Abstract: The disclosure provides methods and related kits, reagents, and systems for selectively deaminating unmethylated cytosine residues in nucleic acid molecules. In some embodiments, the methods and related kits, reagents, and systems are applied for methods of detecting and/or mapping methylated cytosine residues in nucleic acids. The nucleic can be RNA or DNA. Some embodiments include contacting the polynucleic acid with a bacterial cytosine deaminase, for example DddA or SsdA, or functional fragments or derivatives thereof. Representative DddA and SsdA have sequences set forth in SEQ ID NOS:1 and 2, respectively. The bacterial cytosine deaminases of the disclosure are sensitive to methylation and, thus, deaminate only unmethylated cytosines to provide a cytosine to uracil conversion. The conversion can be detected as a C•G-to-T•A transitions in subsequent sequencing analysis.

Abstract: Protective barrier includes a soft metal that inhibits or delays thermal or grinding attack tool penetration. The soft metal, which may be disposed between other layers and otherwise delays thermal attack by expanding or “puffing” during attack. The soft metal can inhibit mechanical attack by rapid ablation and wear of a cutting wheel or blade. The protective barrier may additionally include an oxide or carbide layer.

Abstract: Provided are organic light emitting devices (OLED) comprising an anode; a cathode, and an organic layer between the anode and the cathode, the organic layer comprising a light-emitting dopant within a host material, the light-emitting dopant being an optically active Pt complex comprising a tetradentate ligand; wherein one enantiomer of the optically active Pt complex is present in an enantiomeric excess (ee) of at least 5%. Further provided are OLEDs comprising an anode, a cathode, and an organic layer between the anode and the cathode, the organic layer the organic layer comprising a light-emitting chiral dopant within a chiral host material, the light-emitting chiral dopant being an optically active complex; wherein one enantiomer of the optically active complex of the chiral dopant is present in an ee of at least 5%, and wherein one enantiomer of the chiral host material is present in an ee of at least 5%.

Abstract: Provided herein are compounds of Formula (I) and Formula (II) and stereoisomers, tautomers, and pharmaceutically acceptable salts or solvates thereof. Also provided are pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition by using the compounds and pharmaceutical compositions.

Abstract: There is provided a transducer structure having at least one mechanical restraint. The at least one mechanical restraint is shaped to receive a transducer such that the at least one mechanical restraint at least partially limits the positioning of the transducer on the transducer structure. The at least one mechanical restraint pins at least a portion of the transducer in at least two degrees of freedom when the transducer is positioned on the transducer structure.

Abstract: Aspects of the present invention relate to method of controlling a supply of purge gas to reduce leakage past a dynamic seal (10). The dynamic seal (10) comprising at least a first sealing member (12-1) having opposing first and second sides (12-1A, 12-1B). A pressure differential (?P) is determined between a first operating pressure (P1) on the first side of the first sealing member (12-1) and a second operating pressure (P2) on the second side of the first sealing member (12-1). The supply of purge gas to the second side of the first sealing member (12-1) is controlled in dependence on the determined pressure differential (?P). Aspects of the invention relate to a controller (23) for controlling a supply of purge gas; a dynamic sealing system (1) for a vacuum system (2); and a vacuum system (2).

Abstract: A system to enable mobile marketing communication that includes a vehicular window coupled to a vehicle, an electronic display positioned adjacent to the vehicular window, and an information store that includes adverts. A vehicular state sensor is positioned proximate to the vehicular window and configured to detect driving events associated with the vehicle. A control circuit is communicatively coupled to the electronic display, the information store, and the vehicular state sensor. The control circuit is configured to determine, via the vehicular state sensor, the driving events. The control circuit is further configured to convey, via the electronic display, an advert when the driving event is a left turn, a right turn, a reversing state, or a parked state. The vehicular state sensor include lateral and longitudinal accelerometers that detect the lateral and longitudinal acceleration of the vehicle.

Abstract: The present invention provides value tokens having improved security while achieving enhanced decorative effects, contrasting edge “spots”, increased physical weight, and flexibility of construction and design. Stacked structures formed from pluralities of layers are featured.

Abstract: Value tokens, e.g. gaming chips, are formed with a slug having an RFID microchip embedded or encapsulated inside and an EM coil either embedded or encapsulated inside or wrapped around the periphery of the slug. The slug is formed by injection molding two plastic halves with a spacing therebetween for accepting the RFID microchip. The plastic halves are formed from weighted plastic including fillers such as copper, brass and/or tungsten to add extra weight to the plastic halves. The EM coil is placed on the same radius as the RFID antenna within the gaming chip or at a radius outside the RFID antenna to as to minimize interference between the RFID and EM signals by minimizing the metal in the EM field. For example, the EM coil may be wound within a groove around the outer periphery of the slug.

Abstract: Value tokens, e.g. gaming chips, are formed with a slug having an RFID microchip embedded or encapsulated inside and an EM coil either embedded or encapsulated inside or wrapped around the periphery of the slug. The slug is formed by injection molding two plastic halves with a spacing therebetween for accepting the RFID microchip. The plastic halves are formed from weighted plastic including fillers such as copper, brass and/or tungsten to add extra weight to the plastic halves. The EM coil is placed on the same radius as the RFID antenna within the gaming chip or at a radius outside the RFID antenna to as to minimize interference between the RFID and EM signals by minimizing the metal in the EM field. For example, the EM coil may be wound within a groove around the outer periphery of the slug.

Abstract: The present invention provides value tokens having improved security while achieving enhanced decorative effects, contrasting edge “spots”, increased physical weight, and flexibility of construction and design. Stacked structures formed from pluralities of layers are featured.

Abstract: A thermal control film for use in spacecraft having a multi-layer interference filter adapted to exhibit high reflectivity to solar radiation, low absorptivity across the microwave spectrum and high emissivity in the far infra-red. The film is free from metal and extends over the active face of an antenna carried by the spacecraft. Such a film exhibits the desired thermo-optical properties for a thermal control radiator surface and can be used over the active face of a communications or radar antenna without disrupting the RF signal.

Abstract: The illustrative embodiments described herein provide a computer implemented method, apparatus, and computer program product for directing a movement of visitors in an event venue. In one embodiment, the process generates a visitor profile for each visitor at an event venue. The visitor profile may include, without limitation, a unique identifier and location data. The location data is collected from a set of sensors distributed throughout the event venue. The process then monitors a capacity of visitors at each venue destination using the location data. In response to determining that the capacity of visitors at a first venue destination exceeds a threshold capacity for the first venue destination, the process selects a second venue destination for accommodating visitors of the first venue destination. The process selects the second venue destination based on selection criteria.

Abstract: A web services endpoint emulator for testing and developing web server client program, which generates emulator service classes according to service descriptor files, the classes being contained in a web container accessible by a web server; receives by the web server a request from a client process via an emulator interface; parses the request and any associated parameters; retrieves endpoint service descriptor files according to the parsed request and parameters; executes by a web server a service response script while evaluating the retrieved endpoint service descriptor files to generate a response; and sends from the web server the generated response to the client process via the emulator interface.

Abstract: The illustrative embodiments described herein provide a computer implemented method, apparatus, and computer program product for directing a movement of visitors in an event venue. In one embodiment, the process generates a visitor profile for each visitor at an event venue. The visitor profile may include, without limitation, a unique identifier and location data. The location data is collected from a set of sensors distributed throughout the event venue. The process then monitors a capacity of visitors at each venue destination using the location data. In response to determining that the capacity of visitors at a first venue destination exceeds a threshold capacity for the first venue destination, the process selects a second venue destination for accommodating visitors of the first venue destination. The process selects the second venue destination based on selection criteria.

Abstract: A method, system, and computer program product are described for managing the provisioning of resources in a data processing system. There are different types of resources. Each resource is one of these types. Multiple provisioning states are defined for each type of resource. Relationships are defined among the provisioning states. The relationships describe valid transitions from one state to another. Workflows of one or more tasks are defined, varying to the resource implementation specifications, that are associated with each one of the valid transitions between states. When a resource is to transition from a current state, the relationships among states are used to determine a valid next state. The workflow specific to the resource specification and associated with this transition from the current state to the determined next state is then executed in order to transition to the next state.

Abstract: A method, system, and computer program product are disclosed for logically provisioning resources in a data processing system. A request for one or more resources to be provisioned in a provisioning environment is received. The requested resources may be of multiple different available types of resources. Particular instances of the requested types of resources are selected from a group of different types of unassigned available resources. The selected resources are indicated as being reserved, and thus no longer unassigned or available, to fulfill this request. The selected resources are then logically provisioned by establishing logical relationships between the selected resource instances in the provisioning environment.

Abstract: A web services endpoint emulator for testing and developing web server client program, which generates a service interface and makes the interface available for client consumption. Service interfaces are exposed with configuration options for each service. The configuration options produced by the invention includes pre-configured responses or the ability to prescript service responses from a configuration file, and to prompt a user for input during real time emulation of an endpoint service.

Abstract: An endpoint emulator of an endpoint service in a network computer arrangement which generates emulator service classes according to service descriptor files, the classes being Web Services Description Language descriptors contained in a web container, provides an emulator console, receives and parses a request from a client process, via an emulator interface, retrieves endpoint service descriptor files according to the request, wherein the endpoint service description files are associated with a web services endpoint for performing a function on behalf of a client program based upon data supplied by the client program, executes a service response script while evaluating said retrieved endpoint service descriptor files to generate a response, and sends the generated response to the client process.

Abstract: A method for providing the ability for systems personnel to use a personal wireless device, such as a mobile phone, palm device, or blackberry device, to receive a system alert regarding a developing situation requiring action and to be notified of pre-selected workflows that can resolve the situation prompting the alert. The systems personnel are then able to select a workflow, provide needed parameters, and provide the human approval to execute the workflow. The application packages the information provided by the user into a form usable by the orchestration/provisioning server. The server will perform the requested workflow as if entered on a local console and will respond to the device with a workflow status.