Patents by Inventor JOSEPH A. ZIELINSKI

JOSEPH A. ZIELINSKI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7915314
    Abstract: The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore, the inventors have discovered that the disodium salts of these delivery agents form solvates with ethanol and hydrates with water. The delivery agents have the formula wherein R1, R2, R3, and R4 are independently hydrogen, halogen, C1-C4 alkyl, or C1-C4 alkoxy; and R5 is a substituted or unsubstituted C2-C16 alkylene, substituted or unsubstituted C2-C16 alkenylene, substituted or unsubstituted C1-C12 alkyl(arylene), or substituted or unsubstituted aryl(C1-C12 alkylene). The hydrates and solvates of present invention also have surprisingly greater efficacy for delivering active agents, such as heparin and calcitonin, than their corresponding monosodium salts and free acids. The present invention provides an alcohol solvate, such as ethanol solvate, of a disodium salt of a delivery agent of the formula above.
    Type: Grant
    Filed: December 18, 2009
    Date of Patent: March 29, 2011
    Assignees: Emisphere Technologies, Inc., Novartis AG
    Inventors: William Elliot Bay, Rajesh K. Agarwal, Kiran Chaudhary, Michael M. Goldberg, JoAnne P. Corvino, Shingai Majura, Moise Azria, Joseph Ault, Simon D. Bateman, Subash Patel, Joseph Sikora, Rebecca F. Yang, Joseph Zielinski
  • Publication number: 20060153920
    Abstract: Pharmaceutical compositions that include a poorly water-soluble therapeutic compound, an aqueous solvent, a nonvolatile cosolvent and a bulking agent. The pharmaceutical compositions can be orally ingested or administered parenterally. The pharmaceutical compositions can further be lyophilized to form a pharmaceutically acceptable cake that can be administered orally, e.g., as a solid oral dosage form; or reconstituted and administered parenterally, e.g. as a single i.v. bolus.
    Type: Application
    Filed: December 20, 2005
    Publication date: July 13, 2006
    Inventors: Ketan Amin, Rose-Marie Dannenfelser, Joseph Zielinski, Barbara Wang
  • Publication number: 20060094787
    Abstract: Provided are compositions comprising aqueous suspensions of 5-methyl-2-(2?-chloro-6?-fluoroanilino)phenylacetic acid suitable for oral administration. Methods for making such compositions and methods for their stabilization are provided.
    Type: Application
    Filed: March 11, 2004
    Publication date: May 4, 2006
    Inventors: Patrick Forenzo, Maha Khaled, Barbara Wang, Joseph Zielinski
  • Publication number: 20060068008
    Abstract: Pharmaceutical compositions that include a poorly water-soluble therapeutic compound, an aqueous solvent, a nonvolatile cosolvent and a bulking agent. The pharmaceutical compositions can be orally ingested or administered parenterally. The pharmaceutical compositions can further be lyophilized to form a pharmaceutically acceptable cake that can be administered orally, e.g., as a solid oral dosage form; or reconstituted and administered parenterally, e.g. as a single i.v. bolus.
    Type: Application
    Filed: September 19, 2005
    Publication date: March 30, 2006
    Inventors: Ketan Amin, Rose-Marie Dannenfelser, Joseph Zielinski, Barbara Wang
  • Patent number: 5780408
    Abstract: A solution for use in removing the double sided adhesive tape from mouldings used on motor vehicles and the like. The solution comprises (a) 60-97% by weight of kerosene, (b) 2-27% by weight of oil of turpentine, (c) 1-10% by weight of an oil based surface active agent selected from the group consisting of castor oil and linseed oil, and 0-3% weight of a perfume.
    Type: Grant
    Filed: May 23, 1996
    Date of Patent: July 14, 1998
    Assignee: MMZ Solutions Pty. Ltd.
    Inventors: Mark John Russell, Michael John Rickhuss, Zygmunt Joseph Zielinski