Abstract: The invention provides methods of treating or preventing bleeding events or over-anticoagulation in a subject in need thereof who is identified as having sensitivity to a vitamin K antagonist such as warfarin by administering to the subject a therapeutically effective amount of an FXa inhibitor, which can be a direct or indirect FXa inhibitor, or a warfarin or VKA alternative drug or compound. The direct FXa inhibitor can be the small molecule edoxaban p-toluenesulfonate monohydrate, edoxaban, or a pharmaceutically acceptable salt and/or hydrate thereof. In aspects, the subject is identified as having one or more genetic polymorphisms in genes CYP2C9 and/or VKORC1 resulting in loss of function, reduction in function, or aberrant function of these genes and/or their protein products, and sensitivity to warfarin.

Abstract: A coupling device may increase the integrity of a pipe joint. The coupling device may include a first pipe encircling device and a second pipe encircling device connected across the pipe joint by a spanning element. The pipe encircling device may be made up of at least two approximately c-shaped segments. The multi-part nature of the pipe encircling devices may facilitate installation of the coupling device at an excavation site.

Abstract: A coupling device may increase the integrity of a pipe joint. The coupling device may include a first pipe encircling device and a second pipe encircling device connected across the pipe joint by a spanning element. The pipe encircling device may be made up of at least two approximately c-shaped segments. The multi-part nature of the pipe encircling devices may facilitate installation of the coupling device at an excavation site.

Abstract: The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a therapeutic protein comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation and analyzing the conjugation using 2D NMR analysis. More specifically, the present invention relates to the aforementioned materials and methods wherein the water soluble polymer contains an active aminooxy group and wherein an oxime or hydrazone linkage is formed between the oxidized carbohydrate moiety and the active aminooxy group on the water soluble polymer, and wherein the conjugation is carried out in the presence of a nucleophilic catalyst.

Abstract: A deck of cards includes a plurality of cards. Each of the cards includes a front face, a rear face and a plurality of corners. At least one of the corners has a first radius of curvature and at least one other of the corners has a second radius of curvature. The second radius of curvature is less than the first radius of curvature. Methods of performing magic tricks with a deck of cards are also provided.

Abstract: In a preferred embodiment, an apparatus, including; telescoping inner and outer members; a release collar circumferentially encircling the outer member; at least one rotatably mounted pawl disposed in the outer member; the at least one rotatably mounted pawl being depressed into at least a first depression formed circumferentially in the inner member by the release collar; and the at least one rotatably mounted pawl being movable between unlocked and locked positions. A vibration damper for the hold open rod is also provided.

Abstract: The invention relates to systems and methods for manufacturing composite parts for aircraft. In one innovative aspect, a system and method for adjusting a location of a center of gravity of an aircraft relative to a center of lift of a wing of the aircraft is disclosed, wherein a modular spar tunnel mold is provided and configured to be detachably fixed at a plurality of selected locations within a main mold for a fuselage portion of the aircraft. In another innovative aspect, a movable detail or mold is used for manufacturing complex composite parts for an aircraft. In yet another innovative aspect, a movable detail is used to fabricate a common feature for a plurality of different parts for one or more aircraft or a family of aircraft of similar design.

Abstract: A steamer and smoker accessory for generating a selected quantity of steam upwardly into a cooking section of a barbecue grill includes a reservoir including a base member and a lid tightly and securely fastened directly thereto. A plurality of rigid exhausts are directly conjoined to the lid and are in fluid communication with the base member such that the steam is directed upwardly. A flexible conduit having opposed end portions is directly connected to a gas supply source and the steam generating mechanism respectively. The accessory further includes a serrated layer for receiving foodstuff thereon during operating conditions and a plurality of smokers. The serrated layer further includes a plurality of oppositely seated support tabs for supporting the smokers. The plurality of smokers have a substantially cylindrical shape and a plurality of apertures spaced about an outer surface and extending along a length thereof.

Abstract: Abstract of the Disclosure A computer system, computer-readable medium and a method for performing activity based cost modeling. A cost object array has dimensions defined by weight arrays each corresponding to facets of the business by which one would assess profitability and efficiency, such as by products and customers. Each element of the weight arrays represents a user-definable classification, such as particular product families or geographic regions, and is assigned an allocation weight. A cost driver array has the same dimensions as the cost object array comprising metrics, such as the quantity sold or dollars of revenue. A weighted allocation factor for each cost object is a normalized function based on the allocation weights for the corresponding elements of each weight array and the cost driver array with in the cost object array.  Activity costs are allocated to a particular cost object in proportion to the weighted allocation factor associated with that cost object.

Abstract: A system and method for adjusting a location of a center of gravity of an aircraft relative to a center of lift of a wing of the aircraft. In one innovative aspect, a modular spar tunnel mold is provided and configured to be detachably fixed at a selected location within a main mold for a fuselage portion of the aircraft.

Abstract: A system and method for adjusting a location of a center of gravity of an aircraft relative to a center of lift of awing of the aircraft. In one innovative aspect, a modular spar tunnel mold is provided and configured to be detachably fixed at a selected location within a main for a fuselage portion of the aircraft.

Abstract: The invention comprises an electrical contact having a body with a crimping section and a base with resilient contact fingers extending forwardly from the base. The base has a tapered cylindrical section. A sleeve is secured over the base and the resilient contact fingers. The sleeve engages the tapered cylindrical section in an interference fit to secure the sleeve thereon.

Abstract: Apparatus for aiding persons in rising or descending between seated and standing positions provides stability to a conventional walker. In a preferred embodiment, an apparatus has a platform portion and two flexible connection members. The platform portion is substantially rigid and includes two parallel rails. At forward end portions of the rails, openings are formed for pivotable attachment therethrough of the connection members. The connection members are also pivotably attached to a forward portion of the walker, so that when a person places his or her weight on the platform portion, the connection members transmit the weight to the walker, thereby stabilizing the walker.

Abstract: A retrofit method for increasing production capacity of an ammonia plant having a front end including in series primary and secondary reformers and a shift converter for reacting a hydrocarbon feed, steam and air to form a make-up syngas stream comprising hydrogen and nitrogen at about design stoichiometry, and a synthesis loop wherein a recycle syngas stream is combined with the make-up gas to form a syngas feed to ammonia converters. The retrofit involves the installation of an air separation unit to supply oxygen and nitrogen streams. The oxygen is used to enrich air supplied to the secondary reformer and increase the hydrogen content of the make-up gas substantially above the design stoichiometry and capacity. The nitrogen stream is supplied to the synthesis loop to obtain a desired hydrogen to nitrogen ratio in the syngas feed to the ammonia converters and compensate for the excess hydrogen in the make-up gas.

Abstract: A low energy process for the production of hydrogen-rich gas which involves the process sequence of primary reforming and secondary reforming includes parallel steam reformers for the primary reforming of the hydrocarbon feed, one portion of the hydrocarbon feed being heated using radiant heat, i.e., a steam reforming furnace, and another portion of the hydrocarbon feed being heated using indirect heat exchange with the effluent from the secondary reforming, i.e., an exchanger-reactor.

Abstract: Shaft position sensing apparatus includes a group of generally parallel vanes extending generally longitudinally of the shaft axis, means for mounting the vanes in that relationship and attaching them to the shaft for rotation with the shaft, a light source providing a beam of light directed transversely of the shaft axis against the vanes, and a light sensor aligned with the light beam and positioned on the opposite side of the shaft axis from the light source for receiving varying amounts of light dependent upon the angular position of the shaft.