Abstract: A system, method, and computer-program product includes obtaining application configuration data; computing, via an execution of a designed experiment, a plurality of application usability tests based on the application configuration data; generating a computer-executable application based at least on the plurality of application usability tests; and deploying the computer-executable application to a target computing environment for execution by one or more users.

Abstract: A system includes a conductive sampling swab including a non-mesh substrate and a thermal desorber including a clamping assembly configured to releasably hold the conductive sampling swab. The clamping assembly is configured to be electrically connected to a voltage or current source, and the thermal desorber is configured to resistively heat the conductive sampling swab to a temperature sufficient to vaporize a sample material disposed on the conductive sampling swab.

Abstract: A computing device receives a request requesting a screening design for an experiment. The device obtains factors for screening. A first factor has a first set of candidate inputs comprising at least two candidate inputs for allowable inputs in the experiment. A second factor has a second set of candidate inputs comprising at least three candidate inputs for allowable inputs in the experiment. The device receives an indication of a run size. The device generates the screening design by assigning, based on the run size, the first factor to a two-level group that only allows at most two allowable inputs for the first factor in the experiment. The device generates the screening design by assigning, based on the initial run size, the second factor to a three-level group that only allows at most three allowable inputs for the second factor in the experiment. The device outputs the screening design.

Abstract: A computing device obtains first and second factors for a nesting design and first and second sets of candidate options for the first and second factors, respectively. The computing device also receives a nesting indication that the second factor is nested within the first factor. The computing device generates the nesting design by portioning the first and second sets of candidate options into respective first and second different sets of groups. Based on the nesting indication, the computing device generates an assignment of groups for a design, and also selects options in the nesting design for the first and second factors based on the assignment of groups. The computing device also generates terms for a computer model for a computer simulation of the nesting design, as well as one or more computer-generated assessments of the nesting design based on the computer simulation.

Abstract: A computing device receives a request requesting a screening design for an experiment. The device obtains, for the screening design, factors for screening in the experiment. A first factor is a categorical factor with a first set of candidate inputs comprising at least three candidate inputs in the experiment. A second factor is a continuous factor with a second set of candidate inputs comprising candidate input options within range(s) for the second factor. The device receives an indication of a run size that is a user-requested quantity of runs for the screening design. The device generates the screening design based on the run size. The device outputs the screening design. The screening design comprises runs of a quantity based on the user-requested quantity of runs for the screening design. The runs comprise the first set of candidate inputs and at least three inputs of the second set of candidate inputs.

Abstract: A shoulder implant system includes a humeral stem implant, a humeral neck implant component, a humeral head implant component, and a glenoid implant. The humeral stem implant has a fin coupled to an exterior surface thereof that is inwardly tapered at an angle relative to vertical. At least a portion of the fin forms a wedge that directly engages and compacts cancellous bone during installation of the humeral stem implant. The humeral neck implant component is configured to be coupled with the humeral stem implant. The humeral head implant component is configured to be coupled to the humeral stem implant via the humeral neck implant component. The glenoid implant has a plurality of peripheral pegs. Each of the peripheral pegs has a plurality of sets of resilient lobes.

Abstract: An apparatus and method are described for intelligently scheduling threads across a plurality of logical processors. For example, one embodiment of a processor comprises: a plurality of cores and power management circuitry to associate a plurality of performance values and a plurality of efficiency values with the plurality of cores. In some implementations, each core is associated with at least one performance value and at least one efficiency value. The performance values and efficiency values are used by a scheduler for scheduling threads on the plurality of cores. Some implementations include dynamic core configuration hardware logic coupled to or integral to the power management circuitry to resolve a plurality of configuration requests into a consolidated request for updating one or more performance values of the plurality of performance values and/or one or more efficiency values of the plurality of efficiency values.

Abstract: Devices, systems and methods for cutting openings in a wellbore tubular by a slot cutting assembly having an anchoring system and a slot cutting tool. The anchoring assembly anchors the slot cutting assembly within the wellbore. The slot cutting tool has an extendable cutting blade that is pushed into the wellbore tubular to cut an opening through the tubular. The slot cutting tool may have an extendable stabilizing arm to stabilize and assist with cutting by the blade. The slot cutting assembly may have azimuth and depth sensors to assist with positioning the tool at a desired position downhole. A surface system may be used to control the position of the slot cutting assembly downhole.

Abstract: Disclosed herein are several embodiments of a negative pressure appliance and methods of using the same in the treatment of wounds. Some embodiments are directed to improved fluidic connectors or suction adapters for connecting to a wound site, for example using softer, kink-free conformable suction adapters.

Abstract: The disclosure provides nanoparticle compositions and methods of making and using the same to deliver a bioactive agent such as a nucleic acid which is a PRR agonist to a subject. Various nanoparticle carriers are described. In some instances, the nanoparticle component may include a hydrophobic core having an inorganic particle, and optionally a membrane having a cationic lipid. Various PRR agonists are described. In some instances, the PRR agonist is a RIG-I agonist or a TLR3 agonist.

Abstract: Various embodiments relate generally to data science and data analysis, computer software and systems, and wired and wireless network communications to provide an interface between repositories of disparate datasets and computing machine-based entities that seek access to the datasets, and, more specifically, to a computing and data storage platform that facilitates consolidation of one or more datasets, whereby a collaborative data layer and associated logic facilitate, for example, efficient access to, and implementation of, collaborative datasets. In some examples, a system may include data ingestion controller configured to format datasets to form a first and a second atomized dataset, the second atomized dataset including the first atomized dataset and one or more other atomized datasets. The system may include a dataset query engine configured to identify a portion of a dataset relevant to a query, and to retrieve query results from at least one of different data repositories.

Abstract: The present invention relates to the stereospecific synthesis of (R)-5-((E)-2-pyrrolidin-3-ylvinyl)pyrimidine, its salt forms, and novel polymorphic forms of these salts.

Abstract: A shoulder implant system includes a humeral stem implant, a humeral neck implant component, a humeral head implant component, and a glenoid implant. The humeral stem implant has a fin coupled to an exterior surface thereof that is inwardly tapered at an angle relative to vertical. At least a portion of the fin forms a wedge that directly engages and compacts cancellous bone during installation of the humeral stem implant. The humeral neck implant component is configured to be coupled with the humeral stem implant. The humeral head implant component is configured to be coupled to the humeral stem implant via the humeral neck implant component. The glenoid implant has a plurality of peripheral pegs. Each of the peripheral pegs has a plurality of sets of resilient lobes.

Abstract: A system, method, and computer-program product includes displaying a plurality of factor-setting user interface (UI) control elements configured to receive an input of characters for specifying a set of design of experiment factors for creating a design of experiment (DOE), displaying a plurality of factor type UI control elements configured to receive input for specifying a factor type of a plurality of factor types, displaying a plurality of dynamic rows of editable UI control elements configured to receive inputs of experimental values for the set of DOE factors, and displaying a composite factor UI control component configured to receive inputs for generating one or more control signals that add or remove one or more DOE factors of the set of DOE factors.

Abstract: A system, method, and computer-program product includes displaying a plurality of factor-setting user interface (UI) control elements configured to receive an input of characters for specifying a set of design of experiment factors for creating a design of experiment (DOE), displaying a plurality of factor type UI control elements configured to receive input for specifying a factor type of a plurality of factor types, displaying a plurality of dynamic rows of editable UI control elements configured to receive inputs of experimental values for the set of DOE factors, and displaying a composite factor UI control component configured to receive inputs for generating one or more control signals that add or remove one or more DOE factors of the set of DOE factors.

Abstract: A vehicle tool rack for storing and accessing various individual equipment elements carried aboard a vehicle comprises a base and a turntable rotatably carried on the base such that the turntable is rotatable relative to the base. A plurality of tool receptacles are carried aboard the turntable, whereby the turntable is adapted to simultaneously receive a plurality of individual equipment elements. A plurality of circumferentially-spaced base magnets are fixedly carried by the base and a plurality of circumferentially-spaced turntable magnets are fixedly carried by the turntable. The base magnets and the turntable magnets remain spaced from one another. The turntable has a plurality of distinct stable rotational positions relative to the base wherein the turntable magnets interact with the base magnets to resist rotation out of the distinct stable rotational positions.

Abstract: A computing device receives a target value for a design quality metric. The target value indicates a desired quality of a design of an experiment and is related to an input parameter by a response curve. The computing device also validates the target value as being in a feasibility range for the design quality metric, and if so, determines a candidate value for the input parameter that yields a calculated value for the design quality metric. To determine the calculated value, the computing device iteratively adjusts the candidate value until the calculated value is within a predetermined tolerance of the target value. The computing device then updates an interactive graph visually representing the calculated value for the design quality metric as a function of the candidate value for the input parameter and outputs a graph visually representing the relationship that exists between the candidate value and the calculated value.

Abstract: In one aspect, the present disclosure is directed to a method of manufacturing a substance having an improved tensile strength for additive manufacturing. The method can include providing raw material having a first tensile strength. The raw material can include a polymer. The method can include providing a filler material. The filler material can include clay, single wall carbon nanotubes, multi-wall carbon nanotubes, or boron nitride. The method can include cavitating, within a hydrodynamic cavitation chamber, the raw material and the filler material to produce a substance having a second tensile strength greater than the first tensile strength.

Abstract: A computing device receives a target value for a design quality metric. The target value indicates a desired quality of a design of an experiment and is related to an input parameter by a response curve. The computing device also validates the target value as being in a feasibility range for the design quality metric, and if so, determines a candidate value for the input parameter that yields a calculated value for the design quality metric. To determine the calculated value, the computing device iteratively adjusts the candidate value until the calculated value is within a predetermined tolerance of the target value. The computing device then updates an interactive graph visually representing the calculated value for the design quality metric as a function of the candidate value for the input parameter and outputs a graph visually representing the relationship that exists between the candidate value and the calculated value.

Abstract: A vehicle tool rack for storing and accessing various individual equipment elements carried aboard a vehicle comprises a base and a turntable rotatably carried on the base such that the turntable is rotatable relative to the base. A plurality of tool receptacles are carried aboard the turntable, whereby the turntable is adapted to simultaneously receive a plurality of individual equipment elements. A plurality of circumferentially-spaced base magnets are fixedly carried by the base and a plurality of circumferentially-spaced turntable magnets are fixedly carried by the turntable. The base magnets and the turntable magnets remain spaced from one another. The turntable has a plurality of distinct stable rotational positions relative to the base wherein the turntable magnets interact with the base magnets to resist rotation out of the distinct stable rotational positions.