Patents by Inventor Joseph C. Trautman
Joseph C. Trautman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150079133Abstract: A microprojection array is provided, comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a vaccine and a polymeric material. The array may have multiple layers. The vaccine may be placed in only one layer. In another embodiment of the invention, a method of preventing a disease is provided, comprising insertion into the skin of a patient an array of microprojections comprising a layer which comprises a vaccine for that disease and a polymer.Type: ApplicationFiled: November 20, 2014Publication date: March 19, 2015Inventors: Esi Ghartey-Tagoe, Janet Wendorf, Steve Williams, Parminder Singh, Robert Wade Worsham, Joseph C. Trautman, Danir Bayramov, Danny Lee Bowers, Andrew Richard Klemm, Steven Richard Klemm, Guohua Chen
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Patent number: 8911749Abstract: A microprojection array is provided, comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a vaccine and a polymeric material. The array may have multiple layers. The vaccine may be placed in only one layer. In another embodiment of the invention, a method of preventing a disease is provided, comprising insertion into the skin of a patient an array of microprojections comprising a layer which comprises a vaccine for that disease and a polymer.Type: GrantFiled: October 10, 2008Date of Patent: December 16, 2014Assignee: Corium International, Inc.Inventors: Esi Ghartey-Tagoe, Janet Wendorf, Steve Williams, Parminder Singh, Robert Wade Worsham, Joseph C. Trautman, Danir Bayramov, Danny Lee Bowers, Andy Klemm, Steven Richard Klemm, Guohua Chen
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Publication number: 20140364801Abstract: A retainer (34) is provided for holding a microprotrusion member (44) for application of the microprotrusion member (44) to the stratum corneum with an impact applicator (10). The microprotrusion member (44) includes a plurality of microprotrusions (90) which penetrate the stratum corneum to improve transport of an agent across the stratum corneum.Type: ApplicationFiled: June 17, 2014Publication date: December 11, 2014Inventors: Joseph C. Trautman, Richard L. Keenan
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Patent number: 8821446Abstract: A microneedle applicator is provided which has two roughly concentric portions which may be, for example, a solid disk and an annulus surrounding it. On the skin-facing side of the inner portion of the applicator a microneedle array is located. The outer portion of the applicator is placed against the skin, contacting it at a zone. The microneedle array is then pressed towards the skin.Type: GrantFiled: January 22, 2008Date of Patent: September 2, 2014Assignee: Corium International, Inc.Inventors: Joseph C. Trautman, Robert Wade Worsham, Danir F. Bayramov, Danny Lee Bowers, Steven Richard Klemm, Parminder Singh
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Patent number: 8753318Abstract: A retainer (34) is provided for holding a microprotrusion member (44) for application of the microprotrusion member (44) to the stratum corneum with an impact applicator (10). The microprotrusion member (44) includes a plurality of microprotrusions (90) which penetrate the stratum corneum to improve transport of an agent across the stratum corneum.Type: GrantFiled: November 1, 2004Date of Patent: June 17, 2014Assignee: Alza CorporationInventors: Joseph C. Trautman, Richard L. Keenan
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Publication number: 20130292868Abstract: In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient.Type: ApplicationFiled: July 10, 2013Publication date: November 7, 2013Inventors: Parminder Singh, Robert Wade Worsham, Joseph C. Trautman, Danir Bayramov, Danny Lee Bowers, Andy Klemm, Steven Richard Klemm, Guohua Chen
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Publication number: 20130292886Abstract: Methods for the manufacture of a microprojection array are provided. In the methods, a formulation is introduced into cavities of a microprojection array mold by means that achieve a uniform amount of formulation retained in each cavity.Type: ApplicationFiled: July 9, 2013Publication date: November 7, 2013Inventors: Appala Sagi, Joseph C. Trautman, Guohua Chen, Robert Wade Worsham, Parminder Singh
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Publication number: 20110276027Abstract: An applicator for a microprojection array is described. In one embodiment, the applicator comprises an energy-storing element. Application of force causes the compressed energy-storing element to extend or transition from first and second configurations, releasing stored energy to deploy a holding member in the application which is configured to hold an array of microprojections. In another embodiment, the applicator comprises an energy storing element with two stable configurations, a first stable configuration and second stable configuration. Application of force causes the energy-storing element to transition from the higher energy first stable configuration to the lower energy second stable configuration, releasing the difference in energies of the two states to deploy a holding member in the application which is configured to hold an array of microprojections.Type: ApplicationFiled: May 4, 2011Publication date: November 10, 2011Applicant: Corium International, Inc.Inventors: Joseph C. Trautman, Douglas Joseph Scott Bourne, Anthony Le, Robert Wade Worsham, Parminder Singh
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Publication number: 20110006458Abstract: Methods for the manufacture of a microprojection array are provided. In the methods, a formulation is introduced into cavities of a microprojection array mold by means that achieve a uniform amount of formulation retained in each cavity.Type: ApplicationFiled: April 23, 2010Publication date: January 13, 2011Applicant: Corium International, Inc.Inventors: Appala Sagi, Joseph C. Trautman, Guohua Chen, Robert Wade Worsham, Parminder Singh
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Patent number: 7798987Abstract: A method and device are described for applying a microprotrusion member (44) including a plurality of microprotrusions (90) to the stratum corneum with impact. The method and device are used to improve transport of an agent across the skin for agent delivery or sampling. The applicator (10, 60, 80) causes the microprotrusion member (44) to impact the stratum corneum with a certain amount of impact determined to effectively pierce the skin with the microprotrusions (90). The preferred applicator (10, 60, 80) impacts the stratum corneum with the microprotrusion member (44) with an impact of at least 0.05 joules per cm2 of the microprotrusion member (44) in 10 msec or less.Type: GrantFiled: March 28, 2005Date of Patent: September 21, 2010Assignee: Alza CorporationInventors: Joseph C. Trautman, Richard L. Keenan, Ahmad P. Samiee, WeiQi Lin, Michel J. N. Cormier, James A. Matriano, Peter E. Daddona
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Publication number: 20090183673Abstract: An Apparatus and method are provided for selectively applying an agent-containing liquid coating to extremely tiny skin piercing microprojections (10). The coating solution is applied to the skin piercing microprojections (10) using a coating technique which selectively coats only the skin piercing microprojections (10) and not to substrate (12) from which the microprojections (10) extend, and the dried. The coating method includes providing an agent-containing coating liquid and conveying the liquid to a liquid holding surface having a coating transfer region. The depth of the coating liquid at the coating transfer region is precisely controlled. The microprojections are then immersed to a predetermined level in the coating liquid. The liquid that coats the microprojections (10) is then dried to form a solid agent-containing coating on the microprojections (10).Type: ApplicationFiled: October 8, 2008Publication date: July 23, 2009Applicant: ALZA CORPORATIONInventors: Joseph C. Trautman, Cedric T. Wright, Michel J. N. Cormier
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Publication number: 20090155330Abstract: A microprojection array is provided, comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a vaccine and a polymeric material. The array may have multiple layers. The vaccine may be placed in only one layer. In another embodiment of the invention, a method of preventing a disease is provided, comprising insertion into the skin of a patient an array of microprojections comprising a layer which comprises a vaccine for that disease and a polymer.Type: ApplicationFiled: October 10, 2008Publication date: June 18, 2009Applicant: Corium International, Inc.Inventors: Esi Ghartey-Tagoe, Janet Wendorf, Steve Williams, Parminder Singh, Robert Wade Worsham, Joseph C. Trautman, Danir Bayramov, Danny Lee Bowers, Andy Klemm, Steven Richard Klemm, Guohua Chen
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Publication number: 20080269726Abstract: An osmotic pump includes a capsule having at least one delivery port formed at a first end and a membrane plug retained in a second end of the capsule remote from the delivery port to provide a fluid-permeable barrier between an interior and an exterior of the capsule. The membrane plug has a columnar body and at least one slot formed in the columnar body to vent pressure from the interior to the exterior of the capsule when the columnar body extends a predetermined distance relative to the second end of the capsule, thereby preventing expulsion of the membrane plug from the second end.Type: ApplicationFiled: July 1, 2008Publication date: October 30, 2008Inventor: Joseph C. Trautman
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Publication number: 20080269685Abstract: In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient.Type: ApplicationFiled: April 16, 2008Publication date: October 30, 2008Inventors: Parminder Singh, Robert Wade Worsham, Joseph C. Trautman, Danir Bayramov, Danny Lee Bowers, Andy Klemm, Steven Richard Klemm, Guohua Chen
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Patent number: 7435299Abstract: An apparatus and method are provided for selectively applying an agent-containing liquid coating to extremely tiny skin piercing microprojections (10). The coating solution is applied to the skin piercing microprojections (10) using a coating technique which selectively coats only the skin piercing microprojections (10) and not the substrate (12) from which the microprojections (10) extend, and then dried. The coating method includes providing an agent-containing coating liquid and conveying the liquid to a liquid holding surface having a coating transfer region. The depth of the coating liquid at the coating transfer region is precisely controlled. The microprojections are then immersed to a predetermined level in the coating liquid. The liquid that coats the microprojections (10) is then dried to form a solid agent-containing coating on the microprojections (10).Type: GrantFiled: November 9, 2004Date of Patent: October 14, 2008Assignee: ALZA CorporationInventors: Joseph C. Trautman, Cedric T. Wright, Michel J.N. Cormier
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Patent number: 7419481Abstract: A method and device are described for applying a microprotrusion member (44) including a plurality of microprotrusions (90) to the stratum corneum with impact. The method and device are used to improve transport of an agent across the skin for agent delivery or sampling. The applicator (10, 60, 80) causes the microprotrusion member (44) to impact the stratum corneum with a certain amount of impact determined to effectively pierce the skin with the microprotrusions (90). The preferred applicator (10, 60, 80) impacts the stratum corneum with the microprotrusion member (44) with an impact of at least 0.05 joules per cm2 of the microprotrusion member (44) in 10 msec or less.Type: GrantFiled: March 28, 2005Date of Patent: September 2, 2008Assignee: ALZA CorporationInventors: Joseph C. Trautman, Richard L. Keenan, Ahmad P. Samiee, WeiQi Lin, Michel J. N. Cormier, James A. Matriano, Peter E. Daddona
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Patent number: 7407499Abstract: An osmotic pump includes a capsule having at least one delivery port formed at a first end and a membrane plug retained in a second end of the capsule remote from the delivery port to provide a fluid-permeable barrier between an interior and an exterior of the capsule. The membrane plug has a columnar body and at least one slot formed in the columnar body to vent pressure from the interior to the exterior of the capsule when the columnar body extends a predetermined distance relative to the second end of the capsule, thereby preventing expulsion of the membrane plug from the second end.Type: GrantFiled: October 20, 2004Date of Patent: August 5, 2008Assignee: Intarcia Therapeutics, Inc.Inventor: Joseph C. Trautman
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Publication number: 20080183144Abstract: A microneedle applicator is provided which has two roughly concentric portions which may be, for example, a solid disk and an annulus surrounding it. On the skin-facing side of the inner portion of the applicator a microneedle array is located. The outer portion of the applicator is placed against the skin, contacting it at a zone. The microneedle array is then pressed towards the skin.Type: ApplicationFiled: January 22, 2008Publication date: July 31, 2008Inventors: Joseph C. Trautman, Robert Wade Worsham, Danir F. Bayramov, Danny Lee Bowers, Steven Richard Klemm, Parminder Singh
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Publication number: 20070224252Abstract: The present invention provides methods and devices for reducing the coating variability of a transdermal microprojection delivery device. The device includes one or more stratum corneum-piercing microprojections, wherein each microprojection has a capillary control feature that restricts migration of a coating formulation.Type: ApplicationFiled: March 27, 2006Publication date: September 27, 2007Inventors: Joseph C. Trautman, Richard Wilhem Janse Van Rensburg
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Patent number: 7131960Abstract: A method and device are described for applying a microprotrusion member (44) including a plurality of microprotrusions (90) to the stratum corneum with impact. The method and device are used to improve transport of an agent across the skin for agent delivery or sampling. The applicator (10, 60, 80) causes the microprotrusion member (44) to impact the stratum corneum with a certain amount of impact determined to effectively pierce the skin with the microprotrusions (90). The preferred applicator (10, 60, 80) impacts the stratum corneum with the microprotrusion member (44) with an impact of at least 0.05 joules per cm2 of the microprotrusion member (44) in 10 msec or less.Type: GrantFiled: October 12, 2001Date of Patent: November 7, 2006Assignee: Alza CorporationInventors: Joseph C. Trautman, Richard L. Keenan, Ahmad P. Samiee, WeiQi Lin, Michel J. N. Cormier, James A. Matriano, Peter E. Daddona