Patents by Inventor Joseph Cioffi

Joseph Cioffi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Detection of a leptin receptor variant
    Patent number: 5856098
    Abstract: The present invention relates to a variant form of the receptor for the obese gene product. In particular, the invention relates to methods of detecting this receptor variant in cells and tissues of obese individuals. In addition, it relates to methods of inhibiting or down-regulating expression of this variant in cells to augment their responsiveness to weight regulation by leptin as well as methods of using compounds to directly activate signal transduction pathways associated with this ligand-receptor system.
    Type: Grant
    Filed: January 18, 1996
    Date of Patent: January 5, 1999
    Assignee: Progenitor, Inc.
    Inventors: H. Ralph Snodgrass, Joseph Cioffi, Thomas Joel Zupancic, Alan Wayne Shafer
  • Isolated nucleic acid encoding Hu-B1.219, a novel human hematopoietin
    Patent number: 5763211
    Abstract: The present invention relates to a novel member of the hematopoietin receptor family; herein referred to as Hu-B1.219. In particular, the invention relates to nucleotide sequences and expression vectors encoding Hu-B1.219 gene product Genetically engineered host cells that express the Hu-B1.219 coding sequence may be used to evaluate and screen for ligands or drugs involved in Hu-B1.219 interaction and regulation. Since Hu-B1.219 expression has been detected in certain human fetal tissues and cancer cells, molecular probes designed from its nucleotide sequence may be useful for prenatal testing and cancer diagnosis.
    Type: Grant
    Filed: December 14, 1994
    Date of Patent: June 9, 1998
    Assignee: Progenitor, Inc.
    Inventors: H. Ralph Snodgrass, Joseph Cioffi, Thomas Joel Zupancic, Alan Wayne Shafer
  • HU-B1.219, a novel human hematopoietin receptor
    Patent number: 5643748
    Abstract: The present invention relates to a novel member of the hematopoietin receptor family, herein referred to as Hu-B1.219. In particular, the invention relates to nucleotide sequences and expression vectors encoding Hu-B1.219 gene product. Genetically engineered host cells that express the Hu-B1.219 coding sequence may be used to evaluate and screen for ligands or drugs involved in Hu-B1.219 interaction and regulation. Since Hu-B1.219 expression has been detected in certain human fetal tissues and cancer cells, molecular probes designed from its nucleotide sequence may be useful for prenatal testing and cancer diagnosis.
    Type: Grant
    Filed: September 14, 1994
    Date of Patent: July 1, 1997
    Assignee: Progenitor, Inc.
    Inventors: H. Ralph Snodgrass, Joseph Cioffi, Thomas Joel Zupancic, Alan Wayne Shafer