Patents by Inventor Joseph Boothe
Joseph Boothe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8597694Abstract: The physical stability of oleosomes is preserved in a composition by introducing a multihydric alcohol and an acid that can reduce the pH of the composition of less than 6. The resultant composition can be useful in the manufacture of cosmetic, food, and pharmaceutical products, among others.Type: GrantFiled: April 10, 2009Date of Patent: December 3, 2013Assignee: Sembiosys Genetics, Inc.Inventors: Jacob Guth, Joseph Boothe, Mitch Beazer, Kent Shafer
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Publication number: 20110081435Abstract: The physical stability of oleosomes is preserved in a composition by introducing a multihydric alcohol and an acid that can reduce the pH of the composition of less than 6. The resultant composition can be useful in the manufacture of cosmetic, food, and pharmaceutical products, among others.Type: ApplicationFiled: April 10, 2009Publication date: April 7, 2011Inventors: Jacob Guth, Joseph Boothe, Mitch Beazer, Kent Shafer
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Publication number: 20090282583Abstract: Commercial production of human insulin can be effected via transgenic expression in plant seeds. Thus, levels of insulin accumulation exceeding 0.1% of total cellular protein can be achieved recombinantly, through expression of the insulin with a single-chain antibody as a fusion partner. Production in seeds offers flexibility in storage and shipment of insulin as a raw material, and insulin retains its activity upon extraction from stored seed. Further, the amount of biomass subjected to extraction is limited, due to the relatively low water content of plant seeds.Type: ApplicationFiled: May 12, 2009Publication date: November 12, 2009Applicant: SEMBIOSYS GENETICS INC.Inventors: MAURICE M. MOLONEY, JOSEPH BOOTHE, RICHARD KEON, CORY NYKIFORUK, GIJS VAN ROOIJEN
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Patent number: 7585645Abstract: The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in a variety of products including food products, personal care products and pharmaceutical products. In a preferred embodiment the emulsions comprise thioredoxin and/or thioredoxin reductase.Type: GrantFiled: July 5, 2001Date of Patent: September 8, 2009Assignee: Sembiosys Genetics Inc.Inventors: Harm M. Deckers, Gijs van Rooijen, Joseph Boothe, Janis Goll, Maurice M. Moloney, Bipin K. Dalmia
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Patent number: 7547821Abstract: Commercial production of human insulin can be affected via transgenic expression in plant seeds. Thus, levels of insulin accumulation exceeding 0.1% of total cellular protein can be achieved recombinantly, through expression of the insulin with a single-chain antibody as a fusion partner. Production in seeds offers flexibility in storage and shipment of insulin as a raw material, and insulin retains its activity upon extraction from stored seed. Further, the amount of biomass subjected to extraction is limited, due to the relatively low water content of plant seeds.Type: GrantFiled: June 17, 2004Date of Patent: June 16, 2009Assignee: SemBioSys Genetics Inc.Inventors: Maurice M. Moloney, Joseph Boothe, Richard Keon, Cory Nykiforuk, Gijs Van Rooijen
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Publication number: 20080184394Abstract: A method for the commercial production of chymosin which involves the recombinant expression of chymosin in plant seeds, that enables chymosin to accumulate to at least 0.5% (w/w) of total seed protein is described. An improved method for the isolation of chymosin from the seed is also described.Type: ApplicationFiled: April 3, 2008Publication date: July 31, 2008Inventors: Gijs van Rooijen, Keon Richard Glenn, Yin Shen, Joseph Boothe
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Patent number: 7390936Abstract: A method for the commercial production of chymosin which involves the recombinant expression of chymosin in plant seeds, that enables chymosin to accumulate to at least 0.5% (w/w) of total seed protein is described. An improved method for the isolation of chymosin from the seed is also described.Type: GrantFiled: August 23, 2000Date of Patent: June 24, 2008Assignee: SemBioSys Genetics Inc.Inventors: Gijs Van Rooijen, Keon Richard Glenn, Yin Shen, Joseph Boothe
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Patent number: 7332587Abstract: A method for the separation of a target molecule from a mixture is described. The method employs oil bodies and their associated proteins as affinity matrices for the selective, non-covalent binding of desired target molecules. The oil body proteins may be genetically fused to a ligand having specificity for the desired target molecule. Native oil body proteins can also be used in conjunction with an oil body protein specific ligand such as an antibody or an oil body binding protein. The method allows the separation and recovery of the desired target molecules due to the difference in densities between oil bodies and aqueous solutions.Type: GrantFiled: October 1, 2002Date of Patent: February 19, 2008Assignee: SemBioSys Genetics Inc.Inventors: Maurice Moloney, Joseph Boothe, Gijs Van Rooijen
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Publication number: 20070196914Abstract: The present invention provides novel emulsions that comprise oil bodies. The invention also relates to novel methods for generating formulations comprising oil bodies and active ingredients wherein the active ingredient is partitioned into the oil body. The methods are particularly useful for generating emulsions with either hydrophobic or amphipathic biologically active agents.Type: ApplicationFiled: October 4, 2004Publication date: August 23, 2007Applicant: SemBioSys Genetics Inc.Inventors: Elizabeth Murray, Joseph Boothe, Nancy-Ann Markley
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Patent number: 6924363Abstract: A method for the separation of a target molecule from a mixture is described. The method employs oil bodies and their associated proteins as affinity matrices for the selective, non-covalent binding of desired target molecules. The oil body proteins may be genetically fused to a ligand having specificity for the desired target molecule. Native oil body proteins can also be used in conjunction with an oil body protein specific ligand such as an antibody or an oil body binding protein. The method allows the separation and recovery of the desired target molecules due to the difference in densities between oil bodies and aqueous solutions.Type: GrantFiled: November 7, 2000Date of Patent: August 2, 2005Assignee: SemBioSys Genetics Inc.Inventors: Maurice Moloney, Joseph Boothe, Gijs van Rooijen
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Publication number: 20050106157Abstract: The present invention provides novel adjuvants which comprise oil bodies. The invention also provides vaccine or immunogenic formulations comprising oil bodies and an antigen and methods for preparing the vaccine or immunogenic formulations and the use of the vaccine or immunogenic formulations to elicit an immune response.Type: ApplicationFiled: January 15, 2004Publication date: May 19, 2005Inventors: Harm Deckers, Gijs Rooijen, Joseph Boothe, Janis Goll, Maurice Moloney, Anthony Schryvers, Joenel Alcantara, Wendy Hutchins
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Publication number: 20050039235Abstract: Methods for the production of insulin in plants are described. In one embodiment, the present invention provides a method for the expression of insulin in plants comprising: (a) providing a chimeric nucleic acid construct comprising in the 5? to 3? direction of transcription as operably linked components: (i) a nucleic acid sequence capable of controlling expression in plant seed cells; and (ii) a nucleic acid sequence encoding an insulin polypeptide; (b) introducing the chimeric nucleic acid construct into a plant cell; and (c) growing the plant cell into a mature plant capable of setting seed wherein the seed expresses insulin.Type: ApplicationFiled: June 17, 2004Publication date: February 17, 2005Inventors: Maurice Moloney, Joseph Boothe, Richard Keon, Cory Nykiforuk, Gijs Van Rooijen
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Patent number: 6761914Abstract: The present invention provides novel adjuvants which comprise oil bodies. The invention also provides vaccine formulations comprising oil bodies and an antigen and methods for preparing the vaccines and the use of the vaccines to elicit an immune response.Type: GrantFiled: June 15, 2001Date of Patent: July 13, 2004Assignee: SemBioSys Genetics Inc.Inventors: Harm M. Deckers, Gijs van Rooijen, Joseph Boothe, Janis Goll, Maurice M. Moloney, Anthony B. Schryvers, Joenel Alcantara, Wendy A. Hutchins
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Patent number: 6599513Abstract: The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in products for topical application to the skin. The products are very mild to the skin and may be easily formulated into a wide variety of personal care and dermatological products.Type: GrantFiled: October 24, 2001Date of Patent: July 29, 2003Assignee: Sembiosys Genetics Inc.Inventors: Harm M. Deckers, Gijs Van Rooijen, Joseph Boothe, Janis Goll, Maurice M. Moloney
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Patent number: 6596287Abstract: The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in products for topical application to the skin. The products are very mild to the skin and may be easily formulated into a wide variety of personal care and dermatological products.Type: GrantFiled: October 24, 2001Date of Patent: July 22, 2003Assignee: SemiBioSys Genetics Inc.Inventors: Harm M. Deckers, Gijs van Rooijen, Joseph Boothe, Janis Goll, Maurice M. Moloney
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Patent number: 6582710Abstract: The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in products for topical application to the skin. The products are very mild to the skin and may be easily formulated into a wide variety of personal care and dermatological products.Type: GrantFiled: January 29, 2002Date of Patent: June 24, 2003Assignee: Sembiosys Genetics Inc.Inventors: Harm M. Deckers, Gijs van Rooijen, Joseph Boothe, Janis Goll, Maurice M. Moloney
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Publication number: 20030096320Abstract: A method for the separation of a target molecule from a mixture is described. The method employs oil bodies and their associated proteins as affinity matrices for the selective, non-covalent binding of desired target molecules. The oil body proteins may be genetically fused to a ligand having specificity for the desired target molecule. Native oil body proteins can also be used in conjunction with an oil body protein specific ligand such as an antibody or an oil body binding protein. The method allows the separation and recovery of the desired target molecules due to the difference in densities between oil bodies and aqueous solutions.Type: ApplicationFiled: October 1, 2002Publication date: May 22, 2003Applicant: SemBioSys Genetics Inc.Inventors: Maurice Moloney, Joseph Boothe, Gijs Van Rooijen
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Publication number: 20030059910Abstract: A method for the separation of a target molecule from a mixture is described. The method employs oil bodies and their associated proteins as affinity matrices for the selective, non-covalent binding of desired target molecules. The oil body proteins may be genetically fused to a ligand having specificity for the desired target molecule. Native oil body proteins can also be used in conjunction with an oil body protein specific ligand such as an antibody or an oil body binding protein. The method allows the separation and recovery of the desired target molecules due to the difference in densities between oil bodies and aqueous solutions.Type: ApplicationFiled: October 1, 2002Publication date: March 27, 2003Applicant: SemBioSys Genetics Inc.Inventors: Maurice Moloney, Joseph Boothe, Gijs Van Rooijen
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Patent number: 6509453Abstract: A method for the separation of a target molecule from a mixture is described. The method employs oil bodies and their associated proteins as affinity matrices for the selective, non-covalent binding of desired target molecules. The oil body proteins may be genetically fused to a ligand having specificity for the desired target molecule. Native oil body proteins can also be used in conjunction with an oil body protein specific ligand such as an antibody or an oil body binding protein.Type: GrantFiled: August 27, 1999Date of Patent: January 21, 2003Assignee: SemBioSys Genetics Inc.Inventors: Maurice Moloney, Joseph Boothe, Gijs Van Rooijen
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Publication number: 20020114820Abstract: The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in products for topical application to the skin. The products are very mild to the skin and may be easily formulated into a wide variety of personal care and dermatological products.Type: ApplicationFiled: January 29, 2002Publication date: August 22, 2002Applicant: SemBioSys Genetics Inc.Inventors: Harm M. Deckers, Gijs Van Rooijen, Joseph Boothe, Janis Goll, Maurice M. Moloney