow to the transdermal sampling and analysis device. The transdermal sampling and analysis device, method and system may collect the biological samples in a reservoir and transport the biological samples to a sensing chamber. The sensing chamber may contain at least two sensing electrodes coated with a biologically reactive element which reacts with the transported biological sample. The sensing chamber may be configured to mitigate the formation of air bubbles which may impede the transport and distribution of the biological sample across the entirety of the sensing chamber.Type: ApplicationFiled: September 11, 2012Publication date: May 16, 2013Applicant: Flexible Medical Systems LLCInventors: John F. Currie, Joseph A. Marcanio, Joseph J. Vidalis
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Patent number: 8348503Abstract: A system and method for providing an active array of temperature sensing and cooling elements, including an active heatsink which further includes an active temperature sensing layer, a thermoelectric cooling layer, and a heatsink, which further includes a plurality of cooling channels. The temperature sensing element within the active temperature sensing layer includes a plurality of switching transistors, a linear transistor, a current sense resistor, a thermistor, a voltage sensing bus, a voltage setting bus, a current measurement bus, a measurement switching bus, a sense control bus, a storage capacitor, and a supply voltage, all under the control of a process control computer. The method of using an active array of temperature sensing and cooling elements includes the steps of aligning the shadow mask, depositing the material, detecting a thermal gradient, and controlling the thermoelectric cooling.Type: GrantFiled: June 18, 2007Date of Patent: January 8, 2013Assignee: Advantech Global, Ltd.Inventors: Thomas P. Brody, Paul R. Malmberg, Joseph A. Marcanio
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Publication number: 20120150004Abstract: Transdermal sampling and analysis device, method and system are provided for non-invasively and transdermally obtaining biological samples from a subject and determining levels of analytes of the obtained biological samples. The transdermal sampling and analysis device, method and system may cause disruption to the skin cells to create capillary-like channels from which biological samples may flow to the transdermal sampling and analysis device. The transdermal sampling and analysis device, method and system may collect the biological samples in a reservoir where the biological sample may chemically react with a biologically reactive element. A sensor may convert the produced electrons (ions) into measured electrical signals. The converted signals may be measured and the levels of an analyte may be determined based on the measured signals.Type: ApplicationFiled: November 11, 2011Publication date: June 14, 2012Applicant: Flexible Medical Systems LLCInventors: John F. Currie, Joseph A. Marcanio, Joseph J. Vidalis, Sundar B. Nadarajan
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Patent number: 8112139Abstract: Electrodes providing excellent recording and physical stability. Electrodes that include a plurality of small teeth that possess a novel design shape and orientation are disclosed. The shallow and relatively long teeth preferably run parallel to the rim of the electrode that presses against the patient's skin. When the electrode is twisted onto skin, the teeth penetrate nearly horizontally under the stratum corneum. The electrodes cause minimal discomfort to the patient since the teeth do not extend to the pain fibers which are located in deeper layers of the skin. The electrodes may house a diversity of electronic components to enable numerous experimental and medical implementations. The electrodes may also be used wirelessly without electrode leads. The electrodes may be fabricated using precision photo-chemical etching techniques that are well known in the art. An electrode installation device that preferably employs the electrodes is also disclosed.Type: GrantFiled: February 4, 2008Date of Patent: February 7, 2012Assignee: University of Pittsburgh—of the Commonwealth System of Higher EducationInventors: Mingui Sun, Robert J. Sclabassi, Wei Liang, Joseph Marcanio
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Publication number: 20090311427Abstract: In a system and method of dimensional adjustment or positioning of an aperture mask for depositing a pattern of material on a substrate, an aperture mask is coupled to a frame such that the frame does not block one or more deposition apertures of the aperture mask. An external force applied to the frame causes the frame to move or bend and place the aperture mask in tension or compression thereby adjusting at least one dimension of the aperture mask or a position of at least one deposition aperture.Type: ApplicationFiled: June 12, 2009Publication date: December 17, 2009Applicant: ADVANTECH GLOBAL, LTDInventors: Joseph A. Marcanio, Roger Stewart
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Publication number: 20090151630Abstract: In a method of preparing and using an aperture mask, a temperature of an aperture mask is increased to a first, mounting temperature (T1), whereupon the size of the aperture mask increases according to its coefficient of thermal expansion (CTEam), until at least one dimension thereof is of a first desired extent. The temperature of a frame is also increased to T1, whereupon the size of the frame grows according to its coefficient of thermal expansion (CTEf), which is lower than CTEam. The aperture mask is fixedly mounted to the frame at T1. The frame mounted aperture mask is then used for depositing a material on a substrate at a deposition temperature T2 that is less than T1, whereupon the frame holds the shadow mask in tension with the one dimension at a second desired extent.Type: ApplicationFiled: November 1, 2006Publication date: June 18, 2009Applicant: ADVANTECH GLOBAL, LTD.Inventors: Joseph A. Marcanio, Jeffrey W. Conrad
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Publication number: 20090098309Abstract: In a method of using and cleaning one or more shadow masks of a shadow mask vapor deposition system used to form an electronic device, a substrate is advanced through series connected deposition vacuum vessels. As the substrate advances through each deposition vacuum vessel, material from a material deposition source positioned in the deposition vacuum vessel is deposited on the substrate through a shadow mask positioned therein. The material is also deposited on a surface of the shadow mask that faces the one material deposition source. Following the deposit of material on the surface of the shadow mask in at least one deposition vacuum vessel, a reactive gas is introduced into the deposition vacuum vessel absent the substrate therein. The reactive gas is then ionized to remove the material deposited on the shadow mask.Type: ApplicationFiled: October 13, 2008Publication date: April 16, 2009Applicant: ADVANTECH GLOBAL, LTDInventors: Thomas Peter Brody, Joseph A. Marcanio
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Publication number: 20080262335Abstract: Electrodes providing excellent recording and physical stability. The present invention encompasses electrodes that include a plurality of small teeth that possess a novel design shape and orientation. The shallow and relatively long teeth preferably run parallel to the rim of the electrode that presses against the patient's skin. When the electrode is twisted onto skin, the tiny teeth penetrate the stratum corneum and move nearly horizontally under the stratum corneum, thus anchoring the electrode securely to the skin. The electrodes of the present invention cause minimal discomfort to the patient since the small teeth do not extend to the pain fibers which are located in deeper layers of the skin. The electrodes may house a wide diversity of electronic components to enable numerous experimental and medical implementations. The electrodes the present invention may also be used wirelessly either singularly or as an array so that no electrode leads extend away from the patients body.Type: ApplicationFiled: February 4, 2008Publication date: October 23, 2008Inventors: Mingui Sun, Robert J. Sclabassi, Wei Liang, Joseph Marcanio
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Publication number: 20080190659Abstract: A multi-layer electronic device can be formed to include an insulative substrate (212), a first vapor deposited conductor layer (312) on the insulative substrate (212), a first vapor deposited insulator layer (314) on the first conductor layer (312), the first insulator layer (314) having at least one via hole (316) therein, and a vapor deposited conductive filler (320) in the via hole (316) of the first insulator layer (314). Desirably, the conductive filler (320) is deposited in the via hole (316) of the first insulator layer (314) such that the surface of the conductive filler (320) opposite the first conductor layer (312) is substantially planar with the surface of the first insulator layer (314) opposite the first conductor layer (312).Type: ApplicationFiled: April 16, 2008Publication date: August 14, 2008Applicant: ADVANTECH GLOBAL, LTDInventors: Thomas Peter Brody, Joseph A. Marcanio
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Patent number: 7361585Abstract: A multi-layer electronic device can be formed to include an insulative substrate (212), a first vapor deposited conductor layer (312) on the insulative substrate (212), a first vapor deposited insulator layer (314) on the first conductor layer (312), the first insulator layer (314) having at least one via hole (316) therein, and a vapor deposited conductive filler (320) in the via hole (316) of the first insulator layer (314). Desirably, the conductive filler (320) is deposited in the via hole (316) of the first insulator layer (314) such that the surface of the conductive filler (320) opposite the first conductor layer (312) is substantially planar with the surface of the first insulator layer (314) opposite the first conductor layer (312).Type: GrantFiled: January 27, 2005Date of Patent: April 22, 2008Assignee: Advantech Global, LtdInventors: Thomas P. Brody, Joseph A. Marcanio
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Publication number: 20070235731Abstract: A system and method for providing an active array of temperature sensing and cooling elements, including an active heatsink which further includes an active temperature sensing layer, a thermoelectric cooling layer, and a heatsink, which further includes a plurality of cooling channels. The temperature sensing element within the active temperature sensing layer includes a plurality of switching transistors, a linear transistor, a current sense resistor, a thermistor, a voltage sensing bus, a voltage setting bus, a current measurement bus, a measurement switching bus, a sense control bus, a storage capacitor, and a supply voltage, all under the control of a process control computer. The method of using an active array of temperature sensing and cooling elements includes the steps of aligning the shadow mask, depositing the material, detecting a thermal gradient, and controlling the thermoelectric cooling.Type: ApplicationFiled: June 18, 2007Publication date: October 11, 2007Inventors: Thomas Brody, Paul Malmberg, Joseph Marcanio
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Patent number: 7268431Abstract: In a shadow mask vapor deposition system, a first conductor is vapor deposited on a substrate and an insulator is vapor deposited on the first conductor. A second conductor is then vapor deposited on at least the insulator. The insulator layer is plasma etched either before or after the vapor deposition of the second conductor to define in the insulator layer a via hole through which at least a portion of the first conductor is exposed. An electrical connection is established between the first and second conductors by way of the via hole.Type: GrantFiled: December 30, 2004Date of Patent: September 11, 2007Assignee: Advantech Global, LtdInventors: Thomas P. Brody, Joseph A. Marcanio
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Patent number: 7232694Abstract: A system and method for active array temperature sensing and cooling. The system includes an active temperature sensing layer, a thermoelectric cooling layer and a heatsink layer. The temperature sensing layer is formed of temperature sensing elements that sense the temperature gradient across an unevenly heated region of the active array substrate. The thermoelectric cooling layer controls the temperature gradient sensed by the temperature sensing layer. The heatsink layer includes a plurality of cooling channels for absorbing thermal energy from the unevenly heated region. The system is under the control of a process control computer.Type: GrantFiled: September 28, 2004Date of Patent: June 19, 2007Assignee: Advantech Global, Ltd.Inventors: Thomas P. Brody, Paul R. Malmberg, Joseph A. Marcanio
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Publication number: 20070051311Abstract: Via holes are formed in a continuous inline shadow mask production system by depositing a first conductor layer and subsequently depositing a first insulator layer over a portion of the first conductor layer. The first insulator layer is deposited in a manner to define at least one notch along its edge. The second insulator layer is then deposited on another portion of the first conductor layer in a manner whereupon the second insulator layer slightly overlaps each notch of the first insulator layer, thereby forming the one or more via holes. A conductive filler can optionally be deposited in each via hole. Lastly, a second conductive layer can be deposited over the first insulator layer, the second insulator layer and, if provided, the conductive filler.Type: ApplicationFiled: November 6, 2006Publication date: March 8, 2007Applicant: Advantech Global, LTDInventors: Thomas Brody, Joseph Marcanio, Jeffrey Conrad, Timothy Cowen