Patents by Inventor Joseph C. Hogan
Joseph C. Hogan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7034110Abstract: A method for obtaining compounds having selected properties for a particular application by forming base modules having at least two structural diversity elements from the reaction of a first compound having at least one structural diversity element and a first reactive group, with a second compound having at least one structural diversity element and a second reactive group, wherein the first and second groups combine by an addition reaction; producing a first array of molecules by varying at least one of the structural diversity elements of the compounds when producing the base modules; and screening the array to determine a first suitable compound for the particular application. The base modules are preferably formed form oxazolone- and aminimide-derived compounds.Type: GrantFiled: January 23, 2004Date of Patent: April 25, 2006Assignee: ArQule, Inc.Inventor: Joseph C. Hogan, Jr.
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Patent number: 6878557Abstract: A method for constructing an array of synthetic molecular constructs, by forming a plurality of molecular constructs having a scaffold backbone of a chemical molecule comprising a linear, branched or cyclic organic compound having at least atoms of carbon, nitrogen, sulfur, phosphorus, or combinations thereof, and at least one location on the molecule capable of undergoing reaction with other molecules for attachment of at least one structural diversity element; laying out an array possessing a logical ordering of sub-arrays of the molecular constructs; providing each sub-array with molecular constructs having the scaffold backbone and at least one structural diversity element which is different from the others; and relating each sub-array within the array to all other sub arrays by the difference in the structural diversity elements.Type: GrantFiled: January 20, 1998Date of Patent: April 12, 2005Assignee: ArQule, Inc.Inventors: Robert Zambias, David A. Bolten, Joseph C. Hogan, Paul Furth, David Casebier, Cheng Tu
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Publication number: 20040161610Abstract: A method for obtaining compounds having selected properties for a particular application by forming base modules having at least two structural diversity elements from the reaction of a first compound having at least one structural diversity element and a first reactive group, with a second compound having at least one structural diversity element and a second reactive group, wherein the first and second groups combine by an addition reaction; producing a first array of molecules by varying at least one of the structural diversity elements of the compounds when producing the base modules; and screening the array to determine a first suitable compound for the particular application. The base modules are preferably formed form oxazolone- and aminimide-derived compounds.Type: ApplicationFiled: January 23, 2004Publication date: August 19, 2004Inventor: Joseph C. Hogan
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Patent number: 6271195Abstract: The design and synthesis of novel aminimide-based molecular modules and the use of the modules in the construction of new molecules and fabricated materials is disclosed. The new molecules and fabricated materials are molecular recognition agents useful in the design and synthesis of drugs, and have applications in separations and materials science.Type: GrantFiled: October 22, 1999Date of Patent: August 7, 2001Assignee: Arqule, Inc.Inventor: Joseph C. Hogan, Jr.
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Patent number: 5981467Abstract: The design and synthesis of novel aminimide-based molecular modules and the use of the modules in the construction of new molecules and fabricated materials is disclosed. The new molecules and fabricated materials are molecular recognition agents useful in the design and synthesis of drugs, and have applications in separations and materials science.Type: GrantFiled: February 16, 1996Date of Patent: November 9, 1999Assignee: Arqule, Inc.Inventor: Joseph C. Hogan, Jr.
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Patent number: 5962736Abstract: A logically ordered array of 10,240 different compounds, each compound prepared from the reaction product of an oxazolone, aldehyde and amine.Type: GrantFiled: January 26, 1998Date of Patent: October 5, 1999Assignee: Arqule, Inc.Inventors: Robert Zambias, David A. Bolten, Joseph C. Hogan, Paul Furth, David Casebier, Cheng Tu
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Patent number: 5962412Abstract: A method of making a polymer having specific physiochemical properties by forming a first module having a structure which includes at least two structural diversity elements suitable to impart a desired physical property to a polymer which is made from said monomer; and reacting one or more modules to form a polymer having specific physiochemical properties. The base module can be formed by reacting a first compound having at least one structural diversity element and a first reactive group, with a second compound having at least one structural diversity element and a second reactive group, wherein the first and second groups combine by an addition reaction. Specifically, an aminimide compound, an oxazolone compound or derivatives thereof are useful as base modules in the invention.Type: GrantFiled: September 16, 1997Date of Patent: October 5, 1999Assignee: Arqule, Inc.Inventor: Joseph C. Hogan, Jr.
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Patent number: 5892113Abstract: This invention relates to a class of aminimides structurally characterized as an acyl nitrogen-nitrogen ylide such that the acyl moiety possess the structural diversity element G, the quaternary nitrogen possess structural diversity elements E and F, and the quaternary nitrogen is bonded to a hydroxyethyl substituent, which in turn is bonded to an aminomethylene moiety that possess structural diversity elements A and B from the amino group and diversity element c from the methylene substituent, as shown below, ##STR1## wherein structural diversity element A, B, C, D, E, F and G are chosen from the set of elements consisting of substituted and unsubstituted as well as branched and straight chain alkyl, aryl, alkaryl, aralkyl, carbocyclic, heterocyclic, hydrogen, amino acid, peptide, polypeptide, protein, depsipeptide, carbohydrate derivatives, nucleotide derivatives, oligonucleotide derivatives, naturally occurring or synthetic organic structural motifs, reporter elements, organic moieties containing at leastType: GrantFiled: December 29, 1997Date of Patent: April 6, 1999Assignee: Arqule, Inc.Inventors: Joseph C. Hogan, Jr., David Casebier, Paul S. Furth, Steve Gallion, Alan Kaplan
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Patent number: 5807754Abstract: An n.times.m.times.p array of different chemical compounds, each having the following scaffold structure: ##STR1## wherein n, m and p are integers, A, B and C are organic structural moieties representing diversity elements. The novel compounds present in this array are useful as inhibitors of binding of Rev protein to a Rev response element.Type: GrantFiled: May 11, 1995Date of Patent: September 15, 1998Assignee: Arqule, Inc.Inventors: Robert Zambias, David A. Bolten, Joseph C. Hogan, Paul Furth, David Casebier, Cheng Tu, Jaime E. Arenas
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Patent number: 5736412Abstract: This invention is directed to an m.times.n array of different chemical compounds wherein each of said compounds has at least one structural diversity element selected from a group of amines and ketones and wherein the scaffold structure is selected from a group consisting of aminimide, imidazolone, sulfonylaminimide and phosphonylaminimide.Type: GrantFiled: May 17, 1996Date of Patent: April 7, 1998Assignee: ArQule, Inc.Inventors: Robert Zambias, David A. Bolten, Joseph C. Hogan, Paul Furth, David Casebier, Cheng Tu
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Patent number: 5734082Abstract: This invention relates to a class of aminimides structurally characterized as an acyl nitrogen-nitrogen ylide such that the acyl moiety possess the structural diversity element G, the quaternary nitrogen possess structural diversity elements E and F, and the quaternary nitrogen is bonded to a hydroxyethyl substituent, which in turn is bonded to an aminomethylene moiety that possess structural diversity elements A and B from the amino group and diversity element C from the methylene substituent, as shown below, ##STR1## wherein structural diversity element A, B, C, D, E, F and G are chosen from the set of elements consisting of substituted and unsubstituted as well as branched and straight chain alkyl, aryl, alkaryl, aralkyl, carbocyclic, heterocyclic, hydrogen, amino acid, peptide, polypeptide, protein, depsipeptide, carbohydrate derivatives, nucleotide derivatives, oligonucleotide derivatives, naturally occurring or synthetic organic structural motifs, reporter elements, organic moieties containing at leastType: GrantFiled: October 20, 1994Date of Patent: March 31, 1998Assignee: Arqule Inc.Inventors: Joseph C. Hogan, Jr., David Casebier, Paul S. Purth, Steve Gallion, Alan Kaplan
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Patent number: 5712171Abstract: A method for constructing an array of synthetic molecular constructs, by forming a plurality of molecular constructs having a scaffold backbone of a chemical molecule comprising a linear, branched or cyclic organic compound having at least atoms of carbon, nitrogen, sulfur, phosphorus, or combinations thereof, and at least one location on the molecule capable of undergoing reaction with other molecules for attachment of at least one structural diversity element; laying out an array possessing a logical ordering of sub-arrays of the molecular constructs; providing each sub-array with molecular constructs having the scaffold backbone and at least one structural diversity element which is different from the others; and relating each sub-array within the array to all other sub arrays by the difference in the structural diversity elements.Type: GrantFiled: January 20, 1995Date of Patent: January 27, 1998Assignee: ArQule, Inc.Inventors: Robert Zambias, David A. Bolten, Joseph C. Hogan, Paul Furth, David Casebier, Cheng Tu
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Patent number: 5705585Abstract: The design and synthesis of novel aminimide-based molecular modules and the use of the same in the construction of new molecules and fabricated materials is disclosed. The new molecules and fabricated materials are molecular recognition agents useful in the design and synthesis of drugs and have applications in separations and material science.Type: GrantFiled: March 27, 1995Date of Patent: January 6, 1998Assignee: ArQule, Inc.Inventor: Joseph C. Hogan, Jr.
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Patent number: 5670480Abstract: A method of making a polymer having specific physiochemical properties by forming a first module having a structure which includes at least two structural diversity elements suitable to impart a desired physical property to a polymer which is made from said monomer; and reacting one or more modules to form a polymer having specific physiochemical properties. The base module can be formed by reacting a first compound having at least one structural diversity element and a first reactive group, with a second compound having at least one structural diversity element and a second reactive group, wherein the first and second groups combine by an addition reaction. Specifically, an aminimide compound, an oxazolone compound or derivatives thereof are useful as base modules in the invention.Type: GrantFiled: June 10, 1996Date of Patent: September 23, 1997Assignee: ArQule, Inc.Inventor: Joseph C. Hogan, Jr.