Patents by Inventor Joseph Audie

Joseph Audie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GLP-1 RECEPTOR AGONISTS HAVING IMPROVED PHARMACOLOGICAL AND DRUG DELIVERY PROPERTIES
    Publication number: 20230015478
    Abstract: Disclosed are polypeptides, compositions, and methods useful for activating a glucagon-like peptide-1 (GLP-1) receptor and treating or preventing diseases or disorders at least partially mediated by glucagon-like peptide 1 (GLP-1).
    Type: Application
    Filed: June 14, 2022
    Publication date: January 19, 2023
    Inventors: Tomi K. Sawyer, Joseph Audie, David J. Diller, Valentin Gribkoff, Bradley L. Pentelute, Solimar G. Santiago, Jonathon R. Sawyer, Allison A. Shrier, Jon T. Swanson, Dinara S. Gunasekera
  • Drug Screening Target For Alzheimer's Disease and Method of Screening Potential Drugs
    Publication number: 20140121355
    Abstract: Drug screening targets and method of screening for potential drugs for treatment or amelioration of Alzheimer's Disease are provided.
    Type: Application
    Filed: December 2, 2013
    Publication date: May 1, 2014
    Inventors: JOSEPH AUDIE, Sergei Yarosiavovitch Ponomarev
  • DRUG SCREENING TARGET FOR ALZHEIMER'S DISEASE AND METHOD OF SCREENING POTENTIAL DRUGS
    Publication number: 20120238465
    Abstract: Drug screening targets and method of screening for potential drugs for treatment or amelioration of Alzheimer's Disease are provided.
    Type: Application
    Filed: March 18, 2012
    Publication date: September 20, 2012
    Inventors: JOSEPH AUDIE, SERGEI YAROSLAVOVITCH PONOMAREV
  • Method for estimating protein-protein binding affinities
    Patent number: 7739091
    Abstract: The present invention is directed to a method of predicting the binding affinity between a first molecular entity and a second molecular entity. The method includes (1) calculating the free energy of binding ?Gbind between the first molecular entity and the second molecular entity according to the equation (17): ?Gbind=?0.82?X+/?+0.064?Xc/s?0.6Xsb?0.93Xhb?0.0007Xgap?0.06?Xtor?0.36??(17) where X+/? is the total number of exposed charged groups; Xc/s is the total number of exposed hydrophobic groups; Xsb is the total number of salt bridges; Xhb is the total number of hydrogen bonds; Xgap is the gap volume at the interface of the first molecular entity and the second molecular entity; Xtor is the total number of exposed side chain torsions; and where ? refers to the difference between the bound and unbound states; and (2) evaluating the free energy of binding to predict the binding affinity between the first and second molecular entities.
    Type: Grant
    Filed: March 21, 2007
    Date of Patent: June 15, 2010
    Assignee: The Research Foundation of State University of New York
    Inventor: Joseph Audie
  • Method for estimating protein-protein binding affinities
    Publication number: 20070224646
    Abstract: The present invention is directed to a method of predicting the binding affinity between a first molecular entity and a second molecular entity, comprising the steps of: (1) calculating the free energy of binding ?Gbind between the first molecular entity and the second molecular entity according to the equation (17): ?Gbind=?0.82?X+/?+0.064?Xc/s?0.6Xsb?0.93Xhb?0.0007Xgap?0.06?Xtor?0.36 ??(17) wherein X+/? is the total number of exposed charged groups; Xc/s is the total number of exposed hydrophobic groups; Xsb is the total number of salt bridges; Xhb is the total number of hydrogen bonds; Xgap is the gap volume at the interface of the first molecular entity and the second molecular entity; Xtor is the total number of exposed side chain torsions; wherein ? refers to the difference between the bound and unbound states; and (2) evaluating the free energy of binding to predict the binding affinity between the first molecular entity and the second molecular entity.
    Type: Application
    Filed: March 21, 2007
    Publication date: September 27, 2007
    Inventor: Joseph Audie