Patents by Inventor Joseph Beene BOLEN

Joseph Beene BOLEN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • POLYNUCLEOTIDES ENCODING IMMUNE MODULATING POLYPEPTIDES
    Publication number: 20210269506
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotide molecules encoding at least one polypeptide of interest to modulate the immune response.
    Type: Application
    Filed: September 21, 2020
    Publication date: September 2, 2021
    Inventors: Joseph Beene BOLEN, Joshua P. FREDERICK
  • Polynucleotides encoding immune modulating polypeptides
    Patent number: 10815291
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotide molecules encoding at least one polypeptide of interest to modulate the immune response.
    Type: Grant
    Filed: June 15, 2018
    Date of Patent: October 27, 2020
    Assignee: ModernaTX, Inc.
    Inventors: Joseph Beene Bolen, Joshua P. Frederick
  • POLYNUCLEOTIDES ENCODING LOW DENSITY LIPOPROTEIN RECEPTOR
    Publication number: 20190248864
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotide molecules encoding low density lipoprotein receptor comprising at least one mutation (e.g., an LDLR signally enhancing mutation).
    Type: Application
    Filed: April 30, 2019
    Publication date: August 15, 2019
    Inventors: Jeff Lynn ELLSWORTH, Joseph Beene BOLEN, Francine Marie GREGOIRE, Justin GUILD
  • Polynucleotides encoding low density lipoprotein receptor
    Patent number: 10323076
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotide molecules encoding low density lipoprotein receptor comprising at least one mutation (e.g., an LDLR signally enhancing mutation).
    Type: Grant
    Filed: October 3, 2014
    Date of Patent: June 18, 2019
    Assignee: ModernaTX, Inc.
    Inventors: Jeff Lynn Ellsworth, Joseph Beene Bolen, Francine M. Gregoire, Justin Guild
  • POLYNUCLEOTIDES ENCODING IMMUNE MODULATING POLYPEPTIDES
    Publication number: 20190016781
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotide molecules encoding at least one polypeptide of interest to modulate the immune response.
    Type: Application
    Filed: June 15, 2018
    Publication date: January 17, 2019
    Inventors: Joseph Beene Bolen, Joshua P. Frederick
  • POLYNUCLEOTIDE COMPOSITIONS CONTAINING AMINO ACIDS
    Publication number: 20180214579
    Abstract: The present invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides formulations containing amino acids.
    Type: Application
    Filed: March 26, 2018
    Publication date: August 2, 2018
    Inventors: Örn ALMARSSON, Noubar B. AFEYAN, Joseph Beene BOLEN, Staci SABNIS
  • Polynucleotides encoding immune modulating polypeptides
    Patent number: 10023626
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotide molecules encoding at least one polypeptide of interest to modulate the immune response.
    Type: Grant
    Filed: September 30, 2014
    Date of Patent: July 17, 2018
    Assignee: ModernaTX, Inc.
    Inventors: Joseph Beene Bolen, Joshua P. Frederick
  • Polynucleotide compositions containing amino acids
    Patent number: 9925277
    Abstract: The present invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides formulations containing amino acids.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: March 27, 2018
    Assignee: ModernaTX, Inc.
    Inventors: Örn Almarsson, Noubar B. Afeyan, Joseph Beene Bolen, Staci Sabnis
  • POLYNUCLEOTIDES FOR THE IN VIVO PRODUCTION OF ANTIBODIES
    Publication number: 20170002060
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides encoding an antibody, variant or fragment.
    Type: Application
    Filed: January 8, 2015
    Publication date: January 5, 2017
    Inventors: Joseph Beene Bolen, Axel Bouchon, Giuseppe Ciaramella, Eric Yi-Chun Huang
  • Polynucleotides Encoding Low Density Lipoprotein Receptor
    Publication number: 20160244501
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotide molecules encoding low density lipoprotein receptor comprising at least one mutation (e.g., an LDLR signally enhancing mutation).
    Type: Application
    Filed: October 3, 2014
    Publication date: August 25, 2016
    Applicant: Moderna Therapeutics, Inc.
    Inventors: Jeff Lynn ELLSWORTH, Joseph Beene BOLEN, Francine M. GREGOIRE, Justin GUILD
  • POLYNUCLEOTIDES ENCODING IMMUNE MODULATING POLYPEPTIDES
    Publication number: 20160244502
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotide molecules encoding at least one polypeptide of interest to modulate the immune response.
    Type: Application
    Filed: September 30, 2014
    Publication date: August 25, 2016
    Inventors: Joseph Beene Bolen, Joshua P. Frederick
  • POLYNUCLEOTIDE COMPOSITIONS CONTAINING AMINO ACIDS
    Publication number: 20160243259
    Abstract: The present invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides formulations containing amino acids.
    Type: Application
    Filed: September 12, 2014
    Publication date: August 25, 2016
    Inventors: Örn ALMARSSON, Noubar B. AFEYAN, Joseph Beene BOLEN, Staci SABNIS
  • Compositions and Methods of Altering Cholesterol Levels
    Publication number: 20160136236
    Abstract: The present invention relates to compositions, methods and kits using polynucleotides, primary transcripts and mmRNA molecules. The present invention also relates to compositions and methods for altering cholesterol levels using polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: March 14, 2014
    Publication date: May 19, 2016
    Applicant: Moderna Therapeutics, Inc.
    Inventors: Stephen G. HOGE, Eric Yi-Chun HUANG, Joseph Beene BOLEN, Justin GUILD, Antonin DE FOUGEROLLES, Jeff Lynn ELLSWORTH