Abstract: Disclosed herein are compound embodiments that are useful for treating a variety of diseases, particularly neurological diseases, motor neuron diseases, copper deficiency-related diseases, and/or mitochondrial deficiencies. The compound embodiments described herein also can be used in PET methods. Also disclosed herein are embodiments of methods of making and using the compound embodiments, as well as pharmaceutical formulations comprising the disclosed compound embodiments.

Abstract: Disclosed herein are compound embodiments that are useful for treating a variety of diseases, particularly neurological diseases, motor neuron diseases, copper deficiency-related diseases, and/or mitochondrial deficiencies. The compound embodiments described herein also can be used in PET methods. Also disclosed herein are embodiments of methods of making and using the compound embodiments, as well as pharmaceutical formulations comprising the disclosed compound embodiments.

Abstract: Disclosed herein are compound embodiments that are useful for treating a variety of diseases, particularly neurological diseases, motor neuron diseases, copper deficiency-related diseases, and/or mitochondrial deficiencies. The compound embodiments described herein also can be used in PET methods. Also disclosed herein are embodiments of methods of making and using the compound embodiments, as well as pharmaceutical formulations comprising the disclosed compound embodiments.

Abstract: Certain disclosed embodiments concern a method and an apparatus for determining molecular structure. One embodiment comprises producing sample ions from a sample, cooling molecules of the sample ions by either embedding sample ions in superfluid droplets, such as superfluidic helium droplets, or subjecting sample ions in a cooled ion trap, to a selected temperature approaching absolute zero. Plural cooled sample ions confined in a diffraction zone are oriented using a laser, and a diffraction image is produced from oriented sample ions using an electron beam. Molecular structure is determined using collected images from different orientations obtained under different polarization directions of the orientation laser. Embodiments of an apparatus for determining molecular structure also are disclosed. The apparatus operation, data accumulation and processing are controlled by software.

Abstract: Certain disclosed embodiments concern a method and an apparatus for determining molecular structure. One embodiment comprises producing sample ions from a sample, cooling molecules of the sample ions by either embedding sample ions in superfluid droplets, such as superfluidic helium droplets, or subjecting sample ions in a cooled ion trap, to a selected temperature approaching absolute zero. Plural cooled sample ions confined in a diffraction zone are oriented using a laser, and a diffraction image is produced from oriented sample ions using an electron beam. Molecular structure is determined using collected images from different orientations obtained under different polarization directions of the orientation laser. Embodiments of an apparatus for determining molecular structure also are disclosed. The apparatus operation, data accumulation and processing are controlled by software.

Abstract: The present invention relates to novel methods for combating cell degeneration or dysfunction resulting from neuroinflammatory conditions. The invention especially relates to the use, in the preparation of a medicament for the treatment of neurodegenerative disease associated with neuroinflammation, of an immunogenic compound which is capable of inducing an immune response against a proapoptotic neurotrophin, or an effective amount of a hapten combined with appropriate carriers and/or adjuvants to render the resulting combination capable of inducing an immune response against a proapoptotic neurotrophin. Also disclosed are compositions for the active or passive immunization against neuronal or glial cell apoptosis caused by neuroinflammation as well as methods and means useful for said active or passive immunization.

Abstract: The invention relates to the use of aromatics sulfonamides of the general formula I as peroxynitrite rearrangement catalysts, to the preparation thereof and to the use thereof as medicament for the treatment of various disorders.

Abstract: A string binder is disclosed which is useful for making reinforcing articles for use in the manufacture of molded composite articles. The string binder, in one embodiment, comprises a fibrous carrier substrate material covered with a solidified coating comprising a binder resin material having an acid value of less than about 30 mg KOH/g of resin. Additionally, the coating may include a catalyst applied as a separate layer or in combination with the binder resin material. The string binder may be co-roved with one or more ends of a separate fibrous reinforcing material to make a product suitable for use in various molding applications.

Abstract: A string binder is disclosed which is useful for making reinforcing articles for use in the manufacture of molded composite articles. The string binder, in one embodiment, comprises a fibrous carrier substrate material covered with a solidified coating comprising a binder resin material having an acid value of less than about 30 mg KOH/g of resin. Additionally, the coating may include a catalyst applied as a separate layer or in combination with the binder resin material. The string binder may be co-roved with one or more ends of a separate fibrous reinforcing material to make a product suitable for use in various molding applications.

Abstract: A string binder is disclosed which is useful for making reinforcing articles for use in the manufacture of molded composite articles. The string binder, in one embodiment, includes a fibrous carrier substrate material covered with a solidified coating comprising a binder resin material having an acid value of less than about 30 mg KOH/g of resin. Additionally, the coating may include a catalyst applied as a separate layer or in combination with the binder resin material. The string binder may be co-roved with one or more ends of a separate fibrous reinforcing material to make a product suitable for use in various molding applications.

Abstract: A process and apparatus are provided for forming filament wound composite workpieces. The process comprises the steps of: providing reinforcement material; providing an injection die; providing a winding apparatus including a rotatable mandrel; passing the reinforcement material through the injection die; injecting a resin material into the injection die to impregnate the reinforcement material with the resin material to form impregnated reinforcement material; and winding the impregnated reinforcement material about the mandrel so as to form a composite workpiece.

Abstract: Paint compositions suitable for forming decals which can be applied to vehicle tire sidewalls. The compositions comprise a saturated elastomer having a glass transition temperature not higher than -40 degrees C., a pigment which is preferably titanium dioxide in an amount in the range of 0.5 to 10 times the weight of elastomer, and a solvent. Compositions of this invention are resistant to ultraviolet light and ozone, maintain color and integrity during outdoor aging, and have a long fatigue life.

Abstract: Char obtained by the destructive distillation of scrap rubber vulcanizate is ground in a fluid-energy mill. The resulting black powder, with or without coating with oil, is used as a reinforcing agent for vulcanized rubbers.