Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: Apparatus for protection of the ear and ear canal, and related methods of use and operation. In one embodiment, the apparatus includes a selectively actuated valve which permits a varying or modulated size of aperture to be created by the wearer while the apparatus is in use, so as to accommodate varying functions, such as complete occlusion (e.g., for use in swimming or other acquatic activities such that water can be completely excluded) or partial occlusion (e.g., such that sounds can be heard by the wearer, whether in air or under water). In one implementation, the apparatus is retained within the ear canal of the wearer by virtue of the apparatus' shape and coordination with one or more natural features or contours of the anatomy in the ear region, without having to be inserted more than superficially into the outer portion of the ear canal.

Abstract: A novel maize variety designated X05H206 and seed, plants and plant parts thereof are produced by crossing inbred maize varieties. Methods for producing a maize plant by crossing hybrid maize variety X05H206 with another maize plant are disclosed. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X05H206 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X05H206, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X05H206. This invention further relates to methods for producing maize varieties derived from maize variety X05H206.

Abstract: A novel maize variety designated X95H693 and seed, plants and plant parts thereof are produced by crossing inbred maize varieties. Methods for producing a maize plant by crossing hybrid maize variety X95H693 with another maize plant are disclosed. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X95H693 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X95H693, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X95H693. This invention further relates to methods for producing maize varieties derived from maize variety X95H693.

Abstract: A novel maize variety designated X95H706 and seed, plants and plant parts thereof are produced by crossing inbred maize varieties. Methods for producing a maize plant by crossing hybrid maize variety X95H706 with another maize plant are disclosed. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X95H706 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X95H706, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X95H706. This invention further relates to methods for producing maize varieties derived from maize variety X95H706.

Abstract: A novel maize variety designated X95H682 and seed, plants and plant parts thereof are produced by crossing inbred maize varieties. Methods for producing a maize plant by crossing hybrid maize variety X95H682 with another maize plant are disclosed. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X95H682 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X95H682, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X95H682. This invention further relates to methods for producing maize varieties derived from maize variety X95H682.

Abstract: A novel maize variety designated X90F449 and seed, plants and plant parts thereof are produced by crossing inbred maize varieties. Methods for producing a maize plant by crossing hybrid maize variety X90F449 with another maize plant are disclosed. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X90F449 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X90F449, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X90F449. This invention further relates to methods for producing maize varieties derived from maize variety X90F449.

Abstract: A novel maize variety designated X00F905 and seed, plants and plant parts thereof are produced by crossing inbred maize varieties. Methods for producing a maize plant by crossing hybrid maize variety X00F905 with another maize plant are disclosed. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X00F905 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X00F905, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X00F905. This invention further relates to methods for producing maize varieties derived from maize variety X00F905.

Abstract: A novel maize variety designated X95D033 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X95D033 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X95D033 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X95D033, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X95D033. This invention further relates to methods for producing maize varieties derived from maize variety X95D033.

Abstract: A novel maize variety designated X03F667 and seed, plants and plant parts thereof are produced by crossing inbred maize varieties. Methods for producing a maize plant by crossing hybrid maize variety X03F667 with another maize plant are disclosed. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X03F667 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X03F667, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X03F667. This invention further relates to methods for producing maize varieties derived from maize variety X03F667.

Abstract: A novel maize variety designated X95D040 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X95D040 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X95D040 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X95D040, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X95D040. This invention further relates to methods for producing maize varieties derived from maize variety X95D040.

Abstract: A novel maize variety designated X00D861 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X00D861 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X00D861 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X00D861, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X00D861. This invention further relates to methods for producing maize varieties derived from maize variety X00D861.

Abstract: A novel maize variety designated X00D894 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X00D894 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X00D894 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X00D894, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X00D894. This invention further relates to methods for producing maize varieties derived from maize variety X00D894.

Abstract: A novel maize variety designated X03F667 and seed, plants and plant parts thereof are produced by crossing inbred maize varieties. Methods for producing a maize plant by crossing hybrid maize variety X03F667 with another maize plant are disclosed. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X03F667 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X03F667, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X03F667. This invention further relates to methods for producing maize varieties derived from maize variety X03F667.

Abstract: A novel maize variety designated X95D076 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X95D076 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X95D076 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X95D076, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X95D076. This invention further relates to methods for producing maize varieties derived from maize variety X95D076.

Abstract: A novel maize variety designated X95D041 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X95D041 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X95D041 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X95D041, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X95D041. This invention further relates to methods for producing maize varieties derived from maize variety X95D041.

Abstract: A novel maize variety designated 38V31 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing maize variety 38V31 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into 38V31 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety 38V31, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety 38V31. This invention further relates to methods for producing maize varieties derived from maize variety 38V31.

Abstract: A novel maize variety designated X03C208 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X03C208 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X03C208 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X03C208, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X03C208. This invention further relates to methods for producing maize varieties derived from maize variety X03C208.

Abstract: A novel maize variety designated X95A943 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X95A943 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X95A943 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X95A943, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X95A943. This invention further relates to methods for producing maize varieties derived from maize variety X95A943.

Abstract: A novel maize variety designated X00C169 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X00C169 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X00C169 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X00C169, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X00C169. This invention further relates to methods for producing maize varieties derived from maize variety X00C169.