Patents by Inventor Joseph Arukwe

Joseph Arukwe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diagnostic imaging agents with MMP inhibitory activity
    Patent number: 8231858
    Abstract: The present invention relates to the field of diagnostic imaging. Specifically, the invention relates to the diagnostic imaging of diseases where specific matrix metalloproteinases are known to be involved. One embodiment of the invention is a compound having matrix metalloproteinase inhibitory activity suitable for diagnostic imaging. Also disclosed in the present invention is a pharmaceutical composition comprising the diagnostic imaging agent of the invention in a form suitable for mammalian administration. The invention furthermore discloses intermediates in the synthesis of the diagnostic imaging agents of the invention and kits for the preparation of the pharmaceutical composition of the invention. The pharmaceutical composition of the invention may be used in the diagnosis of diseases where specific matrix metalloproteinases are known to be involved.
    Type: Grant
    Filed: February 10, 2004
    Date of Patent: July 31, 2012
    Assignee: GE Healthcare Limited
    Inventors: Anthony Storey, Julie Davis, Sally-Ann Ricketts, Marivi Mendizabal, Alan Cuthbertson, Joseph Arukwe, Kirsty Heywood, Ian Wilson, Duncan Wynn, Michael Schafers, Bodo Levkau, Stefan Wagner, Hans-Jörg Breyholz, Klaus Kopka
  • Diagnostic imaging agents with mmp inhibitory activity
    Publication number: 20070071670
    Abstract: The present invention relates to the field of diagnostic imaging. Specifically, the invention relates to the diagnostic imaging of diseases where specific matrix metalloproteinases are known to be involved. One embodiment of the invention is a compound having matrix metalloproteinase inhibitory activity suitable for diagnostic imaging. Also disclosed in the present invention is a pharmaceutical composition comprising the diagnostic imaging agent of the invention in a form suitable for mammalian administration. The invention furthermore discloses intermediates in the synthesis of the diagnostic imaging agents of the invention and kits for the preparation of the pharmaceutical composition of the invention. The pharmaceutical composition of the invention may be used in the diagnosis of diseases where specific matrix metalloproteinases are known to be involved.
    Type: Application
    Filed: February 10, 2004
    Publication date: March 29, 2007
    Inventors: Anthony Storey, Julie Davis, Sally-Ann Ricketts, Marivi Medizabal, Alan Cuthbertson, Joseph Arukwe, Kirsty Heywood, Ian Wilson, Duncan Wynn, Michael Schafers, Bodu Levkau, Stefan Wagner, Hans-Jorg Breyholz, Klaus Kopka
  • Radiofluorination methods
    Publication number: 20050142061
    Abstract: The present invention relates to methods and reagents for [18F]-fluorination, particularly of peptides. The resultant 18F-labelled compounds are useful as radiopharmaceuticals, specifically for use in Positron Emission Tomography (PET). Thus, a compound of formula 18F-(Linker)-SH, such as a compound of formula (IV), (V), or (VI): 18F—(CH2CH2O)n—(CH2)m—SH ??(IV) 18F—(CH2)p—SH ??(V) may be reacted with an activated peptide as a means for 18F-labelling.
    Type: Application
    Filed: March 20, 2003
    Publication date: June 30, 2005
    Inventors: Alan Cuthbertson, Magne Solbakken, Joseph Arukwe, Hege Karlsen
  • Surfactants
    Patent number: 5962626
    Abstract: The present invention provides a polyethylene glycol (PEG) ester surfactant comprising at least one polyethylene glycol moiety and at least one fatty acyl moiety characterized in that said moieties are linked by a linkage incorporating a biodegradable methylene diester unit of formula (I)--CO.O.C(R.sup.1)(R.sup.2).O.CO-- (I)where R.sup.1 and R.sup.2 may, for example, each be a hydrogen atom or a monovalent organic group attached through a carbon atom or R.sup.1 and R.sup.2 together may, for example, form a divalent organic group attached through carbon atoms.
    Type: Grant
    Filed: November 25, 1997
    Date of Patent: October 5, 1999
    Assignee: Nycomed Imaging AS
    Inventors: Per Strande, Harald Dugstad, Balin Balinov, Jan Alfheim, Joseph Arukwe