Patents by Inventor Joseph Albert Monforte

Joseph Albert Monforte has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Primers useful for sizing nucleic acids
    Patent number: 6949633
    Abstract: The present invention provides modified oligonucleotide primers designed to incorporate a cleavable moiety so that a 3? portion of the primer (linked to an extension product) can be released from an upstream 5? portion of the primer. Upon selective cleavage of the cleavable site, primer extension products that contain about five or fewer base pairs of the primer sequence are released, to provide more useful sizing and sequence information per fragment than extension products containing the entire primer.
    Type: Grant
    Filed: August 25, 1998
    Date of Patent: September 27, 2005
    Assignee: Sequenom, Inc.
    Inventors: Joseph Albert Monforte, Christopher Hank Becker, Thomas Andrew Shaler, Daniel Joseph Pollart
  • Methods of screening nucleic acids using mass spectrometry
    Patent number: 6051378
    Abstract: This invention relates to methods for screening nucleic acids for mutations by analyzing nonrandomly fragmented nucleic acids using mass spectrometric techniques and to procedures for improving mass resolution and mass accuracy of these methods of detecting
    Type: Grant
    Filed: March 4, 1997
    Date of Patent: April 18, 2000
    Assignee: GeneTrace Systems Inc.
    Inventors: Joseph Albert Monforte, Thomas Andrew Shaler, Yuping Tan, Christopher Hank Becker
  • Methods of preparing nucleic acids for mass spectrometric analysis
    Patent number: 5965363
    Abstract: This invention relates to methods for screening nucleic acids for polymorphisms by analyzing amplified target nucleic acids using mass spectrometric techniques and to procedures for improving mass resolution and mass accuracy of these methods of detecting polymorphisms.
    Type: Grant
    Filed: December 2, 1996
    Date of Patent: October 12, 1999
    Assignee: GeneTrace Systems Inc.
    Inventors: Joseph Albert Monforte, Thomas Andrew Shaler, Yuping Tan, Christopher Hank Becker
  • Oligonucleotide sizing using cleavable primers
    Patent number: 5830655
    Abstract: The present invention provides modified oligonucleotide primers designed to incorporate a cleavable moiety so that a 3' portion of the primer (linked to an extension product) can be released from an upstream 5' portion of the primer. Upon selective cleavage of the cleavable site, primer extension products that contain about five or fewer base pairs of the primer sequence are released, to provide more useful sizing and sequence information per fragment than extension products containing the entire primer.
    Type: Grant
    Filed: April 26, 1996
    Date of Patent: November 3, 1998
    Assignee: SRI International
    Inventors: Joseph Albert Monforte, Christopher Hank Becker, Thomas Andrew Shaler, Daniel Joseph Pollart
  • Oligonucleotide sizing using immobilized cleavable primers
    Patent number: 5700642
    Abstract: The present invention provides modified oligonucleotide primers that (i) are designed for attachment to a solid support in a manner that does not block the ability to extend the primer from its 3' end, and (ii) incorporate a clearable moiety so that a 3' portion of the primer (linked to an extension product) can be released from an immobilized 5' portion. Upon selective cleavage of the cleavable site, a large portion of the primer fragment remains affixed to the solid support. This enables the release of primer extension products that contain about five or fewer base pairs of the primer sequence, to provide more useful sizing and sequence information per fragment than extension products containing the entire primer.
    Type: Grant
    Filed: May 22, 1995
    Date of Patent: December 23, 1997
    Assignee: SRI International
    Inventors: Joseph Albert Monforte, Christopher Hank Becker, Thomas Andrew Shaler, Daniel Joseph Pollart