Patents by Inventor Joseph A. Zeleznik
Joseph A. Zeleznik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20100215753Abstract: A solid dosage form is provided which includes an active agent and silicified microcrystalline cellulose, the dosage form formed by a) combining a wetted active agent with dry silicified microcrystalline cellulose in a dryer to form agglomerated particles; and b) incorporating the agglomerated particles into the solid dosage form. In certain preferred embodiments, step b comprises combining said silicified microcrystalline cellulose, said active agent, and colloidal silicon dioxide in a dryer. Preferably, the dryer is a spray dryer, and, in certain embodiments, the active agent may be an herbal extract.Type: ApplicationFiled: February 19, 2010Publication date: August 26, 2010Applicant: J. Rettenmaier & Soehne GMBH+ Co. KGInventors: Bob Sherwood, Joseph A. Zeleznik, David Schaible, Wilhelm Berkulin, Karl-Hans Theissing
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Publication number: 20070053978Abstract: A process for preparing dry extracts from a liquid extract and at least one additional substance by a spray-drying process, characterized in that said at least one additional substance is added to the spray-drying process in a dry form during the spray-drying processes.Type: ApplicationFiled: November 7, 2006Publication date: March 8, 2007Inventors: Bob Sherwood, Joseph Zeleznik, David Schaible, Wilheim Barkulin, Karl-Hans Theissing
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Patent number: 7179488Abstract: A process for preparing dry extracts from a liquid extract and at least one additional substance by a spray-drying process, characterized in that said at least one additional substance is added to the spray-drying process in a dry form during the spray-drying processes.Type: GrantFiled: September 27, 2002Date of Patent: February 20, 2007Inventors: Bob Sherwood, Joseph A. Zeleznik, David Schaible, Wilhelm Berkulin, Karl-Hans Theissing
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Publication number: 20070011904Abstract: A process for preparing agglomerated particles comprising a) providing an active agent in a form suitable for spray drying; and b) combining the active agent with dry silicified microcrystalline cellulose in a dryer to form agglomerated particles.Type: ApplicationFiled: July 10, 2006Publication date: January 18, 2007Applicant: J. Rettenmaier & Soehne GmbH + Co. KGInventors: Bob Sherwood, Joseph Zeleznik, David Schaible, Theodore Montalto
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Publication number: 20050196439Abstract: A process for preparing agglomerated particles comprising a) providing an active agent in a form suitable for spray drying; and b) combining the active agent with dry silicified microcrystalline cellulose in a dryer to form agglomerated particles.Type: ApplicationFiled: October 21, 2004Publication date: September 8, 2005Applicant: J. Rettenmaier & Soehne GmbH + Co. KGInventors: Bob Sherwood, Joseph Zeleznik, David Schaible, Theodore Montalto
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Patent number: 6852336Abstract: Direct compressed solid pharmaceutical dosage forms containing: a) from about 40 to about 95% by weight acetaminophen; b) from about 1 to about 60% by weight of a direct compression vehicle comprising microcrystalline cellulose; and c) from about 0.01 to about 4.0% by weight of a pharmaceutically-acceptable lubricant are disclosed. The acetaminophen and direct compression vehicle are combined under high shear conditions which are sufficient to transform acetaminophen and direct compression vehicle into a homogenous granulate without degradation. In preferred aspects of the invention, the lubricant is also combined with the acetaminophen and direct compression vehicle under high shear conditions. Methods of preparing the directly compressed solid pharmaceutical dosage forms and methods of treatment with the dosage forms are also disclosed. The methods are particularly well suited for preparing directly compressed dosage forms containing high load (i.e.Type: GrantFiled: April 1, 2002Date of Patent: February 8, 2005Assignee: J. Rettenmaier & Soehne GmbH + Co. KGInventors: Edward A. Hunter, Bob E. Sherwood, Joseph A. Zeleznik
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Publication number: 20040115142Abstract: A composition has a particulate agglomerate of microcrystalline cellulose co-processed with additive materials, such as silicon dioxide, that are in intimate association with each other, the additive materials being integrated with or at least partially coating the microcrystalline cellulose. The additive materials are present in an amount of about 1% to about 99% by weight, based on the weight of the microcrystalline cellulose. When the material is silicon dioxide, the silicon dioxide is present in an amount of about 21% to about 99% by weight. A method of preparing a composition includes forming an aqueous slurry containing a mixture of microcrystalline cellulose in the form of a wet cake and additive materials; and drying the slurry to obtain a composition comprising a plurality of agglomerated particles of microcrystalline cellulose in intimate association with the additive material. In another embodiment, the composition has a particulate agglomerate of pure additive material, such as silicon dioxide.Type: ApplicationFiled: September 5, 2003Publication date: June 17, 2004Applicant: JRS Pharma LPInventors: Bob E. Sherwood, Joseph A. Zeleznik, Michael T. Mallon
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Publication number: 20030206978Abstract: A solid dosage form is provided which includes an active agent and silicified microcrystalline cellulose, the dosage form formed by a) combining a wetted active agent with dry silicified microcrystalline cellulose in a dryer to form agglomerated particles; and b) incorporating the agglomerated particles into the solid dosage form. In certain preferred embodiments, step b comprises combining said silicified microcrystalline cellulose, said active agent, and colloidal silicon dioxide in a dryer. Preferably, the dryer is a spray dryer, and, in certain embodiments, the active agent may be an herbal extract.Type: ApplicationFiled: September 27, 2002Publication date: November 6, 2003Inventors: Bob Sherwood, Joseph A. Zeleznik, David Schaible, Wilhelm Berkulin, Karl-Hans Theissing
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Publication number: 20030203050Abstract: A process for preparing dry extracts from a liquid extract and at least one additional substance by a spray-drying process, characterized in that said at least one additional substance is added to the spray-drying process in a dry form during the spray-drying processes.Type: ApplicationFiled: September 27, 2002Publication date: October 30, 2003Inventors: Bob Sherwood, Joseph A. Zeleznik, David Schaible, Wilhelm Berkulin, Karl-Hans Theissing
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Publication number: 20020197310Abstract: Direct compressed solid pharmaceutical dosage forms containing:Type: ApplicationFiled: April 1, 2002Publication date: December 26, 2002Inventors: Edward A. Hunter, Bob E. Sherwood, Joseph A. Zeleznik
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Patent number: 6391337Abstract: Direct compressed solid pharmaceutical dosage forms containing: a) from about 40 to about 95% by weight acetaminophen; b) from about 1 to about 60% by weight of a direct compression vehicle comprising microcrystalline cellulose; and c) from about 0.01 to about 4.0% by weight of a pharmaceutically-acceptable lubricant are disclosed. The acetaminophen and direct compression vehicle are combined under high shear conditions which are sufficient to transform acetaminophen and direct compression vehicle into a homogenous granulate without degradation. In preferred aspects of the invention, the lubricant is also combined with the acetaminophen and direct compression vehicle under high shear conditions. Methods of preparing the directly compressed solid pharmaceutical dosage forms and methods of treatment with the dosage forms are also disclosed. The methods are particularly well suited for preparing directly compressed dosage forms containing high load (i.e.Type: GrantFiled: March 2, 2001Date of Patent: May 21, 2002Assignee: Edward Mendell Co., Inc.Inventors: Edward A. Hunter, Bob E. Sherwood, Joseph A. Zeleznik
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Publication number: 20010014353Abstract: Direct compressed solid pharmaceutical dosage forms containing:Type: ApplicationFiled: March 2, 2001Publication date: August 16, 2001Inventors: Edward A. Hunter, Bob E. Sherwood, Joseph A. Zeleznik
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Patent number: 6217907Abstract: Direct compressed solid pharmaceutical dosage forms containing: a) from about 40 to about 95% by weight acetaminophen; b) from about 1 to about 60% by weight of a direct compression vehicle comprising microcrystalline cellulose; and c) from about 0.01 to about 4.0% by weight of a pharmaceutically-acceptable lubricant are disclosed. The acetaminophen and direct compression vehicle are combined under high shear conditions which are sufficient to transform acetaminophen and direct compression vehicle into a homogenous granulate without degradation. In preferred aspects of the invention, the lubricant is also combined with the acetaminophen and direct compression vehicle under high shear conditions. Methods of preparing the directly compressed solid pharmaceutical dosage forms and methods of treatment with the dosage forms are also disclosed. The methods are particularly well suited for preparing directly compressed dosage forms containing high load (i.e.Type: GrantFiled: May 13, 1999Date of Patent: April 17, 2001Assignee: Edward Mendell Co., Inc.Inventors: Edward A. Hunter, Bob E. Sherwood, Joseph A. Zeleznik
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Patent number: 5965166Abstract: Direct compressed solid pharmaceutical dosage forms containing:a) from about 40 to about 95% by weight acetaminophen;b) from about 1 to about 60% by weight of a direct compression vehicle comprising microcrystalline cellulose; andc) from about 0.01 to about 4.0% by weight of a pharmaceutically-acceptable lubricant are disclosed. The acetaminophen and direct compression vehicle are combined under high shear conditions which are sufficient to transform acetaminophen and direct compression vehicle into a homogenous granulate without degradation. In preferred aspects of the invention, the lubricant is also combined with the acetaminophen and direct compression vehicle under high shear conditions. Methods of preparing the directly compressed solid pharmaceutical dosage forms and methods of treatment with the dosage forms are also disclosed. The methods are particularly well suited for preparing directly compressed dosage forms containing high load (i.e.Type: GrantFiled: November 5, 1997Date of Patent: October 12, 1999Assignee: Edward Mendell Co., Inc.Inventors: Edward A. Hunter, Joseph A. Zeleznik, Bob E. Sherwood
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Patent number: 5733578Abstract: Direct compressed solid pharmaceutical dosage forms containing:a) from about 40 to about 95% by weight acetaminophen;b) from about 1 to about 60% by weight of a direct compression vehicle comprising microcrystalline cellulose; andc) from about 0.01 to about 4.0% by weight of a pharmaceutically-acceptable lubricant are disclosed. The acetaminophen and direct compression vehicle are combined under high shear conditions which are sufficient to transform acetaminophen and direct compression vehicle into a homogenous granulate without degradation. In preferred aspects of the invention, the lubricant is also combined with the acetaminophen and direct compression vehicle under high shear conditions. Methods of preparing the directly compressed solid pharmaceutical dosage forms and methods of treatment with the dosage forms are also disclosed. The methods are particularly well suited for preparing directly compressed dosage forms containing high load (i.e.Type: GrantFiled: November 15, 1995Date of Patent: March 31, 1998Assignee: Edward Mendell Co., Inc.Inventors: Edward A. Hunter, Bob E. Sherwood, Joseph A. Zeleznik