Abstract: The present application provides tricyclic urea compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

Abstract: An assembly and a method for manufacturing an assembly for transmitting torque to an aircraft actuator. The assembly and method include a torque tube having a longitudinal axis and an end fitting. The ending fitting includes a connector portion and an engagement portion that is inserted into the torque tube. The engagement portion includes a first end adjacent the connector portion, a second end opposite the first end, and a coupling region between the first and second end that includes an outer coupling surface having an outer diameter and a continuous groove formed thereon. The continuous groove includes two axial grooves that extend along the outer coupling surface along the longitudinal axis and a first parallel groove that extends circumferentially about the longitudinal axis along the outer coupling surface that joins the two axial grooves.

Abstract: A system and method for preventing fraudulent calling activities of computer data systems such as a Private Branch Exchanges (PBX) accessed through dial-up telephone lines via a remote maintenance or administration port. The system is readily adaptable to existing PBX systems without the need to alter PBX hardware or software configurations. The system includes a device to passively monitor calling activity conducted through the remote port of the PBX without alerting the caller in order to detect a condition of activity indicative of fraud. The monitoring device may include rule based expert system software to analyze call transmission data for activities outside the norm that are indicative of fraud. Alternatively, the monitoring device may include software or hardware for comparing call digit origination data to a database of authorized call activity contained within the monitoring device.