Patents by Inventor Joseph Arndt

Joseph Arndt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HETEROCYCLIC COMPOUNDS USEFUL AS PDK1 INHIBITORS
    Publication number: 20230113598
    Abstract: The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.
    Type: Application
    Filed: July 21, 2022
    Publication date: April 13, 2023
    Inventors: Joseph ARNDT, Timothy Chan, Kevin Guckian, Gnanasambandam Kumaravel, Wen-Cheng Lee, Edward Yin-Shiang Lin, Daniel Scott, Lihong Sun, Jermaine Thomas, Kurt Van Vloten, Deping Wang, Lei Zhang, Daniel Erlanson
  • HETEROCYCLIC COMPOUNDS USEFUL AS PDK1 INHIBITORS
    Publication number: 20210070752
    Abstract: The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.
    Type: Application
    Filed: June 18, 2020
    Publication date: March 11, 2021
    Inventors: Joseph ARNDT, Timothy R. CHAN, Kevin GUCKIAN, Gnanasambandam KUMARAVEL, Wen-Cherng LEE, Edward Yin-Shiang LIN, Daniel SCOTT, Lihong SUN, Jermaine THOMAS, Kurt VAN VLOTEN, Deping WANG, Lei ZHANG, Daniel ERLANSON
  • HETEROCYCLIC COMPOUNDS USEFUL AS PDK1 INHIBITORS
    Publication number: 20190119268
    Abstract: The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.
    Type: Application
    Filed: May 23, 2018
    Publication date: April 25, 2019
    Inventors: Joseph ARNDT, Timothy CHAN, Kevin GUCKIAN, Gnanasambandam KUMARAVEL, Wen-Cherng LEE, Edward Yin-Shiang LIN, Daniel SCOTT, Lihong SUN, Jermaine THOMAS, Kurt VAN VLOTEN, Deping WANG, Lei ZHANG, Daniel ERLANSON
  • Heterocyclic compounds useful as PDK1 inhibitors
    Patent number: 10030016
    Abstract: The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.
    Type: Grant
    Filed: December 11, 2015
    Date of Patent: July 24, 2018
    Assignees: Sunesis Pharmaceuticals, Inc., Millenium Pharmaceuticals, Inc.
    Inventors: Joseph Arndt, Timothy Chan, Kevin Guckian, Gnanasambandam Kumaravel, Wen-Cherng Lee, Edward Yin-Shiang Lin, Daniel Scott, Lihong Sun, Jermaine Thomas, Kurt van Vloten, Deping Wang, Lei Zhang, Daniel Erlanson
  • JCV neutralizing antibodies
    Patent number: 9567392
    Abstract: In one aspect, the disclosure provides neutralizing antibodies against JCV and methods for the treatment of PML. In some embodiments, aspects of the invention relate to an isolated JC-vims neutralizing monoclonal antibody against JCV capsid protein VPI (JCV-VP1). In some embodiments, the antibody suppresses infectivity of the JC-vims. In some embodiments, the antibody binds the sialic acid binding pocket of JCV-VP1.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: February 14, 2017
    Assignee: Biogen MA Inc.
    Inventors: Kenneth Simon, Thomas Cameron, Deping Wang, Joseph Arndt, Mia Rushe, Justin Caravella, Eric Day
  • Heterocyclic compounds useful as PDK1 inhibitors
    Patent number: 9546165
    Abstract: The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.
    Type: Grant
    Filed: October 5, 2010
    Date of Patent: January 17, 2017
    Assignees: Sunesis Pharmaceuticals, Inc., Millennium Pharmaceuticals, Inc.
    Inventors: Joseph Arndt, Timothy Chan, Kevin Guckian, Gnanasambandam Kumaravel, Wen-Cherng Lee, Edward Yin-Shiang Lin, Daniel Scott, Lihong Sun, Jermaine Thomas, Kurt van Vloten, Deping Wang, Lei Zhang, Daniel Erlanson
  • HETEROCYCLIC COMPOUNDS USEFUL AS PDK1 INHIBITORS
    Publication number: 20160331756
    Abstract: The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.
    Type: Application
    Filed: December 11, 2015
    Publication date: November 17, 2016
    Inventors: Joseph Arndt, Timothy Chan, Kevin Guckian, Gnanasambandam Kumaravel, Wen-Cherng Lee, Edward Yin-Shiang Lin, Daniel Scott, Lihong Sun, Jermaine Thomas, Kurt van Vloten, Deping Wang, Lei Zhang, Daniel Erlanson
  • A METHOD OF REDUCING BRAIN AMYLOID PLAQUES USING ANTI-AB ANTIBODIES
    Publication number: 20150315267
    Abstract: This disclosure relates to the use of anti-A? antibody or antigen-binding fragment thereof to reduce brain amyloid plaques, or minimizes the occurrence of microhemorrhage during chronic dosing of an anti-A? antibody or antigen-binding fragment thereof. For example, the disclosure relates to the method of reducing brain amyloid plaques, comprising administering to a subject an anti-A? antibody or antigen-binding fragment thereof that binds to the same epitope as BIIB037 antibody, wherein the administration can reduce amyloid plaques in brain without affecting vascular amyloid, and wherein BIIB037 antibody binds to an epitope comprising amino acids 3-6 of A?.
    Type: Application
    Filed: December 6, 2013
    Publication date: November 5, 2015
    Inventors: Thierry Bussiere, Paul H. Weinreb, Thomas Engber, Kenneth Rhodes, Joseph Arndt, Fang Qian, Robert W. Dunstan, Shailendra Patel, Jan Grimm, Marcel Maier
  • JCV NEUTRALIZING ANTIBODIES
    Publication number: 20150050271
    Abstract: In one aspect, the disclosure provides neutralizing antibodies against JCV and methods for the treatment of PML. In some embodiments, aspects of the invention relate to an isolated JC-vims neutralizing monoclonal antibody against JCV capsid protein VPI (JCV-VP1). In some embodiments, the antibody suppresses infectivity of the JC-vims. In some embodiments, the antibody binds the sialic acid binding pocket of JCV-VP1.
    Type: Application
    Filed: March 15, 2013
    Publication date: February 19, 2015
    Applicant: Biogen Idec MA Inc.
    Inventors: Kenneth Simon, Thomas Cameron, Deping Wang, Joseph Arndt, Mia Rushe, Justin Caravella, Eric Day
  • HETEROCYCLIC COMPOUNDS USEFUL AS PDK1 INHIBITORS
    Publication number: 20120208819
    Abstract: The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.
    Type: Application
    Filed: October 5, 2010
    Publication date: August 16, 2012
    Inventors: Joseph Arndt, Timothy Chan, Kevin Guckian, Gnanasambandam Kumaravel, Wen-Cherng Lee, Edward Yin-Shiang Lin, Daniel Scott, Lihong Sun, Jermaine Thomas, Kurt van Vloten, Deping Wang, Lei Zhang, Daniel Erlanson
  • ANTI-LYMPHOTOXIN ANTIBODIES
    Publication number: 20120003235
    Abstract: The instant invention is based, at least in part on the identification of a new class of antibodies that result, e.g., in improved LT blocking capabilities. Methods of making the subject binding molecules and methods of using the binding molecules of the invention to antagonize LT?R signaling are also provided.
    Type: Application
    Filed: December 31, 2009
    Publication date: January 5, 2012
    Applicant: BIOGEN IDEC MA INC.
    Inventors: Ann M. Ranger, Ellen Garber, Justin A. Caravella, Alexey A. Lugovskoy, Joseph Arndt, Frederick R. Taylor, Giovanna Antognetti, Eric Day
  • Process for the recovery and purification of a recombinant protein from a cell
    Patent number: 6080844
    Abstract: The present invention involves a process of purifying and recovering a recombinant protein from a suspension of cells. The process of the present invention involves extracting a recombinant protein from a concentrated suspension of cells using a water-miscible organic solvent, isolating the recombinant protein from the suspension of cells, concentrating the recombinant protein to remove the water-miscible organic solvent, precipitating the recombinant protein using an acid, washing the recombinant protein with the salt or free form of a suitable organic acid and recovering the recombinant protein.
    Type: Grant
    Filed: April 23, 1998
    Date of Patent: June 27, 2000
    Assignee: Abbott Laboratories
    Inventors: Ronald E. Carney, Joseph Arndt, Julie R. List, Ellen Marie Schwartz
  • Method of obtaining water-free 2-trimethylammoniumethyl methacrylate chloride (TMAC) from an aqueous solution
    Patent number: 5849946
    Abstract: The invention relates to a method of obtaining water-free 2-trimethylammoniumethyl methacrylate chloride (TMAC) characterized in that an aqueous TMAC solution is subjected to the following operations:(a) Azeotropic removal using an alkyl (meth)acrylate; and(b) Filtration of the resulting suspension.
    Type: Grant
    Filed: May 16, 1997
    Date of Patent: December 15, 1998
    Assignee: Roehm GmbH Chemische Fabrik
    Inventors: Peter-Joseph Arndt, Werner Ude, Klaus Gottmann, Thomas Kehr