Patents by Inventor Joseph C. Hogan, Jr.

Joseph C. Hogan, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7034110
    Abstract: A method for obtaining compounds having selected properties for a particular application by forming base modules having at least two structural diversity elements from the reaction of a first compound having at least one structural diversity element and a first reactive group, with a second compound having at least one structural diversity element and a second reactive group, wherein the first and second groups combine by an addition reaction; producing a first array of molecules by varying at least one of the structural diversity elements of the compounds when producing the base modules; and screening the array to determine a first suitable compound for the particular application. The base modules are preferably formed form oxazolone- and aminimide-derived compounds.
    Type: Grant
    Filed: January 23, 2004
    Date of Patent: April 25, 2006
    Assignee: ArQule, Inc.
    Inventor: Joseph C. Hogan, Jr.
  • Patent number: 6271195
    Abstract: The design and synthesis of novel aminimide-based molecular modules and the use of the modules in the construction of new molecules and fabricated materials is disclosed. The new molecules and fabricated materials are molecular recognition agents useful in the design and synthesis of drugs, and have applications in separations and materials science.
    Type: Grant
    Filed: October 22, 1999
    Date of Patent: August 7, 2001
    Assignee: Arqule, Inc.
    Inventor: Joseph C. Hogan, Jr.
  • Patent number: 5981467
    Abstract: The design and synthesis of novel aminimide-based molecular modules and the use of the modules in the construction of new molecules and fabricated materials is disclosed. The new molecules and fabricated materials are molecular recognition agents useful in the design and synthesis of drugs, and have applications in separations and materials science.
    Type: Grant
    Filed: February 16, 1996
    Date of Patent: November 9, 1999
    Assignee: Arqule, Inc.
    Inventor: Joseph C. Hogan, Jr.
  • Patent number: 5962412
    Abstract: A method of making a polymer having specific physiochemical properties by forming a first module having a structure which includes at least two structural diversity elements suitable to impart a desired physical property to a polymer which is made from said monomer; and reacting one or more modules to form a polymer having specific physiochemical properties. The base module can be formed by reacting a first compound having at least one structural diversity element and a first reactive group, with a second compound having at least one structural diversity element and a second reactive group, wherein the first and second groups combine by an addition reaction. Specifically, an aminimide compound, an oxazolone compound or derivatives thereof are useful as base modules in the invention.
    Type: Grant
    Filed: September 16, 1997
    Date of Patent: October 5, 1999
    Assignee: Arqule, Inc.
    Inventor: Joseph C. Hogan, Jr.
  • Patent number: 5892113
    Abstract: This invention relates to a class of aminimides structurally characterized as an acyl nitrogen-nitrogen ylide such that the acyl moiety possess the structural diversity element G, the quaternary nitrogen possess structural diversity elements E and F, and the quaternary nitrogen is bonded to a hydroxyethyl substituent, which in turn is bonded to an aminomethylene moiety that possess structural diversity elements A and B from the amino group and diversity element c from the methylene substituent, as shown below, ##STR1## wherein structural diversity element A, B, C, D, E, F and G are chosen from the set of elements consisting of substituted and unsubstituted as well as branched and straight chain alkyl, aryl, alkaryl, aralkyl, carbocyclic, heterocyclic, hydrogen, amino acid, peptide, polypeptide, protein, depsipeptide, carbohydrate derivatives, nucleotide derivatives, oligonucleotide derivatives, naturally occurring or synthetic organic structural motifs, reporter elements, organic moieties containing at least
    Type: Grant
    Filed: December 29, 1997
    Date of Patent: April 6, 1999
    Assignee: Arqule, Inc.
    Inventors: Joseph C. Hogan, Jr., David Casebier, Paul S. Furth, Steve Gallion, Alan Kaplan
  • Patent number: 5734082
    Abstract: This invention relates to a class of aminimides structurally characterized as an acyl nitrogen-nitrogen ylide such that the acyl moiety possess the structural diversity element G, the quaternary nitrogen possess structural diversity elements E and F, and the quaternary nitrogen is bonded to a hydroxyethyl substituent, which in turn is bonded to an aminomethylene moiety that possess structural diversity elements A and B from the amino group and diversity element C from the methylene substituent, as shown below, ##STR1## wherein structural diversity element A, B, C, D, E, F and G are chosen from the set of elements consisting of substituted and unsubstituted as well as branched and straight chain alkyl, aryl, alkaryl, aralkyl, carbocyclic, heterocyclic, hydrogen, amino acid, peptide, polypeptide, protein, depsipeptide, carbohydrate derivatives, nucleotide derivatives, oligonucleotide derivatives, naturally occurring or synthetic organic structural motifs, reporter elements, organic moieties containing at least
    Type: Grant
    Filed: October 20, 1994
    Date of Patent: March 31, 1998
    Assignee: Arqule Inc.
    Inventors: Joseph C. Hogan, Jr., David Casebier, Paul S. Purth, Steve Gallion, Alan Kaplan
  • Patent number: 5705585
    Abstract: The design and synthesis of novel aminimide-based molecular modules and the use of the same in the construction of new molecules and fabricated materials is disclosed. The new molecules and fabricated materials are molecular recognition agents useful in the design and synthesis of drugs and have applications in separations and material science.
    Type: Grant
    Filed: March 27, 1995
    Date of Patent: January 6, 1998
    Assignee: ArQule, Inc.
    Inventor: Joseph C. Hogan, Jr.
  • Patent number: 5670480
    Abstract: A method of making a polymer having specific physiochemical properties by forming a first module having a structure which includes at least two structural diversity elements suitable to impart a desired physical property to a polymer which is made from said monomer; and reacting one or more modules to form a polymer having specific physiochemical properties. The base module can be formed by reacting a first compound having at least one structural diversity element and a first reactive group, with a second compound having at least one structural diversity element and a second reactive group, wherein the first and second groups combine by an addition reaction. Specifically, an aminimide compound, an oxazolone compound or derivatives thereof are useful as base modules in the invention.
    Type: Grant
    Filed: June 10, 1996
    Date of Patent: September 23, 1997
    Assignee: ArQule, Inc.
    Inventor: Joseph C. Hogan, Jr.