Abstract: Provided herein are compounds of formula (II): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein m, n, p, R1, R2, R3, L1, L2, L3, R4, X1, X2, X3, and X4 are as defined herein. Also provided are methods of preparing compounds of formula (II), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided are methods of inhibiting APOL1 and methods of treating an APOL1-mediated disease, disorder, or condition in an individual.

Abstract: A wire tire includes an embedment end having first and second ends. First and second leg portions extend from the first and second ends, respectively. First and second moment arms extend from the first and second leg portions, respectively. First and second hook arms extend from the first and second moments arms, respectively.

Abstract: An anchor includes a barrel having a bore extending therethrough. First and second wings extend laterally from the barrel. Further, first and second grooves are provided within the first and second wings, respectively.

Abstract: A spacer for an anchor includes a base having first and second sides. The first side is adapted for engagement with an anchor. At least two spikes extend from the second end of the base. An opening is provided within the base.

Abstract: A spacer for an anchor includes a base having first and second sides. The first side is adapted for engagement with an anchor. At least two spikes extend from the second end of the base. An opening is provided within the base.

Abstract: A wire tire includes an embedment end having first and second ends. First and second leg portions extend from the first and second ends, respectively. First and second moment arms extend from the first and second leg portions, respectively. First and second hook arms extend from the first and second moments arms, respectively.

Abstract: In accordance with one aspect of the present invention, a load transfer system includes a back-up wall and at least one panel disposed adjacent the back-up wall. A veneer wall is spaced from the back-up wall. A drill bolt having a generally cylindrical shaft extending between first and second ends is provided. A portion of the shaft adjacent the first end is secured to the back-up wall and a portion of the shaft adjacent the second end extends through a penetration hole in the at least one panel. A clip is disposed on the second end of the drill bolt within the space between the back-up wall and the veneer wall. A wire tie extends between the clip and the veneer wall.

Abstract: A system includes a back up wall and a veneer wall spaced from the back up wall. An anchor shaft has a first end secured to the back up wall, and a second free end of the shaft projects into a space between the back up wall and the veneer wall. A wing nut has a central barrel disposed on the shaft proximate the free end. The wing nut is spaced apart from a surface of the back up wall. A first generally planar side wing extends laterally from the central barrel of the wing nut. A second generally planar side wing extends laterally from the central barrel. The first side wing includes a first opening for receipt of a first wire tie leg, and the second side wing includes a second opening for receipt of a second wire tie leg. The wing nut is independently rotatable relative to the shaft to angularly orient the wings and thus the openings as desired.

Abstract: A connecting device for joining a wall to a building frame, or for joining walls, comprises a hook member. The frame can comprise steel beams, or also comprise a truss having an open web, and a slide rail attached to the truss' chords in a generally plumb orientation. Embodiments of the hook member substantially encircle one or more slide rails and thereby retain the rails. Other embodiments fit within a channel attached to solid steel webs, or concrete frames. The device's other end is positioned over a course of masonry units, and when embedded in mortar, the cells of the masonry units do not require grouting. Other connecting device embodiments comprise an anchor member securely joined to the member, the connecting device providing multiple points of attachment with the masonry, or multiple members joined to the anchor member. The connecting device can be used for new construction, and in renovations using currently existing steel and concrete frames.

Abstract: A system includes a back up wall and a veneer wall spaced from the back up wall. An anchor shaft has a first end secured to the back up wall, and a free end of the shaft projects into a space between the back up wall and the veneer wall. A wing nut has a central barrel disposed on the shaft proximate the free end. The wing nut is spaced apart from a surface of the back up wall and has a generally planar wing extending from an end of the central barrel wherein the wing includes at least one opening for receipt of a wire tie. The wing nut is independently rotatable about the shaft to angularly orient the wings and thus the at least one opening as desired.

Abstract: A system includes a back up wall and a veneer wall spaced from the back up wall. An anchor shaft has a first end secured to the back up wall, and a second free end of the shaft projects into a space between the back up wall and the veneer wall. A wing nut has a central barrel disposed on the shaft proximate the free end. The wing nut is spaced apart from a surface of the back up wall. A first generally planar side wing extends laterally from the central barrel of the wing nut. A second generally planar side wing extends laterally from the central barrel. The first side wing includes a first opening for receipt of a first wire tie leg, and the second side wing includes a second opening for receipt of a second wire tie leg. The wing nut is independently rotatable relative to the shaft to angularly orient the wings and thus the openings as desired.

Abstract: A connecting device for joining a wall to a building frame, or for joining walls, comprises a hook member. The frame can comprise steel beams, or also comprise a truss having an open web, and a slide rail attached to the truss' chords in a generally plumb orientation. Embodiments of the hook member substantially encircle one or more slide rails and thereby retain the rails. Other embodiments fit within a channel attached to solid steel webs, or concrete frames. The device's other end is positioned over a course of masonry units, and when embedded in mortar, the cells of the masonry units do not require grouting. Other connecting device embodiments comprise an anchor member securely joined to the member, the connecting device providing multiple points of attachment with the masonry, or multiple members joined to the anchor member. The connecting device can be used for new construction, and in renovations using currently existing steel and concrete frames.