Patents by Inventor Joseph B. Long

Joseph B. Long has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DIAGNOSIS AND TREATMENT OF TAUOPATHY AND CHRONIC TRAUMATIC ENCEPHALOPATHY
    Publication number: 20170030930
    Abstract: A method of diagnosing TBI-induced tauopathy/chronic traumatic encephalopathy (CTE) by obtaining control samples from a control patients that have not been exposed to TBI and recording a normal range of tissue non-specific alkaline phosphatase (TNAP) or total alkaline phosphatase (AP) activity. Then obtaining samples from object patients that have been exposed to TBI. Comparing the biomarker, TNAP/AP, levels of said object patients to the controls. Then determining if the object patient has been exposed to TBI if the TNAP/AP levels are decreased below the normal range. Treating the patient by increasing the level of TNAP enzyme in the brain to within a normal range or modifying the TNAP enzyme activity so that it regains normal activity.
    Type: Application
    Filed: October 13, 2016
    Publication date: February 2, 2017
    Applicant: The Government of the United States, as represented by the Secretary of the Army
    Inventors: Joseph B. Long, Peethambaran Arun
  • Pharmaceutical composition containing pGLU-GLU-PRO-NH2 and method for treating diseases and injuries to the brain, spinal cord and retina using same
    Patent number: 6815425
    Abstract: A nueroprotectant composition wherein the active ingredient is pGLU-GLU-PRO-NH2 or a combination of pGLU-GLU-PRO-NH2 (EEP) and N-tert-Butyl-&agr;-(2-sulfophenyl)nitrone (SPBN) or other nitrone. A method of treating and preventing diseases and injuries of the brain, spinal cord and retina is also presented by administering the endogenous tripeptide EEP to a subject as a neuroprotectant or by administering EEP in combination with SPBN or other nitrone.
    Type: Grant
    Filed: October 20, 2000
    Date of Patent: November 9, 2004
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: James L. Meyerhoff, Michael L. Koenig, Joseph B. Long
  • Pharmaceutical composition containing pGLU-GLU-PRO-NH2 and method for treating diseases and injuries to the brain, spinal cord and retina using same
    Publication number: 20040214781
    Abstract: A neuroprotectant composition wherein the active ingredient is pGLU-GLU-PRO-NH2 or a combination of pGLU-GLU-PRO-NH2 (EEP) and N-tert-Butyl-&agr;-(2-sulfophenyl)nitrone (SPBN) or other nitrone. A method of treating and preventing diseases and injuries of the brain, spinal cord and retina is also presented by administering the endogenous tripeptide EEP to a subject as a neuroprotectant or by administering EEP in combination with SPBN or other nitrone.
    Type: Application
    Filed: May 21, 2004
    Publication date: October 28, 2004
    Inventors: James L. Meyerhoff, Michael L. Koenig, Joseph B. Long
  • Treatment or prophylaxis of retinal pathology and spinal cord injury
    Patent number: 6159958
    Abstract: Compositions containing 2-(phosphonomethyl)-pentanedioic acid (PMPA) and pha. and .beta. N-acetyl-aspartyl-glutamate (NAAG) are appropriate means for treatment of neuronal tissue injury that may result from such factors as injury, toxicity, hypoxia or ischemia (a frequent cause of hypoxia). Target tissues include the brain, spinal cord and retina.
    Type: Grant
    Filed: August 13, 1998
    Date of Patent: December 12, 2000
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: James M. Meyerhoff, Henry D. Hacker, Joseph B. Long