Patents by Inventor Joseph Barbosa

Joseph Barbosa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Quinazoline and pyrido[2,3-d]pyrimidine inhibitors of phosphodiesterase (PDE) 7
    Patent number: 7022849
    Abstract: Quinazoline and pyrido[2,3-d]pyrimidine phosphodiesterase 7 (PDE 7) inhibitors of the following formula wherein R1, R2, L, Y1, Y2, Y3 and Z are as described herein, are provided which are useful in treating T-cell mediated diseases.
    Type: Grant
    Filed: June 17, 2002
    Date of Patent: April 4, 2006
    Assignee: Bristol-Myers Squibb Co.
    Inventors: William J. Pitts, Joseph Barbosa
  • Novel thiazolopyrazoles and methods of their use
    Publication number: 20050282874
    Abstract: This invention concerns novel thiazolopyrazole compounds and compositions comprising them. Methods of using these compounds for the treatment, prevention and management of various diseases and disorders are also encompassed by the invention.
    Type: Application
    Filed: March 31, 2005
    Publication date: December 22, 2005
    Inventors: Joseph Barbosa, Cynthia Fink, Spencer Kimball, Hartmuth Kolb, Zhi-Cai Shi, Ashok Tunoori
  • Purine inhibitors of phosphodiesterase (PDE) 7
    Patent number: 6838559
    Abstract: Purine phosphodiesterase 7 (PDE 7) inhibitors of the following formulas wherein R1, Z, Y and J are described herein, and analogs thereof are provided which are useful in treated T-cell mediated diseases. R2 is defined by the following (a) heteroaryl, or heterocyclo, either of which may be optionally substituted with one to three groups T1, T2, T3; (b) aryl substituted with one to three groups T1, T2, T3 provided that at least one of T1, T2, T3 is other than H; or (c) aryl fused to a heteroaryl or heterocyclo ring wherein the combined ring system may be optionally substituted with one to three groups T1, T2, T3.
    Type: Grant
    Filed: June 17, 2002
    Date of Patent: January 4, 2005
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Wayne Vaccaro, Jacques Y. Roberge, Katerina Leftheris, William J. Pitts, Joseph Barbosa
  • Fused heterocyclic compounds and use thereof
    Publication number: 20040142945
    Abstract: Fused heterocylic compounds of the following Formula 1
    Type: Application
    Filed: November 6, 2003
    Publication date: July 22, 2004
    Inventors: Joseph Barbosa, William J. Pitts, Junqing Guo
  • Spirobarbituric acid derivatives useful as inhibitors of matrix metalloproteases
    Publication number: 20040024001
    Abstract: Compound having the formula (I), 1
    Type: Application
    Filed: April 25, 2003
    Publication date: February 5, 2004
    Inventors: William J. Pitts, Soong-Hoon Kim, Joseph Barbosa, Wayne Vaccaro
  • Barbituric acid derivatives as inhibitors of TNF-alpha converting enzyme (TACE) and/or matrix metalloproteinases
    Publication number: 20030229084
    Abstract: The present application describes novel barbituric acid derivatives of formula I: 1
    Type: Application
    Filed: December 17, 2002
    Publication date: December 11, 2003
    Inventors: Jingwu Duan, Bin Jiang, Lihua Chen, Zhonghui Lu, Joseph Barbosa, William J. Pitts
  • Fused heterocyclic compounds and use thereof
    Publication number: 20030191143
    Abstract: Fused heterocylic compounds of the following Formula 1
    Type: Application
    Filed: November 6, 2002
    Publication date: October 9, 2003
    Inventors: William J. Pitts, Joseph Barbosa, Junqing Guo
  • Pyrimidine inhibitors of phosphodiesterase (PDE) 7
    Publication number: 20030162802
    Abstract: Pyrimidine phosphodiesterase 7 (PDE 7) inhibitors of the following formula 1
    Type: Application
    Filed: June 17, 2002
    Publication date: August 28, 2003
    Inventors: Junqing Guo, Joseph Barbosa, William John Pitts, Marianne Carlsen, Claude Quesnelle, Marco Dodier
  • Purine inhibitors of phosphodiesterase (PDE)
    Publication number: 20030100571
    Abstract: Purine phosphodiesterase 7 (PDE 7) inhibitors of the following formulas 1
    Type: Application
    Filed: June 17, 2002
    Publication date: May 29, 2003
    Inventors: Wayne Vaccaro, Jacques Y. Roberge, Katerina Leftheris, William J. Pitts, Joseph Barbosa
  • Quinazoline and pyrido[2,3-d]pyrimidine inhibitors of phosphodiesterase (PDE) 7
    Publication number: 20030092721
    Abstract: Quinazoline and pyrido[2,3-d]pyrimidine phosphodiesterase 7 (PDE 7) inhibitors of the following formula 1
    Type: Application
    Filed: June 17, 2002
    Publication date: May 15, 2003
    Inventors: William J. Pitts, Joseph Barbosa
  • Fused heterocyclic inhibitors of phosphodiesterase (PDE) 7
    Publication number: 20030092908
    Abstract: Fused heterocylic phosphodiesterase 7 (PDE 7) inhibitors of the following formula 1
    Type: Application
    Filed: May 1, 2002
    Publication date: May 15, 2003
    Inventors: William J. Pitts, Joseph Barbosa, Junqing Guo