Abstract: The present application provides tricyclic urea compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

Abstract: An improved technique employs an automated agent inside the network perimeter, which generates and sends data packets to a listener outside the network perimeter. Along these lines, the automated agent generates data packets over a specified range of security parameters including port number, payload format, and communications protocol. The agent attempts to send these data packets across the network boundary through a firewall at an egress or other point of the network. The listener receives the data packets and analyzes the payload content of each received data packet for each value of the security parameters (e.g., port number, file type, and protocol). The listener then sends the results of the analysis to a report generator, which summarizes the analysis for an administrator of the network.

Abstract: An improved technique employs an automated agent inside the network perimeter, which generates and sends data packets to a listener outside the network perimeter. Along these lines, the automated agent generates data packets over a specified range of security parameters including port number, payload format, and communications protocol. The agent attempts to send these data packets across the network boundary through a firewall at an egress or other point of the network. The listener receives the data packets and analyzes the payload content of each received data packet for each value of the security parameters (e.g., port number, file type, and protocol). The listener then sends the results of the analysis to a report generator, which summarizes the analysis for an administrator of the network.

Abstract: The techniques described employ a cooperative organization of network service providers to provide improved distributed network services. The network service providers that are constituent to the cooperative organization represent various perspectives within the overall Internet content distribution network, and may include network owners, telecommunications carriers, network access providers, hosting providers and distribution network owners, the latter being an entity that caches content at a plurality of locations distributed on the network. Aspects include managing content caches by receiving control signals specifying actions related to cached content that is distributed on a network, such as the Internet, and forwarding the control signals through to the caching locations to implement the actions represented by the control signals, thus providing content publishers the capability of refreshing their content regardless of where it is cached.